Stephen Douthwaite
Stephen Douthwaite
Professor of Molecular Microbiology, University of Southern Denmark
Geverifieerd e-mailadres voor bmb.sdu.dk
TitelGeciteerd doorJaar
Macrolide resistance conferred by base substitutions in 23S rRNA
B Vester, S Douthwaite
Antimicrobial Agents and Chemotherapy 45 (1), 1-12, 2001
5832001
The bacterial ribosome as a target for antibiotics
J Poehlsgaard, S Douthwaite
Nature Reviews Microbiology 3 (11), 870-881, 2005
5272005
The macrolide–ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
LH Hansen, P Mauvais, S Douthwaite
Molecular microbiology 31 (2), 623-631, 1999
3491999
Basis for prokaryotic specificity of action of aminoglycoside antibiotics
MI Recht, S Douthwaite, JD Puglisi
The EMBO journal 18 (11), 3133-3138, 1999
2571999
Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2′-O-methylations in 16S and 23S rRNAs
SK Johansen, CE Maus, BB Plikaytis, S Douthwaite
Molecular cell 23 (2), 173-182, 2006
2402006
Macrolide–ketolide inhibition of MLS‐resistant ribosomes is improved by alternative drug interaction with domain II of 23S rRNA
S Douthwaite, LH Hansen, P Mauvais
Molecular microbiology 36 (1), 183-193, 2000
2242000
The ketolides
GG Zhanel, M Walters, A Noreddin, LM Vercaigne, A Wierzbowski, ...
Drugs 62 (12), 1771-1804, 2002
2182002
Oxazolidinone Resistance Mutations in 23S rRNA ofEscherichia coli Reveal the Central Region of Domain V as the Primary Site of Drug Action
L Xiong, P Kloss, S Douthwaite, NM Andersen, S Swaney, ...
Journal of bacteriology 182 (19), 5325-5331, 2000
1922000
A “bulged” double helix in a RNA-protein contact site
DA Peattie, S Douthwaite, RA Garrett, HF and Noller
Proc. Natl. Acad. Sci. USA 78, 7331-7335, 1981
1661981
The ribosome: structure, function, antibiotics, and cellular interactions
R Garrett, S Douthwaite, A Liljas, A Matheson, P Moore, H Noller
ASM Press, 2000
154*2000
Characterization of the binding sites of protein L11 and the L10.(L12) 4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli
J Egebjerg, SR Douthwaite, A Liljas, RA Garrett
Journal of molecular biology 213 (2), 275-288, 1990
1471990
The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A
G Rosendahl, S Douthwaite
Nucleic acids research 22 (3), 357-363, 1994
1331994
LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage
B Vester, LB Lundberg, MD Sørensen, BR Babu, S Douthwaite, J Wengel
Journal of the American Chemical Society 124 (46), 13682-13683, 2002
1322002
Structures of ketolides and macrolides determine their mode of interaction with the ribosomal target site
S Douthwaite, WS Champney
Journal of Antimicrobial Chemotherapy 48 (90002), 1-8, 2001
1322001
Mapping posttranscriptional modifications in 5S ribosomal RNA by MALDI mass spectrometry.
F Kirpekar, S Douthwaite, P Roepstorff
RNA 6 (2), 296-306, 2000
1322000
Macrolide resistance by ribosomal mutation in clinical isolates of Streptococcus pneumoniae from the PROTEKT 1999-2000 study
DJ Farrell, S Douthwaite, I Morrissey, S Bakker, J Poehlsgaard, ...
Antimicrobial agents and chemotherapy 47 (6), 1777-1783, 2003
1252003
Interconversion of active and inactive 30 S ribosomal subunits is accompanied by a conformational change in the decoding region of 16 S rRNA
D Moazed, BJ Van Stolk, S Douthwaite, HF Noller
Journal of molecular biology 191 (3), 483-493, 1986
1211986
Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction
MI Recht, S Douthwaite, KD Dahlquist, JD Puglisi
Journal of molecular biology 286 (1), 33-43, 1999
1181999
Functional interactions within 23S rRNA involving the peptidyltransferase center.
S Douthwaite
Journal of bacteriology 174 (4), 1333-1338, 1992
1181992
YebU is a m5C methyltransferase specific for 16S rRNA nucleotide 1407
NM Andersen, S Douthwaite
Journal of molecular biology 359 (3), 777-786, 2006
1122006
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Artikelen 1–20