| Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and … JM Axten, JR Medina, Y Feng, A Shu, SP Romeril, SW Grant, WHH Li, ... Journal of medicinal chemistry 55 (16), 7193-7207, 2012 | 658 | 2012 |
| Oral treatment targeting the unfolded protein response prevents neurodegeneration and clinical disease in prion-infected mice JA Moreno, M Halliday, C Molloy, H Radford, N Verity, JM Axten, CA Ortori, ... Science translational medicine 5 (206), 206ra138-206ra138, 2013 | 634 | 2013 |
| Characterization of a novel PERK kinase inhibitor with antitumor and antiangiogenic activity C Atkins, Q Liu, E Minthorn, SY Zhang, DJ Figueroa, K Moss, TB Stanley, ... Cancer research 73 (6), 1993-2002, 2013 | 477 | 2013 |
| Discovery of GSK2656157: an optimized PERK inhibitor selected for preclinical development JM Axten, SP Romeril, A Shu, J Ralph, JR Medina, Y Feng, WHH Li, ... ACS medicinal chemistry letters 4 (10), 964-968, 2013 | 225 | 2013 |
| Pharmacological targeting of the unfolded protein response for disease intervention C Hetz, JM Axten, JB Patterson Nature chemical biology 15 (8), 764-775, 2019 | 217 | 2019 |
| The first total syntheses of ircinol A, ircinal A, and manzamines A and D JD Winkler, JM Axten Journal of the American Chemical Society 120 (25), 6425, 1998 | 192 | 1998 |
| Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1 A Najafov, EM Sommer, JM Axten, MP DeYoung, DR Alessi Biochemical Journal 433 (2), 357-369, 2011 | 156 | 2011 |
| Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease G Mercado, V Castillo, P Soto, N López, JM Axten, SP Sardi, ... Neurobiology of disease 112, 136-148, 2018 | 145 | 2018 |
| Enantioselective synthesis of D-threo-methylphenidate JM Axten, R Ivy, L Krim, JD Winkler Journal of the American Chemical Society 121 (27), 6511-6512, 1999 | 114 | 1999 |
| A Stereoselective Synthesis of dl-threo-Methylphenidate: Preparation and Biological Evaluation of Novel Analogues JM Axten, L Krim, HF Kung, JD Winkler The Journal of Organic Chemistry 63 (26), 9628-9629, 1998 | 100 | 1998 |
| Structure-based design of potent and selective 3-phosphoinositide-dependent kinase-1 (PDK1) inhibitors JR Medina, CJ Becker, CW Blackledge, C Duquenne, Y Feng, SW Grant, ... Journal of medicinal chemistry 54 (6), 1871-1895, 2011 | 71 | 2011 |
| Stereoselective synthesis of the tetracyclic core of manzamine via the vinylogous amide photocycloaddition cascade JD Winkler, J Axten, AH Hammach, YS Kwak, U Lengweiler, MJ Lucero, ... Tetrahedron 54 (25), 7045-7056, 1998 | 56 | 1998 |
| Enantopselective synthesis of methyl phenidate JD Winklter, JM Axten, L Krim US Patent 6,025,502, 2000 | 54 | 2000 |
| Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases TJ Miles, JM Axten, C Barfoot, G Brooks, P Brown, D Chen, S Dabbs, ... Bioorganic & medicinal chemistry letters 21 (24), 7489-7495, 2011 | 53 | 2011 |
| Two highly efficient syntheses of scalemic azocines JD Winkler, JE Stelmach, J Axten Tetrahedron letters 37 (25), 4317-4318, 1996 | 47 | 1996 |
| Compounds JM Axten, RA Daines, DT Davies, TF Gallagher, GE Jones, WH Miller, ... US Patent 7,498,326, 2009 | 43* | 2009 |
| PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome V Grande, F Ornaghi, L Comerio, E Restelli, A Masone, A Corbelli, ... Human molecular genetics 27 (14), 2477-2489, 2018 | 39 | 2018 |
| Chemical compounds JM Axten, CW Blackledge, GP Brady, Y Feng, SW Grant, JR Medina, ... US Patent 8,697,685, 2014 | 36 | 2014 |
| Aminoindazole PDK1 inhibitors: a case study in fragment-based drug discovery JR Medina, CW Blackledge, DA Heerding, N Campobasso, P Ward, ... ACS medicinal chemistry letters 1 (8), 439-442, 2010 | 36 | 2010 |
| Protein kinase R (PKR)–like endoplasmic reticulum kinase (PERK) inhibitors: a patent review (2010-2015) JM Axten Expert opinion on therapeutic patents 27 (1), 37-48, 2017 | 27 | 2017 |
