| The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans BJ Reinhart, FJ Slack, M Basson, AE Pasquinelli, JC Bettinger, ... nature 403 (6772), 901-906, 2000 | 6946 | 2000 |
| Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans B Wightman, I Ha, G Ruvkun Cell 75 (5), 855-862, 1993 | 5534 | 1993 |
| Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA AE Pasquinelli, BJ Reinhart, F Slack, MQ Martindale, MI Kuroda, B Maller, ... Nature 408 (6808), 86-89, 2000 | 3421 | 2000 |
| daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans KD Kimura, HA Tissenbaum, Y Liu, G Ruvkun Science 277 (5328), 942-946, 1997 | 2697 | 1997 |
| Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing A Grishok, AE Pasquinelli, D Conte, N Li, S Parrish, I Ha, DL Baillie, A Fire, ... Cell 106 (1), 23-34, 2001 | 2672 | 2001 |
| A uniform system for microRNA annotation V Ambros, B Bartel, DP Bartel, CB Burge, JC Carrington, X Chen, ... Rna 9 (3), 277-279, 2003 | 2534 | 2003 |
| The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans S Ogg, S Paradis, S Gottlieb, GI Patterson, L Lee, HA Tissenbaum, ... Nature 389 (6654), 994-999, 1997 | 2315 | 1997 |
| Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes K Ashrafi, FY Chang, JL Watts, AG Fraser, RS Kamath, J Ahringer, ... Nature 421 (6920), 268-272, 2003 | 1297 | 2003 |
| Physical and genetic characterization of symbiotic and auxotrophic mutants of Rhizobium meliloti induced by transposon Tn5 mutagenesis HM Meade, SR Long, GB Ruvkun, SE Brown, FM Ausubel Journal of bacteriology 149 (1), 114-122, 1982 | 1149 | 1982 |
| A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans JZ Morris, HA Tissenbaum, G Ruvkun Nature 382 (6591), 536-539, 1996 | 1136 | 1996 |
| A systematic RNAi screen identifies a critical role for mitochondria in C. elegans longevity SS Lee, RYN Lee, AG Fraser, RS Kamath, J Ahringer, G Ruvkun Nature genetics 33 (1), 40-48, 2003 | 1123 | 2003 |
| The lin-41 RBCC gene acts in the C. elegans heterochronic pathway between the let-7 regulatory RNA and the LIN-29 transcription factor FJ Slack, M Basson, Z Liu, V Ambros, HR Horvitz, G Ruvkun Molecular cell 5 (4), 659-669, 2000 | 1045 | 2000 |
| The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products W Herr, RA Sturm, RG Clerc, LM Corcoran, D Baltimore, PA Sharp, ... Genes Dev 2 (12A), 1513-6, 1988 | 948 | 1988 |
| Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor S Paradis, G Ruvkun Genes & development 12 (16), 2488-2498, 1998 | 920 | 1998 |
| Regulation of C. elegans life-span by insulinlike signaling in the nervous system CA Wolkow, KD Kimura, MS Lee, G Ruvkun Science 290 (5489), 147-150, 2000 | 837 | 2000 |
| A general method for site-directed mutagenesis in prokaryotes GB Ruvkun, FM Ausubel Nature 289 (5793), 85-88, 1981 | 824 | 1981 |
| DAF-16 target genes that control C. elegans life-span and metabolism SS Lee, S Kennedy, AC Tolonen, G Ruvkun science 300 (5619), 644-647, 2003 | 783 | 2003 |
| Identification of many microRNAs that copurify with polyribosomes in mammalian neurons J Kim, A Krichevsky, Y Grad, GD Hayes, KS Kosik, GM Church, G Ruvkun Proceedings of the National Academy of Sciences 101 (1), 360-365, 2004 | 777 | 2004 |
| Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family SB Pierce, M Costa, R Wisotzkey, S Devadhar, SA Homburger, ... Genes & development 15 (6), 672-686, 2001 | 764 | 2001 |
| A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans S Kennedy, D Wang, G Ruvkun Nature 427 (6975), 645-649, 2004 | 737 | 2004 |
