Leilei Zhong
Leilei Zhong
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Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment
L Zhong, L Yao, RJ Tower, Y Wei, Z Miao, J Park, R Shrestha, L Wang, ...
Elife 9, e54695, 2020
The regulatory role of signaling crosstalk in hypertrophy of MSCs and human articular chondrocytes
L Zhong, X Huang, M Karperien, JN Post
International journal of molecular sciences 16 (8), 19225-19247, 2015
Bone marrow adipogenic lineage precursors promote osteoclastogenesis in bone remodeling and pathologic bone loss
W Yu, L Zhong, L Yao, Y Wei, T Gui, Z Li, H Kim, N Holdreith, X Jiang, ...
The Journal of clinical investigation 131 (2), 2021
Correlation between gene expression and osteoarthritis progression in human
L Zhong, X Huang, M Karperien, JN Post
International journal of molecular sciences 17 (7), 1126, 2016
Targeting cartilage EGFR pathway for osteoarthritis treatment
Y Wei, L Luo, T Gui, F Yu, L Yan, L Yao, L Zhong, W Yu, B Han, JM Patel, ...
Science translational medicine 13 (576), eabb3946, 2021
T cell factor 4 is a pro-catabolic and apoptotic factor in human articular chondrocytes by potentiating nuclear factor κB signaling
B Ma, L Zhong, CA van Blitterswijk, JN Post, M Karperien
Journal of Biological Chemistry 288 (24), 17552-17558, 2013
Superoxide dismutase-loaded porous polymersomes as highly efficient antioxidant nanoparticles targeting synovium for osteoarthritis therapy
T Gui, L Luo, B Chhay, L Zhong, Y Wei, L Yao, W Yu, J Li, CL Nelson, ...
Biomaterials 283, 121437, 2022
The effects of the WNT-signaling modulators BIO and PKF118-310 on the chondrogenic differentiation of human mesenchymal stem cells
X Huang, L Zhong, J Hendriks, JN Post, M Karperien
International journal of molecular sciences 19 (2), 561, 2018
Endogenous DKK1 and FRZB regulate chondrogenesis and hypertrophy in three-dimensional cultures of human chondrocytes and human mesenchymal stem cells
L Zhong, X Huang, ED Rodrigues, JCH Leijten, T Verrips, M El Khattabi, ...
Stem cells and development 25 (23), 1808-1817, 2016
Nitric oxide mediates crosstalk between interleukin 1β and WNT signaling in primary human chondrocytes by reducing DKK1 and FRZB expression
L Zhong, S Schivo, X Huang, J Leijten, M Karperien, JN Post
International journal of molecular sciences 18 (11), 2491, 2017
Proteasome inhibitor bortezomib is a novel therapeutic agent for focal radiation-induced osteoporosis
A Chandra, L Wang, T Young, L Zhong, WJ Tseng, MA Levine, K Cengel, ...
The FASEB Journal 32 (1), 52, 2018
Periarticular mesenchymal progenitors initiate and contribute to secondary ossification center formation during mouse long bone development
W Tong, RJ Tower, C Chen, L Wang, L Zhong, Y Wei, H Sun, G Cao, H Jia, ...
Stem Cells 37 (5), 677-689, 2019
Promoted chondrogenesis of cocultured chondrocytes and mesenchymal stem cells under hypoxia using in-situ forming degradable hydrogel scaffolds
X Huang, Y Hou, LL Zhong, D Huang, H Qian, M Karperien, W Chen
Biomacromolecules 19 (1), 94-102, 2018
Co-treatment of TGF-β3 and BMP7 is superior in stimulating chondrocyte redifferentiation in both hypoxia and normoxia compared to single treatments
X Huang, L Zhong, JN Post, M Karperien
Scientific reports 8 (1), 10251, 2018
Gli1 Defines a Subset of Fibro‐adipogenic Progenitors that Promote Skeletal Muscle Regeneration With Less Fat Accumulation
L Yao, ED Tichy, L Zhong, S Mohanty, L Wang, E Ai, S Yang, F Mourkioti, ...
Journal of Bone and Mineral Research 36 (6), 1159-1173, 2020
Marrow adipogenic lineage precursor: A new cellular component of marrow adipose tissue
L Zhong, L Yao, P Seale, L Qin
Best Practice & Research Clinical Endocrinology & Metabolism 35 (4), 101518, 2021
EGFR signaling is required for maintaining adult cartilage homeostasis and attenuating osteoarthritis progression
Y Wei, X Ma, H Sun, T Gui, J Li, L Yao, L Zhong, W Yu, B Han, CL Nelson, ...
Journal of Bone and Mineral Research 37 (5), 1012-1023, 2020
Dickkopf-related protein 1 and gremlin 1 show different response than frizzled-related protein in human synovial fluid following knee injury and in patients with osteoarthritis
X Huang, JN Post, L Zhong, J Leijten, S Larsson, M Karperien, A Struglics
Osteoarthritis and cartilage 26 (6), 834-843, 2018
Csf1 from marrow adipogenic precursors is required for osteoclast formation and hematopoiesis in bone
L Zhong, J Lu, J Fang, L Yao, W Yu, T Gui, M Duffy, N Holdreith, ...
Elife 12, e82112, 2023
The expressions of Dickkopf-related protein 1 and frizzled-related protein are negatively correlated to local inflammation and osteoarthritis severity
X Huang, L Zhong, E van Helvoort, F Lafeber, S Mastbergen, J Hendriks, ...
Cartilage 12 (4), 496-504, 2021
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