Lawrence Kazak
Lawrence Kazak
Assistant Professor, Goodman Cancer Institute and Dept of Biochemistry, McGill University
Verified email at - Homepage
Cited by
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A creatine-driven substrate cycle enhances energy expenditure and thermogenesis in beige fat
L Kazak, ET Chouchani, MP Jedrychowski, BK Erickson, K Shinoda, ...
Cell 163 (3), 643-655, 2015
Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia
S Kir, JP White, S Kleiner, L Kazak, P Cohen, VE Baracos, ...
Nature 513 (7516), 100-104, 2014
New advances in adaptive thermogenesis: UCP1 and beyond
ET Chouchani, L Kazak, BM Spiegelman
Cell metabolism 29 (1), 27-37, 2019
Minimizing the damage: repair pathways keep mitochondrial DNA intact
L Kazak, A Reyes, IJ Holt
Nature reviews Molecular cell biology 13 (10), 659-671, 2012
Accumulation of succinate controls activation of adipose tissue thermogenesis
EL Mills, KA Pierce, MP Jedrychowski, R Garrity, S Winther, S Vidoni, ...
Nature 560 (7716), 102-106, 2018
Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1
ET Chouchani, L Kazak, MP Jedrychowski, GZ Lu, BK Erickson, J Szpyt, ...
Nature 532 (7597), 112-116, 2016
mTOR as a central regulator of lifespan and aging
D Papadopoli, K Boulay, L Kazak, M Pollak, FA Mallette, I Topisirovic, ...
F1000Research 8, 2019
Fat cells directly sense temperature to activate thermogenesis
L Ye, J Wu, P Cohen, L Kazak, MJ Khandekar, MP Jedrychowski, X Zeng, ...
Proceedings of the National Academy of Sciences 110 (30), 12480-12485, 2013
IRF4 is a key thermogenic transcriptional partner of PGC-1α
X Kong, A Banks, T Liu, L Kazak, RR Rao, P Cohen, X Wang, S Yu, JC Lo, ...
Cell 158 (1), 69-83, 2014
Genetic depletion of adipocyte creatine metabolism inhibits diet-induced thermogenesis and drives obesity
L Kazak, ET Chouchani, GZ Lu, MP Jedrychowski, CJ Bare, AI Mina, ...
Cell metabolism 26 (4), 660-671. e3, 2017
Mitochondrial patch clamp of beige adipocytes reveals UCP1-positive and UCP1-negative cells both exhibiting futile creatine cycling
AM Bertholet, L Kazak, ET Chouchani, MG Bogaczyńska, I Paranjpe, ...
Cell metabolism 25 (4), 811-822. e4, 2017
H+ transport is an integral function of the mitochondrial ADP/ATP carrier
AM Bertholet, ET Chouchani, L Kazak, A Angelin, A Fedorenko, JZ Long, ...
Nature 571 (7766), 515-520, 2019
Brown adipose tissue controls skeletal muscle function via the secretion of myostatin
X Kong, T Yao, P Zhou, L Kazak, D Tenen, A Lyubetskaya, BA Dawes, ...
Cell metabolism 28 (4), 631-643. e3, 2018
UCP1 deficiency causes brown fat respiratory chain depletion and sensitizes mitochondria to calcium overload-induced dysfunction
L Kazak, ET Chouchani, IG Stavrovskaya, GZ Lu, MP Jedrychowski, ...
Proceedings of the National Academy of Sciences 114 (30), 7981-7986, 2017
IRF3 promotes adipose inflammation and insulin resistance and represses browning
M Kumari, X Wang, L Lantier, A Lyubetskaya, J Eguchi, S Kang, D Tenen, ...
The Journal of clinical investigation 126 (8), 2839-2854, 2016
Mitochondrial DNA replication proceeds via a ‘bootlace’mechanism involving the incorporation of processed transcripts
A Reyes, L Kazak, SR Wood, T Yasukawa, HT Jacobs, IJ Holt
Nucleic acids research 41 (11), 5837-5850, 2013
Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity
L Kazak, JF Rahbani, B Samborska, GZ Lu, MP Jedrychowski, M Lajoie, ...
Nature metabolism 1 (3), 360-370, 2019
Creatine metabolism: energy homeostasis, immunity and cancer biology
L Kazak, P Cohen
Nature Reviews Endocrinology 16 (8), 421-436, 2020
UCP1-independent thermogenesis
A Roesler, L Kazak
Biochemical Journal 477 (3), 709-725, 2020
Actin and myosin contribute to mammalian mitochondrial DNA maintenance
A Reyes, J He, CC Mao, LJ Bailey, M Di Re, H Sembongi, L Kazak, ...
Nucleic acids research 39 (12), 5098-5108, 2011
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