Walter M. van Gulik
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Quantitative analysis of the microbial metabolome by isotope dilution mass spectrometry using uniformly 13C-labeled cell extracts as internal standards
L Wu, MR Mashego, JC van Dam, AM Proell, JL Vinke, C Ras, ...
Analytical biochemistry 336 (2), 164-171, 2005
Fumaric acid production by fermentation
CA Roa Engel, AJJ Straathof, TW Zijlmans, WM van Gulik, ...
Applied microbiology and biotechnology 78, 379-389, 2008
Quantitative evaluation of intracellular metabolite extraction techniques for yeast metabolomics
AB Canelas, A ten Pierick, C Ras, RM Seifar, JC van Dam, WM van Gulik, ...
Analytical chemistry 81 (17), 7379-7389, 2009
Role of transcriptional regulation in controlling fluxes in central carbon metabolism of Saccharomyces cerevisiae: a chemostat culture study
P Daran-Lapujade, MLA Jansen, JM Daran, W van Gulik, JH de Winde, ...
Journal of Biological Chemistry 279 (10), 9125-9138, 2004
MIRACLE: mass isotopomer ratio analysis of U‐13C‐labeled extracts. A new method for accurate quantification of changes in concentrations of intracellular …
MR Mashego, L Wu, JC Van Dam, C Ras, JL Vinke, WA Van Winden, ...
Biotechnology and bioengineering 85 (6), 620-628, 2004
Leakage-free rapid quenching technique for yeast metabolomics
AB Canelas, C Ras, A Ten Pierick, JC van Dam, JJ Heijnen, ...
Metabolomics 4, 226-239, 2008
The fluxes through glycolytic enzymes in Saccharomyces cerevisiae are predominantly regulated at posttranscriptional levels
P Daran-Lapujade, S Rossell, WM van Gulik, MAH Luttik, MJL de Groot, ...
Proceedings of the National Academy of Sciences 104 (40), 15753-15758, 2007
A metabolic network stoichiometry analysis of microbial growth and product formation
WM Van Gulik, JJ Heijnen
Biotechnology and bioengineering 48 (6), 681-698, 1995
Towards large scale fermentative production of succinic acid
MLA Jansen, WM van Gulik
Current opinion in biotechnology 30, 190-197, 2014
Metabolic-flux analysis of Saccharomyces cerevisiae CEN.PK113-7D based on mass isotopomer measurements of 13C-labeled primary metabolites
WA Van Winden, JC Van Dam, C Ras, RJ Kleijn, JL Vinke, WM Van Gulik, ...
FEMS yeast research 5 (6-7), 559-568, 2005
Development and application of a differential method for reliable metabolome analysis in Escherichia coli
H Taymaz-Nikerel, M De Mey, C Ras, A ten Pierick, RM Seifar, ...
Analytical biochemistry 386 (1), 9-19, 2009
Measuring enzyme activities under standardized in vivo‐like conditions for systems biology
K Van Eunen, J Bouwman, P Daran‐Lapujade, J Postmus, AB Canelas, ...
The FEBS journal 277 (3), 749-760, 2010
Termination of trial of streptokinase in severe acute ischaemic stroke
M Hommel, JP Boissel, C Cornu, F Boutitie, KR Lees, G Besson, D Leys, ...
The Lancet 345 (8941), 57, 1995
Application of metabolic flux analysis for the identification of metabolic bottlenecks in the biosynthesis of penicillin‐G
WM Van Gulik, W De Laat, JL Vinke, JJ Heijnen
Biotechnology and Bioengineering 68 (6), 602-618, 2000
Determination of the cytosolic free NAD/NADH ratio in Saccharomyces cerevisiae under steady‐state and highly dynamic conditions
AB Canelas, WM van Gulik, JJ Heijnen
Biotechnology and bioengineering 100 (4), 734-743, 2008
Critical evaluation of sampling techniques for residual glucose determination in carbon‐limited chemostat culture of Saccharomyces cerevisiae
MR Mashego, WM Van Gulik, JL Vinke, JJ Heijnen
Biotechnology and bioengineering 83 (4), 395-399, 2003
Fast sampling for quantitative microbial metabolomics
WM Van Gulik
Current opinion in biotechnology 21 (1), 27-34, 2010
Rapid sampling for analysis of in vivo kinetics using the BioScope: a system for continuous‐pulse experiments
D Visser, GA van Zuylen, JC van Dam, A Oudshoorn, MR Eman, C Ras, ...
Biotechnology and bioengineering 79 (6), 674-681, 2002
Plant biotechnology for the production of alkaloids: present status and prospects
R Verpoorte, R van der Heijden, WM van Gulik, HJG ten Hoopen
The alkaloids: chemistry and pharmacology 40, 1-187, 1991
An in vivo data-driven framework for classification and quantification of enzyme kinetics and determination of apparent thermodynamic data
AB Canelas, C Ras, A ten Pierick, WM van Gulik, JJ Heijnen
Metabolic engineering 13 (3), 294-306, 2011
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