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Yingleong Chan
Yingleong Chan
Department of Genetics, Harvard Medical School
Geverifieerd e-mailadres voor genetics.med.harvard.edu
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Biological interpretation of genome-wide association studies using predicted gene functions
TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ...
Nature communications 6 (1), 5890, 2015
8262015
Distribution and medical impact of loss-of-function variants in the Finnish founder population
ET Lim, P Würtz, AS Havulinna, P Palta, T Tukiainen, K Rehnström, ...
PLoS genetics 10 (7), e1004494, 2014
4432014
An enhanced CRISPR repressor for targeted mammalian gene regulation
NC Yeo, A Chavez, A Lance-Byrne, Y Chan, D Menn, D Milanova, ...
Nature methods 15 (8), 611-616, 2018
4162018
Rates, distribution and implications of postzygotic mosaic mutations in autism spectrum disorder
ET Lim, M Uddin, S De Rubeis, Y Chan, AS Kamumbu, X Zhang, ...
Nature neuroscience 20 (9), 1217-1224, 2017
2622017
Directional dominance on stature and cognition in diverse human populations
PK Joshi, T Esko, H Mattsson, N Eklund, I Gandin, T Nutile, AU Jackson, ...
Nature 523 (7561), 459-462, 2015
1812015
Engineering adeno-associated viral vectors to evade innate immune and inflammatory responses
YK Chan, SK Wang, CJ Chu, DA Copland, AJ Letizia, H Costa Verdera, ...
Science translational medicine 13 (580), eabd3438, 2021
1292021
High-throughput creation and functional profiling of DNA sequence variant libraries using CRISPR–Cas9 in yeast
X Guo, A Chavez, A Tung, Y Chan, C Kaas, Y Yin, R Cecchi, SL Garnier, ...
Nature biotechnology 36 (6), 540-546, 2018
872018
Synthesizing genome-wide association studies and expression microarray reveals novel genes that act in the human growth plate to modulate height
JC Lui, O Nilsson, Y Chan, CD Palmer, AC Andrade, JN Hirschhorn, ...
Human molecular genetics 21 (23), 5193-5201, 2012
792012
Genome-wide analysis of body proportion classifies height-associated variants by mechanism of action and implicates genes important for skeletal development
Y Chan, RM Salem, YHH Hsu, G McMahon, TH Pers, S Vedantam, T Esko, ...
The American Journal of Human Genetics 96 (5), 695-708, 2015
732015
Common variants show predicted polygenic effects on height in the tails of the distribution, except in extremely short individuals
Y Chan, OL Holmen, A Dauber, L Vatten, AS Havulinna, F Skorpen, ...
PLoS genetics 7 (12), e1002439, 2011
662011
An excess of risk-increasing low-frequency variants can be a signal of polygenic inheritance in complex diseases
Y Chan, ET Lim, N Sandholm, SR Wang, AJ McKnight, S Ripke, MJ Daly, ...
The American Journal of Human Genetics 94 (3), 437-452, 2014
472014
A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity
ET Lim, YP Liu, Y Chan, T Tiinamaija, AM Käräjämäki, E Madsen, ...
The American Journal of Human Genetics 95 (5), 509-520, 2014
362014
A novel test for recessive contributions to complex diseases implicates Bardet-Biedl syndrome gene BBS10 in idiopathic type 2 diabetes and obesity
ET Lim, YP Liu, Y Chan, T Tiinamaija, AM Käräjämäki, E Madsen, ...
The American Journal of Human Genetics 95 (5), 509-520, 2014
362014
Genetic Investigation of ANthropometric Traits (GIANT) Consortium Biological interpretation of genome-wide association studies using predicted gene functions
TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ...
Nat. Commun 6, 5890, 2015
222015
Biological interpretation of genome-wide association studies using predicted gene functions. Nat Commun. 2015; 6: 5890
TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ...
17
Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder
ET Lim, Y Chan, P Dawes, X Guo, S Erdin, DJC Tai, S Liu, JM Reichert, ...
Nature Communications 13 (1), 3243, 2022
122022
Enabling multiplexed testing of pooled donor cells through whole-genome sequencing
Y Chan, YK Chan, DB Goodman, X Guo, A Chavez, ET Lim, GM Church
Genome Medicine 10, 1-11, 2018
92018
Genetic Investigation of ATC, Boehnke M, Raychaudhuri S, Fehrmann RS, Hirschhorn JN, Franke L
TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, J Yang, JC Lui, ...
Biological interpretation of genome-wide association studies using predicted …, 2015
92015
An unbiased index to quantify participant’s phenotypic contribution to an open-access cohort
Y Chan, M Tung, AS Garruss, SW Zaranek, YK Chan, JE Lunshof, ...
Scientific Reports 7 (1), 46148, 2017
62017
Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids
ET Lim, Y Chan, MJ Burns, X Guo, S Erdin, DJC Tai, JM Reichert, ...
bioRxiv, 2020.11. 15.375386, 2020
52020
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Artikelen 1–20