Brief treatment with the glucocorticoid receptor antagonist mifepristone normalises the corticosterone‐induced reduction of adult hippocampal neurogenesis JL Mayer, L Klumpers, S Maslam, ER De Kloet, M Joels, PJ Lucassen Journal of neuroendocrinology 18 (8), 629-631, 2006 | 207 | 2006 |
Manipulating brain connectivity with δ9-tetrahydrocannabinol: a pharmacological resting state FMRI study LE Klumpers, DM Cole, N Khalili-Mahani, RP Soeter, ET Te Beek, ... Neuroimage 63 (3), 1701-1711, 2012 | 82 | 2012 |
Novel Δ9‐tetrahydrocannabinol formulation Namisol® has beneficial pharmacokinetics and promising pharmacodynamic effects LE Klumpers, TL Beumer, JGC van Hasselt, A Lipplaa, LB Karger, ... British journal of clinical pharmacology 74 (1), 42-53, 2012 | 78 | 2012 |
Peripheral selectivity of the novel cannabinoid receptor antagonist TM 38837 in healthy subjects LE Klumpers, M Fridberg, ML de Kam, PB Little, NO Jensen, HD Kleinloog, ... British journal of clinical pharmacology 76 (6), 846-857, 2013 | 65 | 2013 |
Population pharmacokinetic model of THC integrates oral, intravenous, and pulmonary dosing and characterizes short-and long-term pharmacokinetics JAAC Heuberger, Z Guan, OO Oyetayo, L Klumpers, PD Morrison, ... Clinical pharmacokinetics 54 (2), 209-219, 2015 | 43 | 2015 |
A brief background on cannabis: From plant to medical indications LE Klumpers, DL Thacker Journal of AOAC International 102 (2), 412-420, 2019 | 28 | 2019 |
Surinabant, a selective cannabinoid receptor type 1 antagonist, inhibits Δ9‐tetrahydrocannabinol‐induced central nervous system and heart rate effects in humans LE Klumpers, C Roy, G Ferron, S Turpault, F Poitiers, JL Pinquier, ... British journal of clinical pharmacology 76 (1), 65-77, 2013 | 24 | 2013 |
Subjective Effects of Ethanol, Morphine, Δ9-Tetrahydrocannabinol, and Ketamine Following a Pharmacological Challenge Are Related to Functional Brain Connectivity D Kleinloog, S Rombouts, R Zoethout, L Klumpers, M Niesters, ... Brain connectivity 5 (10), 641-648, 2015 | 9 | 2015 |
Pharmacokinetic/pharmaco–dynamic modelling and simulation of the effects of different cannabinoid receptor type 1 antagonists on Δ9‐tetrahydrocannabinol … Z Guan, LE Klumpers, OO Oyetayo, J Heuberger, JMA van Gerven, ... British journal of clinical pharmacology 81 (4), 713-723, 2016 | 3 | 2016 |
The Therapeutic Potential of Cannabis and the Endocannabinoid System LE Klumpers, A Hazekamp Principles and Practice of Botanicals as an Integrative Therapy, 393, 2019 | | 2019 |
Sex differences in clinical pharmacology and gender differences in society: How to give an emerging industry a head start L Klumpers ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
Shaping the bright future of the cannabis industry: Because we can L Klumpers, D Thacker, K Franson ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
Does 1+ 1= 3? What science really knows about cannabinoid and terpene effects in humans L Klumpers, K Franson ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 255, 2018 | | 2018 |
Namisol: een nieuwe formulering van delta⁹-tetrahydrocannabinol met gunstige farmacokinetiek en veelbelovende farmacodynamische effecten LE Klumpers, TL Beumer, JGC van Hasselt, A Lipplaa, LB Karger, ... PW Wetenschappelijk Platform 9 (6), 122-31, 2015 | | 2015 |
Novel approaches in clinical development of cannabinoid drugs LE Klumpers Leiden University, 2014 | | 2014 |
TETRAHYDROCANABINOL TABLET NAMISOL®: FIRST IN HUMAN PK, PD AND TOLERABILITY: 20 L Klumpers, T Beumer, L Karger, A Lipplaa, M de Kam, J van Gerven British Journal of Clinical Pharmacology 72 (5), 2011 | | 2011 |
First in human trial of an oral tablet with Δ9-THC (Namisol®): P2392 L Klumpers, J van Gerven, T Beumer European Journal of Neurology 17, 2010 | | 2010 |
FOCUSED CONFERENCE GROUP: PW03-TARGETING TRP CHANNELS FOR PAIN RELIEF (AND MORE) PHARMACOLOGICAL RESTING STATE-FMRI STUDY USING THC: Paper No.: 2734 L Klumpers, R Soeter, N Khalili-Mahani, S Rombouts, M van Buchem, ... Basic & Clinical Pharmacology & Toxicology 107, 380-381, 2010 | | 2010 |
Novel method in pharmacology research: resting state-functional Magnetic Resonance Imaging study using Delta 9-Tetrahydrocannabidiol L Klumpers, R Soeter, N Khalili-Mahani, M van Buchem, S Rombouts, ... | | 2010 |
P. 1. c. 037 Surinabant inhibits the effects of delta 9-tetrahydrocannabinol in a novel tetrahydrocannabinol-challenge test L Klumpers, C Roy, F Poitiers, S Turpault, JMA van Gerven European Neuropsychopharmacology, S240-S241, 2008 | | 2008 |