| Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction M Martignoni, GMM Groothuis, R de Kanter Expert opinion on drug metabolism & toxicology 2 (6), 875-894, 2006 | 1540 | 2006 |
| Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating … P Godoy, NJ Hewitt, U Albrecht, ME Andersen, N Ansari, S Bhattacharya, ... Archives of toxicology 87, 1315-1530, 2013 | 1389 | 2013 |
| Primary hepatocytes: current understanding of the regulation of metabolic enzymes and transporter proteins, and pharmaceutical practice for the use of hepatocytes in metabolism … NJ Hewitt, MJ Gómez Lechón, JB Houston, D Hallifax, HS Brown, ... Drug metabolism reviews 39 (1), 159-234, 2007 | 843 | 2007 |
| Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport RPJO Elferink, DKF Meijer, F Kuipers, PLM Jansen, AK Groen, ... Biochimica et Biophysica Acta (BBA)-Reviews on Biomembranes 1241 (2), 215-268, 1995 | 493 | 1995 |
| Preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies IAM De Graaf, P Olinga, MH De Jager, MT Merema, R De Kanter, ... Nature protocols 5 (9), 1540-1551, 2010 | 463 | 2010 |
| Procalcitonin behaves as a fast responding acute phase proteinin vivoandin vitro MWN Nijsten, P Olinga, EGE de Vries, HS Koops, GMM Groothuis, ... Critical care medicine 28 (2), 458-461, 2000 | 454 | 2000 |
| Comparison of biocompatibility and adsorption properties of different plastics for advanced microfluidic cell and tissue culture models PM van Midwoud, A Janse, MT Merema, GMM Groothuis, E Verpoorte Analytical chemistry 84 (9), 3938-3944, 2012 | 289 | 2012 |
| Caffeine-Based Gold(I) N-Heterocyclic Carbenes as Possible Anticancer Agents: Synthesis and Biological Properties B Bertrand, L Stefan, M Pirrotta, D Monchaud, E Bodio, P Richard, ... Inorganic chemistry 53 (4), 2296-2303, 2014 | 254 | 2014 |
| Drug uptake systems in liver and kidney JE van Montfoort, B Hagenbuch, GMM Groothuis, H Koepsell, PJ Meier, ... Current drug metabolism 4 (3), 185-211, 2003 | 249 | 2003 |
| A microfluidic approach for in vitro assessment of interorgan interactions in drug metabolism using intestinal and liver slices PM van Midwoud, MT Merema, E Verpoorte, GMM Groothuis Lab on a Chip 10 (20), 2778-2786, 2010 | 234 | 2010 |
| LPS-induced downregulation of MRP2 and BSEP in human liver is due to a posttranscriptional process MGL Elferink, P Olinga, AL Draaisma, MT Merema, KN Faber, MJH Slooff, ... American Journal of Physiology-Gastrointestinal and Liver Physiology 287 (5 …, 2004 | 229 | 2004 |
| Targeting oxidative stress for the treatment of liver fibrosis T Luangmonkong, S Suriguga, HAM Mutsaers, GMM Groothuis, P Olinga, ... Reviews of Physiology, Biochemistry and Pharmacology, Vol. 175, 71-102, 2018 | 225 | 2018 |
| Albumin Modified With Mannose 6–Phosphate: A Potential Carrier for Selective Delivery of Antifibrotic Drugs to Rat and Human Hepatic Stellate Cells L Beljaars, G Molema, B Weert, H Bonnema, P Olinga, GM Groothuis, ... Hepatology 29 (5), 1486-1493, 1999 | 222 | 1999 |
| Precision-cut tissue slices as a tool to predict metabolism of novel drugs IAM Graaf, GMM Groothuis, P Olinga Expert opinion on drug metabolism & toxicology 3 (6), 879-898, 2007 | 175 | 2007 |
| Autoradiographic and kinetic demonstration of acinar heterogeneity of taurocholate transport GM Groothuis, MJ Hardonk, KP Keulemans, P Nieuwenhuis, DK Meijer American Journal of Physiology-Gastrointestinal and Liver Physiology 243 (6 …, 1982 | 168 | 1982 |
| Microfluidic biochip for the perifusion of precision‐cut rat liver slices for metabolism and toxicology studies PM Van Midwoud, GMM Groothuis, MT Merema, E Verpoorte Biotechnology and bioengineering 105 (1), 184-194, 2010 | 165 | 2010 |
| Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary‐conjugated hyperbilirubinemia PLM Jansen, GMM Groothuis, WHM Peters, DFM Meijer Hepatology 7 (1), 71-76, 1987 | 164 | 1987 |
| Targeting dexamethasone to Kupffer cells: effects on liver inflammation and fibrosis in rats BN Melgert, P Olinga, JMS Van Der Laan, B Weert, J Cho, D Schuppan, ... Hepatology 34 (4), 719-728, 2001 | 147 | 2001 |
| Precision-cut organ slices as a tool to study toxicity and metabolism of xenobiotics with special reference to non-hepatic tissues R Kanter, M Monshouwer, DKF Meijer, GMM Groothuis Current drug metabolism 3 (1), 39-59, 2002 | 146 | 2002 |
| Microfluidic devices for in vitro studies on liver drug metabolism and toxicity PM van Midwoud, E Verpoorte, GMM Groothuis Integrative Biology 3 (5), 509-521, 2011 | 142 | 2011 |
