Peter Kirwan
Peter Kirwan
WT-MRC Institute of Metabolic Science, Cambridge
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Human cerebral cortex development from pluripotent stem cells to functional excitatory synapses
Y Shi, P Kirwan, J Smith, HPC Robinson, FJ Livesey
Nature neuroscience 15 (3), 477-486, 2012
Directed differentiation of human pluripotent stem cells to cerebral cortex neurons and neural networks
Y Shi, P Kirwan, FJ Livesey
Nature protocols 7 (10), 1836-1846, 2012
A human stem cell model of early Alzheimer’s disease pathology in Down syndrome
Y Shi, P Kirwan, J Smith, G MacLean, SH Orkin, FJ Livesey
Science translational medicine 4 (124), 124ra29-124ra29, 2012
APP metabolism regulates tau proteostasis in human cerebral cortex neurons
S Moore, LDB Evans, T Andersson, E Portelius, J Smith, TB Dias, ...
Cell reports 11 (5), 689-696, 2015
Development and function of human cerebral cortex neural networks from pluripotent stem cells in vitro
P Kirwan, B Turner-Bridger, M Peter, A Momoh, D Arambepola, ...
Development 142 (18), 3178-3187, 2015
The phosphorylation status of Ascl1 is a key determinant of neuronal differentiation and maturation in vivo and in vitro
FR Ali, K Cheng, P Kirwan, S Metcalfe, FJ Livesey, RA Barker, A Philpott
Development 141 (11), 2216-2224, 2014
Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis
P Kirwan, RG Kay, B Brouwers, V Herranz-Pérez, M Jura, P Larraufie, ...
Molecular metabolism 17, 82-97, 2018
Rapid sensing of l-leucine by human and murine hypothalamic neurons: neurochemical and mechanistic insights
N Heeley, P Kirwan, T Darwish, M Arnaud, ML Evans, FT Merkle, ...
Molecular metabolism 10, 14-27, 2018
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities
T Sonoyama, LKJ Stadler, M Zhu, JM Keogh, E Henning, F Hisama, ...
Scientific reports 10 (1), 1-14, 2020
Generation and characterization of functional human hypothalamic neurons
P Kirwan, M Jura, FT Merkle
Current protocols in neuroscience 81 (1), 3.33. 1-3.33. 24, 2017
Proopiomelanocortin processing in the hypothalamus is directly regulated by saturated fat: Implications for the development of obesity
DS Razolli, TM de Araújo, MR Sant'Ana, P Kirwan, DE Cintra, FT Merkle, ...
Neuroendocrinology 110 (1-2), 92-104, 2020
Human POMC processing in vitro and in vivo revealed by quantitative peptidomics
P Kirwan, R Kay, B Brouwers, V Herranz-Perez, M Jura, P Larraufie, ...
bioRxiv, 257121, 2018
Human Stem Cell Models of Neurodevelopmental Disorders
P Kirwan, FJ Livesey
The Genetics of Neurodevelopmental Disorders, 239, 2015
Development and function of human cerebral cortex neuronal networks from pluripotent stem cells
M Peter, P Kirwan, R Livesey
Proceedings of The Physiological Society, 2015
Modelling human cortical networks in development and Down syndrome using pluripotent stem cells
P Kirwan
University of Cambridge, 2014
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