Site-directed fragment-based screening for the discovery of protein–protein interaction stabilizers E Sijbesma, KK Hallenbeck, S Leysen, PJ de Vink, L Skóra, W Jahnke, ... Journal of the American Chemical Society 141 (8), 3524-3531, 2019 | 100 | 2019 |
A Binary Bivalent Supramolecular Assembly Platform Based on Cucurbit [8] uril and Dimeric Adapter Protein 14‐3‐3 PJ de Vink, JM Briels, T Schrader, LG Milroy, L Brunsveld, C Ottmann Angewandte Chemie 129 (31), 9126-9130, 2017 | 90 | 2017 |
A thermodynamic model for multivalency in 14-3-3 protein–protein interactions LM Stevers, PJ De Vink, C Ottmann, J Huskens, L Brunsveld Journal of the American Chemical Society 140 (43), 14498-14510, 2018 | 57 | 2018 |
Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions SA Andrei, P de Vink, E Sijbesma, L Han, L Brunsveld, N Kato, C Ottmann, ... Angewandte Chemie International Edition 57 (41), 13470-13474, 2018 | 49 | 2018 |
Cooperativity basis for small-molecule stabilization of protein–protein interactions PJ de Vink, SA Andrei, Y Higuchi, C Ottmann, LG Milroy, L Brunsveld Chemical Science 10 (10), 2869-2874, 2019 | 38 | 2019 |
Selectivity via cooperativity: preferential stabilization of the p65/14-3-3 interaction with semisynthetic natural products M Wolter, P De Vink, JF Neves, S Srdanović, Y Higuchi, N Kato, A Wilson, ... Journal of the American Chemical Society 142 (27), 11772-11783, 2020 | 37 | 2020 |
Supramolecular enhancement of a natural 14–3–3 protein ligand X Guillory, I Hadrovic, PJ de Vink, A Sowislok, L Brunsveld, T Schrader, ... Journal of the American Chemical Society 143 (34), 13495-13500, 2021 | 13 | 2021 |
Cooperativity as quantification and optimization paradigm for nuclear receptor modulators PJ de Vink, AA Koops, G D'Arrigo, G Cruciani, F Spyrakis, L Brunsveld Chemical Science 13 (9), 2744-2752, 2022 | 11 | 2022 |
Selectivity via cooperativity: preferential stabilization of the p65 M Wolter, P de Vink, JF Neves, S Srdanovic, Y Higuchi, N Kato, A Wilson, ... | 9 | 2020 |
Andrei SA Higuchi Y. Ottmann C. Milroy L PJ De Vink G. Brunsveld L. Chem. Sci 10, 2869-2874, 2019 | 8 | 2019 |
Light-driven release of cucurbit [8] uril from a bivalent cage PJ de Vink, T van der Hek, L Brunsveld Chemical Science 12 (19), 6726-6731, 2021 | 6 | 2021 |
Straightforward model construction and analysis of multicomponent biomolecular systems in equilibrium NHJ Geertjens, PJ de Vink, T Wezeman, AJ Markvoort, L Brunsveld RSC Chemical Biology 4 (4), 252-260, 2023 | 4 | 2023 |
A general framework for straightforward model construction of multi-component thermodynamic equilibrium systems NHJ Geertjens, PJ de Vink, T Wezeman, AJ Markvoort, L Brunsveld bioRxiv, 2021.11. 18.469126, 2021 | 3 | 2021 |
Molecular Recognition of Proteins by Cucurbiturils PJ de Vink, L Brunsveld | 1 | 2019 |
Early identification of cooperative fragments for protein-protein interaction stabilization PJ de Vink, PJ Cossar, BA Somsen, C Ottmann, L Brunsveld bioRxiv, 2022.02. 23.481635, 2022 | | 2022 |
Protein Modulation by Cucurbiturils T Wezeman, PJD Vink, L Brunsveld | | 2020 |
A FRAGMENT-BASED SCREENING PARADIGM FOR THE DISCOVERY OF PROTEIN-PROTEIN INTERACTION STABILIZERS E SIJBESMA, S LEYSEN, P DE VINK, JMC ADRIAANS, J PETRICK, ... INFORMATION TO ALL USERS The quality of this reproduction is dependent upon …, 2018 | | 2018 |
Full wwPDB X-ray Structure Validation Report i○ PJ de Vink, C Ottmann | | |