Amanda Swart
Amanda Swart
Professor of Biochemistry, Stellenbosch University
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11β-Hydroxydihydrotestosterone and 11-ketodihydrotestosterone, novel C19 steroids with androgenic activity: a putative role in castration resistant prostate cancer?
KH Storbeck, LM Bloem, D Africander, L Schloms, P Swart, AC Swart
Molecular and cellular endocrinology 377 (1-2), 135-146, 2013
Progesterone 16 alpha-hydroxylase activity is catalyzed by human cytochrome P450 17 alpha-hydroxylase
P Swart, AC Swart, MR Waterman, RW Estabrook, JI Mason
The Journal of Clinical Endocrinology & Metabolism 77 (1), 98-102, 1993
The influence of Aspalathus linearis (Rooibos) and dihydrochalcones on adrenal steroidogenesis: quantification of steroid intermediates and end products in H295R cells
L Schloms, KH Storbeck, P Swart, WCA Gelderblom, AC Swart
The Journal of steroid biochemistry and molecular biology 128 (3-5), 128-138, 2012
11β-hydroxyandrostenedione, the product of androstenedione metabolism in the adrenal, is metabolized in LNCaP cells by 5α-reductase yielding 11β-hydroxy-5α-androstanedione
AC Swart, L Schloms, KH Storbeck, LM Bloem, T du Toit, JL Quanson, ...
The Journal of steroid biochemistry and molecular biology 138, 132-142, 2013
11β-Hydroxyandrostenedione: downstream metabolism by 11βHSD, 17βHSD and SRD5A produces novel substrates in familiar pathways
AC Swart, KH Storbeck
Molecular and cellular endocrinology 408, 114-123, 2015
Profiling adrenal 11β-hydroxyandrostenedione metabolites in prostate cancer cells, tissue and plasma: UPC2-MS/MS quantification of 11β-hydroxytestosterone, 11keto-testosterone …
T du Toit, LM Bloem, JL Quanson, R Ehlers, AM Serafin, AC Swart
The Journal of steroid biochemistry and molecular biology 166, 54-67, 2017
Discovery of Compound A–a selective activator of the glucocorticoid receptor with anti-inflammatory and anti-cancer activity
E Lesovaya, A Yemelyanov, AC Swart, P Swart, G Haegeman, ...
Oncotarget 6 (31), 30730, 2015
11β-hydroxyandrostenedione returns to the steroid arena: biosynthesis, metabolism and function
LM Bloem, KH Storbeck, L Schloms, AC Swart
Molecules 18 (11), 13228-13244, 2013
Advances in the analytical methodologies: Profiling steroids in familiar pathways-challenging dogmas
LM Bloem, KH Storbeck, P Swart, T du Toit, L Schloms, AC Swart
The Journal of steroid biochemistry and molecular biology 153, 80-92, 2015
A single amino acid residue, Ala 105, confers 16α-hydroxylase activity to human cytochrome P450 17α-hydroxylase/17, 20 lyase
AC Swart, KH Storbeck, P Swart
The Journal of steroid biochemistry and molecular biology 119 (3-5), 112-120, 2010
Cytochrome b5: novel roles in steroidogenesis
KH Storbeck, AC Swart, P Goosen, P Swart
Molecular and cellular endocrinology 371 (1-2), 87-99, 2013
Functional expression and characterisation of human cytochrome P45017α in Pichia pastoris
NW Kolar, AC Swart, JI Mason, P Swart
Journal of biotechnology 129 (4), 635-644, 2007
The effect of Sutherlandia frutescens on steroidogenesis: confirming indigenous wisdom
D Prevoo, C Smith, P Swart, AC Swart
Endocrine research 30 (4), 745-751, 2004
The influence of Sutherlandia frutescens on adrenal steroidogenic cytochrome P450 enzymes
D Prevoo, P Swart, AC Swart
Journal of ethnopharmacology 118 (1), 118-126, 2008
Biological activities of the shrub Salsola tuberculatiformis Botsch.: Contraceptive or stress alleviator?
P Swart, AC Swart, A Louw, KJ van der Merwe
Bioessays 25 (6), 612-619, 2003
Rooibos flavonoids inhibit the activity of key adrenal steroidogenic enzymes, modulating steroid hormone levels in H295R cells
L Schloms, AC Swart
Molecules 19 (3), 3681-3695, 2014
Aspalathus linearis (Rooibos)–a functional food targeting cardiovascular disease
C Smith, A Swart
Food & function 9 (10), 5041-5058, 2018
The development of an ultra performance liquid chromatography-coupled atmospheric pressure chemical ionization mass spectrometry assay for seven adrenal steroids
KH Storbeck, NW Kolar, M Stander, AC Swart, D Prevoo, P Swart
Analytical biochemistry 372 (1), 11-20, 2008
Cytochrome P450 side-chain cleavage: insights gained from homology modeling
KH Storbeck, P Swart, AC Swart
Molecular and cellular endocrinology 265, 65-70, 2007
Inhibition of cytochrome P-45011β by some naturally occurring acetophenones and plant extracts from the shrub Salsola tuberculatiformis
P Swart, KJ van der Merwe, AC Swart, PC Todres, JHS Hofmeyr
Planta medica 59 (02), 139-143, 1993
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