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Marte Innselset Flydal
Marte Innselset Flydal
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Phenylalanine hydroxylase: function, structure, and regulation
MI Flydal, A Martinez
IUBMB life 65 (4), 341-349, 2013
2212013
Structure of phenylalanine hydroxylase from Colwellia psychrerythraea 34H, a monomeric cold active enzyme with local flexibility around the active site and high overall stability
HKS Leiros, AL Pey, M Innselset, E Moe, I Leiros, IH Steen, A Martinez
Journal of Biological Chemistry 282 (30), 21973-21986, 2007
842007
Arc is a flexible modular protein capable of reversible self-oligomerization
C Myrum, A Baumann, HJ Bustad, MI Flydal, V Mariaule, S Alvira, ...
Biochemical Journal 468 (1), 145-158, 2015
742015
Structure of full-length human phenylalanine hydroxylase in complex with tetrahydrobiopterin
MI Flydal, M Alcorlo-Pagés, FG Johannessen, S Martínez-Caballero, ...
Proceedings of the National Academy of Sciences 116 (23), 11229-11234, 2019
572019
Brain catecholamine depletion and motor impairment in a Th knock-in mouse with type B tyrosine hydroxylase deficiency
G Korner, D Noain, M Ying, M Hole, MI Flydal, T Scherer, G Allegri, ...
Brain 138 (10), 2948-2963, 2015
412015
Stable preparations of tyrosine hydroxylase provide the solution structure of the full-length enzyme
MT Bezem, A Baumann, L Skjærven, R Meyer, P Kursula, A Martinez, ...
Scientific reports 6 (1), 30390, 2016
342016
Structural mechanism for tyrosine hydroxylase inhibition by dopamine and reactivation by Ser40 phosphorylation
MT Bueno-Carrasco, J Cuéllar, MI Flydal, C Santiago, TA Kråkenes, ...
Nature communications 13 (1), 74, 2022
332022
Arc self‐association and formation of virus‐like capsids are mediated by an N‐terminal helical coil motif
MS Eriksen, O Nikolaienko, EI Hallin, S Grødem, HJ Bustad, MI Flydal, ...
The FEBS journal 288 (9), 2930-2955, 2021
282021
Phenylalanine Hydroxylase from Legionella pneumophila Is a Thermostable Enzyme with a Major Functional Role in Pyomelanin Synthesis
MI Flydal, CH Chatfield, H Zheng, FF Gunderson, O Aubi, NP Cianciotto, ...
Public Library of Science 7 (9), e46209, 2012
282012
Regulation of tyrosine hydroxylase is preserved across different homo-and heterodimeric 14-3-3 proteins
S Ghorbani, A Fossbakk, A Jorge-Finnigan, MI Flydal, J Haavik, R Kleppe
Amino acids 48, 1221-1229, 2016
262016
Superstoichiometric binding of L-Phe to phenylalanine hydroxylase from Caenorhabditis elegans: evolutionary implications
MI Flydal, TC Mohn, AL Pey, J Siltberg-Liberles, K Teigen, A Martinez
Amino Acids 39, 1463-1475, 2010
192010
The Host-Pathogen interaction of Human Cyclophilin A and HIV-1 Vpr requires specific N-terminal and novel C-terminal domains
SMO Solbak, V Wray, O Horvli, AJ Raae, MI Flydal, P Henklein, ...
BMC structural biology 11 (1), 49, 2011
182011
Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila
O Aubi, MI Flydal, H Zheng, L Skjærven, I Rekand, HKS Leiros, BE Haug, ...
Journal of medicinal chemistry 58 (21), 8402-8412, 2015
172015
Personalized medicine to improve treatment of dopa-responsive dystonia—a focus on tyrosine hydroxylase deficiency
G Nygaard, PD Szigetvari, AK Grindheim, P Ruoff, A Martinez, J Haavik, ...
Journal of Personalized Medicine 11 (11), 1186, 2021
122021
Levalbuterol lowers the feedback inhibition by dopamine and delays misfolding and aggregation in tyrosine hydroxylase
MI Flydal, TA Kråkenes, MDS Tai, MPA Tran, K Teigen, A Martinez
Biochimie 183, 126-132, 2021
122021
Inhibition of the human hsc70 system by small ligands as a potential anticancer approach
L Dublang, J Underhaug, MI Flydal, L Velasco-Carneros, JD Maréchal, ...
Cancers 13 (12), 2936, 2021
112021
New perspectives for pharmacological chaperoning treatment in methylmalonic aciduria cblB type
S Brasil, A Briso-Montiano, A Gámez, J Underhaug, MI Flydal, L Desviat, ...
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1864 (2), 640-648, 2018
102018
Differential scanning fluorimetry in the screening and validation of pharmacological chaperones for soluble and membrane proteins
SI Støve, MI Flydal, E Hausvik, J Underhaug, A Martinez
Protein Homeostasis Diseases, 329-341, 2020
82020
Characterization of the Cdc6 Homologues from the Euryarchaeon Thermoplasma acidophilum
GT Haugland, M Innselset, D Madern, NK Birkeland
The Open Biochemistry Journal 2, 129, 2008
62008
Structural and thermodynamic insight into phenylalanine hydroxylase from the human pathogen Legionella pneumophila
HKS Leiros, MI Flydal, A Martinez
FEBS Open bio 3, 370-378, 2013
52013
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Artikelen 1–20