The cap-snatching endonuclease of influenza virus polymerase resides in the PA subunit A Dias, D Bouvier, T Crépin, AA McCarthy, DJ Hart, F Baudin, S Cusack, ... Nature 458 (7240), 914-918, 2009 | 1021 | 2009 |
The structural basis for cap binding by influenza virus polymerase subunit PB2 D Guilligay, F Tarendeau, P Resa-Infante, R Coloma, T Crepin, P Sehr, ... Nature structural & molecular biology 15 (5), 500-506, 2008 | 634 | 2008 |
Cooperative binding of two acetylation marks on a histone tail by a single bromodomain J Moriniere, S Rousseaux, U Steuerwald, M Soler-López, S Curtet, ... Nature 461 (7264), 664-668, 2009 | 528 | 2009 |
Structural insight into cap-snatching and RNA synthesis by influenza polymerase S Reich, D Guilligay, A Pflug, H Malet, I Berger, T Crépin, D Hart, ... Nature 516 (7531), 361-366, 2014 | 483 | 2014 |
Structure and nuclear import function of the C-terminal domain of influenza virus polymerase PB2 subunit F Tarendeau, J Boudet, D Guilligay, PJ Mas, CM Bougault, S Boulo, ... Nature structural & molecular biology 14 (3), 229-233, 2007 | 412 | 2007 |
Influenza A virus polymerase: structural insights into replication and host adaptation mechanisms S Boivin, S Cusack, RWH Ruigrok, DJ Hart Journal of Biological Chemistry 285 (37), 28411-28417, 2010 | 300 | 2010 |
Host determinant residue lysine 627 lies on the surface of a discrete, folded domain of influenza virus polymerase PB2 subunit F Tarendeau, T Crepin, D Guilligay, RWH Ruigrok, S Cusack, DJ Hart PLoS pathogens 4 (8), e1000136, 2008 | 223 | 2008 |
Influenza polymerase can adopt an alternative configuration involving a radical repacking of PB2 domains E Thierry, D Guilligay, J Kosinski, T Bock, S Gaudon, A Round, A Pflug, ... Molecular cell 61 (1), 125-137, 2016 | 148 | 2016 |
Towards an atomic resolution understanding of the influenza virus replication machinery RWH Ruigrok, T Crépin, DJ Hart, S Cusack Current opinion in structural biology 20 (1), 104-113, 2010 | 140 | 2010 |
Structure and inhibition of herpesvirus DNA packaging terminase nuclease domain M Nadal, PJ Mas, AG Blanco, C Arnan, M Solà, DJ Hart, M Coll Proceedings of the National Academy of Sciences 107 (37), 16078-16083, 2010 | 139 | 2010 |
Structural Basis for the Oligomerization of the MADS Domain Transcription Factor SEPALLATA3 in Arabidopsis S Puranik, S Acajjaoui, S Conn, L Costa, V Conn, A Vial, R Marcellin, ... The Plant Cell 26 (9), 3603-3615, 2014 | 118 | 2014 |
Molecular determinants for nuclear import of influenza A PB2 by importin α isoforms 3 and 7 RA Pumroy, S Ke, DJ Hart, U Zachariae, G Cingolani Structure 23 (2), 374-384, 2015 | 114 | 2015 |
Functional protein microarrays for parallel characterisation of p53 mutants JM Boutell, DJ Hart, BLJ Godber, RZ Kozlowski, JM Blackburn Proteomics 4 (7), 1950-1958, 2004 | 99 | 2004 |
The salt dependence of DNA recognition by N-κB p50: A detailed kinetic analysis of the effects on affinity and specificity DJ Hart, RE Speight, JM Blackburn, MA Cooper, JD Sutherland Nucleic acids research 27 (4), 1063-1069, 1999 | 88 | 1999 |
Implementation of semi-automated cloning and prokaryotic expression screening: the impact of SPINE PM Alzari, H Berglund, NS Berrow, E Blagova, D Busso, C Cambillau, ... Acta Crystallographica Section D: Biological Crystallography 62 (10), 1103-1113, 2006 | 86 | 2006 |
Interaction of the influenza A virus polymerase PB2 C-terminal region with importin α isoforms provides insights into host adaptation and polymerase assembly S Boivin, DJ Hart Journal of Biological Chemistry 286 (12), 10439-10448, 2011 | 81 | 2011 |
Development of a Peptide that Selectively Activates Protein Phosphatase‐1 in Living Cells J Chatterjee, M Beullens, R Sukackaite, J Qian, B Lesage, DJ Hart, ... Angewandte Chemie International Edition 51 (40), 10054-10059, 2012 | 80 | 2012 |
ESPRIT: an automated, library-based method for mapping and soluble expression of protein domains from challenging targets H Yumerefendi, F Tarendeau, PJ Mas, DJ Hart Journal of structural biology 172 (1), 66-74, 2010 | 74 | 2010 |
Combinatorial library approaches for improving soluble protein expression in Escherichia coli DJ Hart, F Tarendeau Acta Crystallographica Section D: Biological Crystallography 62 (1), 19-26, 2006 | 71 | 2006 |
Large-scale conformational dynamics control H5N1 influenza polymerase PB2 binding to importin α E Delaforge, S Milles, G Bouvignies, D Bouvier, S Boivin, N Salvi, ... Journal of the American Chemical Society 137 (48), 15122-15134, 2015 | 51 | 2015 |