sylvain Ladame
sylvain Ladame
Lecturer in Biosensor Development, Department of Bioengineering, Imperial College London
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Putative DNA Quadruplex Formation within the Human c-kit Oncogene
S Rankin, AP Reszka, J Huppert, M Zloh, GN Parkinson, AK Todd, ...
Journal of the American Chemical Society 127 (30), 10584-10589, 2005
A conserved quadruplex motif located in a transcription activation site of the human c-kit oncogene
H Fernando, AP Reszka, J Huppert, S Ladame, S Rankin, ...
Biochemistry 45 (25), 7854-7860, 2006
Dynamic combinatorial chemistry: on the road to fulfilling the promise
S Ladame
Organic & biomolecular chemistry 6 (2), 219-226, 2008
Macrocyclic and helical oligoamides as a new class of G-quadruplex ligands
PS Shirude, ER Gillies, S Ladame, F Godde, K Shin-Ya, I Huc, ...
Journal of the American Chemical Society 129 (39), 11890-11891, 2007
Enhanced chemical synthesis at soft interfaces: A universal reaction-adsorption mechanism in microcompartments
A Fallah-Araghi, K Meguellati, JC Baret, A El Harrak, T Mangeat, ...
Physical review letters 112 (2), 028301, 2014
Oxazole-based peptide macrocycles: a new class of G-quadruplex binding ligands
K Jantos, R Rodriguez, S Ladame, PS Shirude, S Balasubramanian
Journal of the American Chemical Society 128 (42), 13662-13663, 2006
DNA‐templated synthesis of trimethine cyanine dyes: a versatile fluorogenic reaction for sensing G‐quadruplex formation
K Meguellati, G Koripelly, S Ladame
Angewandte Chemie 122 (15), 2798-2802, 2010
Templated ligand assembly by using G‐quadruplex DNA and dynamic covalent chemistry
AM Whitney, S Ladame, S Balasubramanian
Angewandte Chemie International Edition 43 (9), 1143-1146, 2004
First evidence of a functional interaction between DNA quadruplexes and poly (ADP-ribose) polymerase-1
VA Soldatenkov, AA Vetcher, T Duka, S Ladame
ACS chemical biology 3 (4), 214-219, 2008
G-quadruplex-specific peptide− hemicyanine ligands by partial combinatorial selection
JA Schouten, S Ladame, SJ Mason, MA Cooper, S Balasubramanian
Journal of the American Chemical Society 125 (19), 5594-5595, 2003
Synthesis and G-quadruplex binding studies of new 4-N-methylpyridinium porphyrins
DPN Gonçalves, S Ladame, S Balasubramanian, JKM Sanders
Organic & biomolecular chemistry 4 (17), 3337-3342, 2006
Recognition and discrimination of DNA quadruplexes by acridine-peptide conjugates
JE Redman, JM Granadino-Roldan, JA Schouten, S Ladame, AP Reszka, ...
Organic & biomolecular chemistry 7 (1), 76-84, 2009
Targeting nucleic acid secondary structures with polyamides using an optimized dynamic combinatorial approach
S Ladame, AM Whitney, S Balasubramanian
Angewandte Chemie 117 (35), 5882-5885, 2005
Combining G-quadruplex targeting motifs on a single peptide nucleic acid scaffold: a hybrid (3+ 1) PNA-DNA bimolecular quadruplex
A Paul, P Sengupta, Y Krishnan, S Ladame
Hydrogel-coated microneedle arrays for minimally invasive sampling and sensing of specific circulating nucleic acids from skin interstitial fluid
D Al Sulaiman, JYH Chang, NR Bennett, H Topouzi, CA Higgins, DJ Irvine, ...
ACS nano 13 (8), 9620-9628, 2019
Synthesis and spectroscopic and DNA-binding properties of fluorogenic acridine-containing cyanine dyes
T Mahmood, A Paul, S Ladame
The Journal of organic chemistry 75 (1), 204-207, 2010
Amplification-free detection of circulating microRNA biomarkers from body fluids based on fluorogenic oligonucleotide-templated reaction between engineered peptide nucleic acid …
GAD Metcalf, A Shibakawa, H Patel, A Sita-Lumsden, A Zivi, N Rama, ...
Analytical chemistry 88 (16), 8091-8098, 2016
Inhibition of human telomerase activity by an engineered zinc finger protein that binds G-quadruplexes
SD Patel, M Isalan, G Gavory, S Ladame, Y Choo, S Balasubramanian
Biochemistry 43 (42), 13452-13458, 2004
Crystal structure of Trypanosoma cruzi glyceraldehyde‐3‐phosphate dehydrogenase complexed with an analogue of 1,3‐bisphospho‐d‐glyceric acid: Selective …
S Ladame, MS Castilho, CHTP Silva, C Denier, V Hannaert, J Périé, ...
European journal of biochemistry 270 (22), 4574-4586, 2003
Oligonucleotide-templated chemical reactions: pushing the boundaries of a nature-inspired process
C Percivalle, JF Bartolo, S Ladame
Organic & biomolecular chemistry 11 (1), 16-26, 2013
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