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sandeep k ravala
sandeep k ravala
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Cited by
Year
Cryo–electron microscopy structure and analysis of the P-Rex1–Gβγ signaling scaffold
JN Cash, S Urata, S Li, SK Ravala, LV Avramova, MD Shost, JS Gutkind, ...
Science advances 5 (10), eaax8855, 2019
322019
Evidence that phosphorylation of threonine in the GT motif triggers activation of PknA, a eukaryotic‐type serine/threonine kinase from Mycobacterium tuberculosis
SK Ravala, S Singh, GS Yadav, S Kumar, S Karthikeyan, PK Chakraborti
The FEBS journal 282 (8), 1419-1431, 2015
222015
The first DEP domain of the RhoGEF P-Rex1 autoinhibits activity and contributes to membrane binding
SK Ravala, JB Hopkins, CB Plescia, SR Allgood, MA Kane, JN Cash, ...
Journal of Biological Chemistry 295 (36), 12635-12647, 2020
122020
Phosphorylation modulates catalytic activity of mycobacterial sirtuins
GS Yadav, SK Ravala, N Malhotra, PK Chakraborti
Frontiers in microbiology 7, 191359, 2016
82016
Structural/functional studies of Trio provide insights into its configuration and show that conserved linker elements enhance its activity for Rac1
SJ Bandekar, CL Chen, SK Ravala, JN Cash, LV Avramova, MV Zhalnina, ...
Journal of Biological Chemistry 298 (8), 2022
42022
Molecular basis for Gβγ-mediated activation of phosphoinositide 3-kinase γ
CL Chen, R Syahirah, SK Ravala, YC Yen, T Klose, Q Deng, JJG Tesmer
Nature Structural & Molecular Biology, 1-10, 2024
12024
Structural dynamics in RhoGEF signaling investigated using model cell membranes
S Ravala, S Adame-Garcia, S Li, CL Chen, MA Cianfrocco, JS Gutkind, ...
Biophysical Journal 123 (3), 152a, 2024
2024
Mechanistic and Structural Studies of the Membrane-associated RhoGEF P-Rex and its Modes of Regulation
L Anderson, S Ravala, S Li, J Tesmer, J Cash
PROTEIN SCIENCE 32 (12), 2023
2023
Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4
SK Ravala, SR Adame-Garcia, S Li, CL Chen, MA Cianfrocco, JS Gutkind, ...
bioRxiv, 2023
2023
Structural and Mechanistic Basis for Gbetagamma-mediated Activation of Phosphoinositide 3-kinase-gamma
CL Chen, S Ravala, YC Yen, T Klose, R Syahirah, JJG Tesmer, Q Deng
Journal of Pharmacology and Experimental Therapeutics 385 (S3), 2023
2023
New insights into regulation of P‐Rex1 autoinhibition
SK Ravala, S Li, CL Chen, MA Cianfrocco, JN Cash, JJG Tesmer
The FASEB Journal 36, 2022
2022
Single Particle Cryo‐EM Reconstruction of the P‐Rex1–Gβγ Complex Reveals Mechanisms Underlying Cellular Migration Mediated by GPCRs
J Cash, S Urata, S Li, S Ravala, M Cianfrocco, J Tesmer
The FASEB Journal 33 (S1), 668.2-668.2, 2019
2019
Structural Snapshots of a Dynamic Process in the Regulation of P-Rex, a Metastatic Factor
JN Cash, S Ravala, JJG Tesmer, MA Cianfrocco
Microscopy and Microanalysis 24 (S1), 1218-1219, 2018
2018
Structural Characterization of the DEP Domains of P-Rex1
SR Allgood, JJG Tesmer, SK Ravala
2018
Evidence for the interplay between post‐translational modifications in regulating mycobacterial sirtuin activity
GS Yadav, SK Ravala, N Malhotra, PK Chakraborti
The FASEB Journal 30, 1131.1-1131.1, 2016
2016
Deciphering crucial threonines towards functionality of an essential eukaryotic‐type Ser/Thr kinase from M. tuberculosis (802.1)
S Ravala, G Yadav, P Chakraborti
The FASEB Journal 28, 802.1, 2014
2014
Studies on a mycobacterial eukaryotic-type serine/theronine kinase and its interacting partners
SK Ravala
CSIR-IMTECH, Chandigarh/Jawaharlal Nehru University, New Delhi, 2013
2013
Eukaryotic-type Serine/Threonine kinase mediated phosphorylation at Threonine-169 perturbs mycobacterial guanylate kinase activity
GS Yadav, SK Ravala, S Kachhap, M Thakur, A Roy, B Singh, ...
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