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Hidde Ploegh
Hidde Ploegh
Senior Investigator, Program in Cellular and Molecular Medicine, Boston Children's Hospital
Geverifieerd e-mailadres voor childrens.harvard.edu
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Molecular cell biology
HF Lodish
Macmillan, 2008
133032008
Genome-scale CRISPR-mediated control of gene repression and activation
LA Gilbert, MA Horlbeck, B Adamson, JE Villalta, Y Chen, EH Whitehead, ...
Cell 159 (3), 647-661, 2014
28132014
CX3CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
JH Niess, S Brand, X Gu, L Landsman, S Jung, BA McCormick, JM Vyas, ...
Science 307 (5707), 254-258, 2005
19452005
Sec6l-mediated transfer of a membrane protein from the endoplasmic reticulum to the proteasome for destruction
EJHJ Wiertz, D Tortorella, M Bogyo, J Yu, W Mothes, TR Jones, ...
Nature 384 (6608), 432-438, 1996
14371996
The human cytomegalovirus US11 gene product dislocates MHC class I heavy chains from the endoplasmic reticulum to the cytosol
EJHJ Wiertz, TR Jones, L Sun, M Bogyo, HJ Geuze, HL Ploegh
Cell 84 (5), 769-779, 1996
13851996
Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining
T Maruyama, SK Dougan, MC Truttmann, AM Bilate, JR Ingram, ...
Nature biotechnology 33 (5), 538-542, 2015
13362015
Empty MHC class I molecules come out in the cold
HG Ljunggren, NJ Stam, C Öhlén, JJ Neefjes, P Höglund, MT Heemels, ...
Nature 346 (6283), 476-480, 1990
11471990
Herpes simplex virus turns off the TAP to evade host immunity
A Hill, P Jugovic, lan York, G Russ, J Bennink, J Yewdell, H Ploegh, ...
Nature 375 (6530), 411-415, 1995
10811995
Viral subversion of the immune system
D Tortorella, BE Gewurz, MH Furman, DJ Schust, HL Ploegh
Annual review of immunology 18 (1), 861-926, 2000
10272000
Viral strategies of immune evasion
HL Ploegh
Science 280 (5361), 248-253, 1998
10131998
The known unknowns of antigen processing and presentation
JM Vyas, AG Van der Veen, HL Ploegh
Nature Reviews Immunology 8 (8), 607-618, 2008
9262008
TAP1 mutant mice are deficient in antigen presentation, surface class I molecules, and CD4− 8+ T cells
L Van Kaer, PG Ashton-Rickardt, HL Ploegh, S Tonegawa
Cell 71 (7), 1205-1214, 1992
8751992
A membrane protein required for dislocation of misfolded proteins from the ER
BN Lilley, HL Ploegh
Nature 429 (6994), 834-840, 2004
8612004
Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus
T Nakagawa, W Roth, P Wong, A Nelson, A Farr, J Deussing, ...
Science 280 (5362), 450-453, 1998
8591998
UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes
YM Kim, MM Brinkmann, ME Paquet, HL Ploegh
Nature 452 (7184), 234-238, 2008
8402008
Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments
PJ Peters, JJ Neefjes, V Oorschot, HL Ploegh, HJ Geuze
Nature 349 (6311), 669-676, 1991
8241991
An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration
SM Lehmann, C Krüger, B Park, K Derkow, K Rosenberger, J Baumgart, ...
Nature neuroscience 15 (6), 827-835, 2012
8022012
Road to ruin: targeting proteins for degradation in the endoplasmic reticulum
MH Smith, HL Ploegh, JS Weissman
Science 334 (6059), 1086-1090, 2011
7642011
Multiple associated proteins regulate proteasome structure and function
DS Leggett, J Hanna, A Borodovsky, B Crosas, M Schmidt, RT Baker, ...
Molecular cell 10 (3), 495-507, 2002
7602002
Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase
RA Gruters, JJ Neefjes, M Tersmette, REY de Goede, A Tulp, ...
Nature 330 (6143), 74-77, 1987
7451987
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