| Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease CC Bell, DFG Hendriks, SML Moro, E Ellis, J Walsh, A Renblom, ... Scientific reports 6 (1), 1-13, 2016 | 660 | 2016 |
| The size of endothelial fenestrae in human liver sinusoids: implications for hepatocyte-directed gene transfer E Wisse, F Jacobs, B Topal, P Frederik, B De Geest Gene therapy 15 (17), 1193-1199, 2008 | 302 | 2008 |
| Comparison of hepatic 2D sandwich cultures and 3D spheroids for long-term toxicity applications: a multicenter study CC Bell, ACA Dankers, VM Lauschke, R Sison-Young, R Jenkins, ... Toxicological Sciences 162 (2), 655-666, 2018 | 274 | 2018 |
| The role of liver sinusoidal cells in hepatocyte-directed gene transfer F Jacobs, E Wisse, B De Geest The American journal of pathology 176 (1), 14-21, 2010 | 147 | 2010 |
| Species differences in transgene DNA uptake in hepatocytes after adenoviral transfer correlate with the size of endothelial fenestrae J Snoeys, J Lievens, E Wisse, F Jacobs, H Duimel, D Collen, P Frederik, ... Gene therapy 14 (7), 604-612, 2007 | 103 | 2007 |
| Human apoA-I transfer attenuates transplant arteriosclerosis via enhanced incorporation of bone marrow–derived endothelial progenitor cells Y Feng, F Jacobs, E Van Craeyveld, C Brunaud, J Snoeys, M Tjwa, ... Arteriosclerosis, thrombosis, and vascular biology 28 (2), 278-283, 2008 | 102 | 2008 |
| Human Apo AI Transfer attenuates Transplant Arteriosclerosis via Enhanced Incorporation of Bone Marrow-derived Endothelial Progenitor Cells Y Feng, F Jacobs, M Tjwa, J Snoeys, S Van Linthout, B De Geest Circulation 116 (suppl_16), II_263-II_264, 2007 | 102 | 2007 |
| Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines R Boon, M Kumar, T Tricot, I Elia, L Ordovas, F Jacobs, J One, J De Smedt, ... Nature communications 11 (1), 1-16, 2020 | 101 | 2020 |
| Vascular-protective effects of high-density lipoprotein include the downregulation of the angiotensin II type 1 receptor S Van Linthout, F Spillmann, M Lorenz, M Meloni, F Jacobs, M Egorova, ... Hypertension 53 (4), 682-687, 2009 | 98 | 2009 |
| Critical role of scavenger receptor-BI–expressing bone marrow–derived endothelial progenitor cells in the attenuation of allograft vasculopathy after human apo AI transfer Y Feng, M van Eck, E Van Craeyveld, F Jacobs, V Carlier, S Van Linthout, ... Blood, The Journal of the American Society of Hematology 113 (3), 755-764, 2009 | 96 | 2009 |
| Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial … SH Kassim, H Li, P Bell, S Somanathan, W Lagor, F Jacobs, J Billheimer, ... Human gene therapy 24 (1), 19-26, 2013 | 89 | 2013 |
| Regression and stabilization of advanced murine atherosclerotic lesions: a comparison of LDL lowering and HDL raising gene transfer strategies E Van Craeyveld, SC Gordts, E Nefyodova, F Jacobs, B De Geest Journal of molecular medicine 89 (6), 555-567, 2011 | 74 | 2011 |
| 4 REGRESSION AND STABILIZATION OF ADVANCED MURINE ATHEROSCLEROTIC LESIONS: A COMPARISON OF LDL LOWERING AND HDL RAISING GENE TRANSFER STRATEGIES E Van Craeyveld, SC Gordts, E Nefyodova, F Jacobs, B De Geest Atherosclerosis (Supplements)(Component) 1 (12), 1, 2011 | 74 | 2011 |
| Direct comparison of hepatocyte-specific expression cassettes following adenoviral and nonviral hydrodynamic gene transfer F Jacobs, J Snoeys, Y Feng, E Van Craeyveld, J Lievens, D Armentano, ... Gene therapy 15 (8), 594-603, 2008 | 68 | 2008 |
| Permanent ligation of the left anterior descending coronary artery in mice: a model of post-myocardial infarction remodelling and heart failure I Muthuramu, M Lox, F Jacobs, B De Geest Journal of visualized experiments: JoVE, 2014 | 62 | 2014 |
| Circulating apoptotic endothelial cells and apoptotic endothelial microparticles independently predict the presence of cardiac allograft vasculopathy N Singh, E Van Craeyveld, M Tjwa, A Ciarka, J Emmerechts, W Droogne, ... Journal of the American College of Cardiology 60 (4), 324-331, 2012 | 61 | 2012 |
| AAV vectors expressing LDLR gain-of-function variants demonstrate increased efficacy in mouse models of familial hypercholesterolemia S Somanathan, F Jacobs, Q Wang, AL Hanlon, JM Wilson, DJ Rader Circulation research 115 (6), 591-599, 2014 | 60 | 2014 |
| Hepatic differentiation of human induced pluripotent stem cells in a perfused three-dimensional multicompartment bioreactor N Freyer, F Knöspel, N Strahl, L Amini, P Schrade, S Bachmann, G Damm, ... BioResearch open access 5 (1), 235-248, 2016 | 59 | 2016 |
| The liver as a target organ for gene therapy: state of the art, challenges, and future perspectives F Jacobs, SC Gordts, I Muthuramu, B De Geest Pharmaceuticals 5 (12), 1372-1392, 2012 | 49 | 2012 |
| Beneficial effects of selective HDL-raising gene transfer on survival, cardiac remodelling and cardiac function after myocardial infarction in mice SC Gordts, I Muthuramu, E Nefyodova, F Jacobs, E Van Craeyveld, ... Gene therapy 20 (11), 1053-1061, 2013 | 46 | 2013 |
