| MAGeCK enables robust identification of essential genes from genome-scale CRISPR/Cas9 knockout screens W Li, H Xu, T Xiao, L Cong, MI Love, F Zhang, RA Irizarry, JS Liu, ... Genome biology 15, 1-12, 2014 | 1832 | 2014 |
| Sequence determinants of improved CRISPR sgRNA design H Xu, T Xiao, CH Chen, W Li, CA Meyer, Q Wu, D Wu, L Cong, F Zhang, ... Genome research 25 (8), 1147-1157, 2015 | 654 | 2015 |
| Genome-scale deletion screening of human long non-coding RNAs using a paired-guide RNA CRISPR–Cas9 library S Zhu, W Li, J Liu, CH Chen, Q Liao, P Xu, H Xu, T Xiao, Z Cao, J Peng, ... Nature biotechnology 34 (12), 1279-1286, 2016 | 462 | 2016 |
| Quality control, modeling, and visualization of CRISPR screens with MAGeCK-VISPR W Li, J Köster, H Xu, CH Chen, T Xiao, JS Liu, M Brown, XS Liu Genome biology 16, 1-13, 2015 | 380 | 2015 |
| Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing T Fei, Y Chen, T Xiao, W Li, L Cato, P Zhang, MB Cotter, M Bowden, ... Proceedings of the National Academy of Sciences 114 (26), E5207-E5215, 2017 | 291 | 2017 |
| Integrative analysis of pooled CRISPR genetic screens using MAGeCKFlute B Wang, M Wang, W Zhang, T Xiao, CH Chen, A Wu, F Wu, N Traugh, ... Nature protocols 14 (3), 756-780, 2019 | 264 | 2019 |
| Allele-specific chromatin recruitment and therapeutic vulnerabilities of ESR1 activating mutations R Jeselsohn, JS Bergholz, M Pun, MI Cornwell, W Liu, A Nardone, T Xiao, ... Cancer cell 33 (2), 173-186. e5, 2018 | 234 | 2018 |
| Long noncoding RNA ADINR regulates adipogenesis by transcriptionally activating C/EBPα T Xiao, L Liu, H Li, Y Sun, H Luo, T Li, S Wang, S Dalton, RC Zhao, ... Stem cell reports 5 (5), 856-865, 2015 | 157 | 2015 |
| ARv7 represses tumor-suppressor genes in castration-resistant prostate cancer L Cato, J de Tribolet-Hardy, I Lee, JT Rottenberg, I Coleman, D Melchers, ... Cancer cell 35 (3), 401-413. e6, 2019 | 152 | 2019 |
| Inactivation of the PBRM1 tumor suppressor gene amplifies the HIF-response in VHL−/− clear cell renal carcinoma Wenhua Gao, Wei Li, Tengfei Xiao, Xiaole Shirley Liu, and William G. Kaelin Proceedings of the National Academy of Sciences 114 (5), 1027-1032, 2017 | 151 | 2017 |
| Synthetic lethal and resistance interactions with BET bromodomain inhibitors in triple-negative breast cancer S Shu, HJ Wu, YG Jennifer, R Zeid, IS Harris, B Jovanović, K Murphy, ... Molecular cell 78 (6), 1096-1113. e8, 2020 | 130 | 2020 |
| Merkel cell polyomavirus recruits MYCL to the EP400 complex to promote oncogenesis J Cheng, DE Park, C Berrios, EA White, R Arora, R Yoon, T Branigan, ... PLoS pathogens 13 (10), e1006668, 2017 | 111 | 2017 |
| In vivo CRISPR screens identify the E3 ligase Cop1 as a modulator of macrophage infiltration and cancer immunotherapy target X Wang, C Tokheim, SS Gu, B Wang, Q Tang, Y Li, N Traugh, Z Zeng, ... Cell 184 (21), 5357-5374. e22, 2021 | 87 | 2021 |
| Pharmacological inhibition of β-catenin/BCL9 interaction overcomes resistance to immune checkpoint blockades by modulating Treg cells M Feng, JQ Jin, L Xia, T Xiao, S Mei, X Wang, X Huang, J Chen, M Liu, ... Science advances 5 (5), eaau5240, 2019 | 85 | 2019 |
| Modeling cis-regulation with a compendium of genome-wide histone H3K27ac profiles S Wang, C Zang, T Xiao, J Fan, S Mei, Q Qin, Q Wu, X Li, K Xu, HH He, ... Genome research 26 (10), 1417-1429, 2016 | 81 | 2016 |
| Estrogen receptor signaling is reprogrammed during breast tumorigenesis D Chi, H Singhal, L Li, T Xiao, W Liu, M Pun, R Jeselsohn, H He, E Lim, ... Proceedings of the National Academy of Sciences 116 (23), 11437-11443, 2019 | 73 | 2019 |
| Estrogen-regulated feedback loop limits the efficacy of estrogen receptor–targeted breast cancer therapy T Xiao, W Li, X Wang, H Xu, J Yang, Q Wu, Y Huang, J Geradts, P Jiang, ... Proceedings of the National Academy of Sciences 115 (31), 7869-7878, 2018 | 65 | 2018 |
| Transcriptional profiling analysis and functional prediction of long noncoding RNAs in cancer J Yuan, H Yue, M Zhang, J Luo, L Liu, W Wu, T Xiao, X Chen, X Chen, ... Oncotarget 7 (7), 8131, 2016 | 57 | 2016 |
| Improved design and analysis of CRISPR knockout screens CH Chen, T Xiao, H Xu, P Jiang, CA Meyer, W Li, M Brown, XS Liu Bioinformatics 34 (23), 4095-4101, 2018 | 52 | 2018 |
| ERCC6L2 promotes DNA orientation-specific recombination in mammalian cells X Liu, T Liu, Y Shang, P Dai, W Zhang, BJ Lee, M Huang, D Yang, Q Wu, ... Cell research 30 (9), 732-744, 2020 | 46 | 2020 |
Myles BrownEmil Frei III Professor of Medicine, Dana-Farber Cancer Institute and Harvard Medical SchoolVerified email at dfci.harvard.edu
