| Readily accessible bicyclononynes for bioorthogonal labeling and three-dimensional imaging of living cells J Dommerholt, S Schmidt, R Temming, LJA Hendriks, FPJT Rutjes, ... Angewandte Chemie (International ed. in English) 49 (49), 9422, 2010 | 821 | 2010 |
| Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+ 2) cycloaddition MF Debets, SS Van Berkel, S Schoffelen, FPJT Rutjes, JCM Van Hest, ... Chemical communications 46 (1), 97-99, 2010 | 652 | 2010 |
| Bioconjugation with strained alkenes and alkynes MF Debets, SS Van Berkel, J Dommerholt, ATJ Dirks, FPJT Rutjes, ... Accounts of chemical research 44 (9), 805-815, 2011 | 648 | 2011 |
| Strain-promoted 1, 3-dipolar cycloaddition of cycloalkynes and organic azides J Dommerholt, FPJT Rutjes, FL van Delft Cycloadditions in Bioorthogonal Chemistry, 57-76, 2016 | 424 | 2016 |
| Preventing thiol-yne addition improves the specificity of strain-promoted azide–alkyne cycloaddition R van Geel, GJM Pruijn, FL van Delft, WC Boelens Bioconjugate chemistry 23 (3), 392-398, 2012 | 323 | 2012 |
| Azide: a unique dipole for metal‐free bioorthogonal ligations MF Debets, CWJ van der Doelen, FPJT Rutjes, FL van Delft ChemBioChem 11 (9), 1168-1184, 2010 | 289 | 2010 |
| Protein modification by strain-promoted alkyne–nitrone cycloaddition X Ning, RP Temming, J Dommerholt, J Guo, DB Ania, MF Debets, ... Angewandte Chemie (International ed. in English) 49 (17), 3065, 2010 | 278 | 2010 |
| Metal‐free triazole formation as a tool for bioconjugation SS Van Berkel, ATJ Dirks, MF Debets, FL van Delft, JJLM Cornelissen, ... ChemBioChem 8 (13), 1504-1508, 2007 | 277 | 2007 |
| Expedient synthesis of triazole-linked glycosyl amino acids and peptides BHM Kuijpers, S Groothuys, ABR Keereweer, PJLM Quaedflieg, ... Organic letters 6 (18), 3123-3126, 2004 | 261 | 2004 |
| Chemoenzymatic conjugation of toxic payloads to the globally conserved N-glycan of native mAbs provides homogeneous and highly efficacious antibody–drug conjugates R Van Geel, MA Wijdeven, R Heesbeen, JMM Verkade, AA Wasiel, ... Bioconjugate chemistry 26 (11), 2233-2242, 2015 | 244 | 2015 |
| Targeting Aberrant Sialylation in Cancer Cells Using a Fluorinated Sialic Acid Analog Impairs Adhesion, Migration, and In Vivo Tumor Growth C Büll, TJ Boltje, M Wassink, AMA de Graaf, FL van Delft, MH den Brok, ... Molecular cancer therapeutics 12 (10), 1935-1946, 2013 | 195 | 2013 |
| Highly accelerated inverse electron-demand cycloaddition of electron-deficient azides with aliphatic cyclooctynes J Dommerholt, O Van Rooijen, A Borrmann, CF Guerra, FM Bickelhaupt, ... Nature Communications 5 (1), 5378, 2014 | 192 | 2014 |
| In situ phosphine oxide reduction: a catalytic Appel reaction HA van Kalkeren, SHAM Leenders, CRA Hommersom, FPJT Rutjes, ... Chemistry–A European Journal 17 (40), 11290-11295, 2011 | 189 | 2011 |
| Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes AM Jawalekar, E Reubsaet, FPJT Rutjes, FL van Delft Chemical communications 47 (11), 3198-3200, 2011 | 187 | 2011 |
| Genetic Encoding of a Bicyclo [6.1. 0] nonyne‐Charged Amino Acid Enables Fast Cellular Protein Imaging by Metal‐Free Ligation A Borrmann, S Milles, T Plass, J Dommerholt, JMM Verkade, M Wießler, ... ChemBioChem 13 (14), 2094-2099, 2012 | 182 | 2012 |
| 2-Deoxystreptamine: central scaffold of aminoglycoside antibiotics GF Busscher, FPJT Rutjes, FL Van Delft Chemical reviews 105 (3), 775-792, 2005 | 181 | 2005 |
| Preparation of biohybrid amphiphiles via the copper catalysed Huisgen [3+ 2] dipolar cycloaddition reaction SS ávan Berkel, FL ávan Delft, JLM Jeroen, JCM ávan Hest, PJT Floris, ... Chemical communications, 4172-4174, 2005 | 181 | 2005 |
| Biological relevance and synthesis of C-substituted morpholine derivatives R Wijtmans, MKS Vink, HE Schoemaker, FL van Delft, RH Blaauw, ... Synthesis 2004 (05), 641-662, 2004 | 155 | 2004 |
| Total synthesis of eleutherobin KC Nicolaou, F Van Delft, T Ohshima, D Vourloumis, J Xu, S Hosokawa, ... Angewandte Chemie International Edition in English 36 (22), 2520-2524, 1997 | 154 | 1997 |
| Conjugation of nucleosides and oligonucleotides by [3+ 2] cycloaddition AM Jawalekar, N Meeuwenoord, JSGO Cremers, HS Overkleeft, ... The Journal of organic chemistry 73 (1), 287-290, 2008 | 141 | 2008 |
