Sato Toshiro
Sato Toshiro
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Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
T Sato, RG Vries, HJ Snippert, M Van De Wetering, N Barker, DE Stange, ...
Nature 459 (7244), 262-265, 2009
Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett's epithelium
T Sato, DE Stange, M Ferrante, RGJ Vries, JH Van Es, S Van Den Brink, ...
Gastroenterology 141 (5), 1762-1772, 2011
Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
T Sato, JH Van Es, HJ Snippert, DE Stange, RG Vries, M Van Den Born, ...
Nature 469 (7330), 415-418, 2011
Intestinal crypt homeostasis results from neutral competition between symmetrically dividing Lgr5 stem cells
HJ Snippert, LG Van Der Flier, T Sato, JH Van Es, M Van Den Born, ...
Cell 143 (1), 134-144, 2010
Lgr5+ ve stem cells drive self-renewal in the stomach and build long-lived gastric units in vitro
N Barker, M Huch, P Kujala, M van de Wetering, HJ Snippert, JH van Es, ...
Cell stem cell 6 (1), 25-36, 2010
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
M Huch, C Dorrell, SF Boj, JH Van Es, VSW Li, M Van De Wetering, ...
Nature 494 (7436), 247-250, 2013
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications
T Sato, H Clevers
Science 340 (6137), 1190-1194, 2013
Modeling colorectal cancer using CRISPR-Cas9–mediated engineering of human intestinal organoids
M Matano, S Date, M Shimokawa, A Takano, M Fujii, Y Ohta, T Watanabe, ...
Nature medicine 21 (3), 256-262, 2015
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
S Yui, T Nakamura, T Sato, Y Nemoto, T Mizutani, X Zheng, S Ichinose, ...
Nature medicine 18 (4), 618-623, 2012
Tissue-specific mutation accumulation in human adult stem cells during life
F Blokzijl, J De Ligt, M Jager, V Sasselli, S Roerink, N Sasaki, M Huch, ...
Nature 538 (7624), 260-264, 2016
Unique CD14+ intestinal macrophages contribute to the pathogenesis of Crohn disease via IL-23/IFN-γ axis
N Kamada, T Hisamatsu, S Okamoto, H Chinen, T Kobayashi, T Sato, ...
The Journal of clinical investigation 118 (6), 2269-2280, 2008
Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
JH Van Es, T Sato, M Van De Wetering, A Lyubimova, AN Yee Nee, ...
Nature cell biology 14 (10), 1099-1104, 2012
Isolation and in vitro expansion of human colonic stem cells
P Jung, T Sato, A Merlos-Suárez, FM Barriga, M Iglesias, D Rossell, ...
Nature medicine 17 (10), 1225-1227, 2011
Unlimited in vitro expansion of adult bi‐potent pancreas progenitors through the Lgr5/R‐spondin axis
M Huch, P Bonfanti, SF Boj, T Sato, CJM Loomans, M Van De Wetering, ...
The EMBO journal 32 (20), 2708-2721, 2013
A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis
M Fujii, M Shimokawa, S Date, A Takano, M Matano, K Nanki, Y Ohta, ...
Cell stem cell 18 (6), 827-838, 2016
Visualization and targeting of LGR5+ human colon cancer stem cells
M Shimokawa, Y Ohta, S Nishikori, M Matano, A Takano, M Fujii, S Date, ...
Nature 545 (7653), 187-192, 2017
Mapping the human genetic architecture of COVID-19
Writing group Writing group leaders Pathak Gita A. 6 Andrews Shea J. 7 Kanai ...
Nature 600 (7889), 472-477, 2021
PTEN-deficient intestinal stem cells initiate intestinal polyposis
XC He, T Yin, JC Grindley, Q Tian, T Sato, WA Tao, R Dirisina, ...
Nature genetics 39 (2), 189-198, 2007
Current view: intestinal stem cells and signaling
DH Scoville, T Sato, XC He, L Li
Gastroenterology 134 (3), 849-864, 2008
Human pancreatic tumor organoids reveal loss of stem cell niche factor dependence during disease progression
T Seino, S Kawasaki, M Shimokawa, H Tamagawa, K Toshimitsu, M Fujii, ...
Cell stem cell 22 (3), 454-467. e6, 2018
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