Erica Ollmann Saphire
Erica Ollmann Saphire
La Jolla Institute for Immunology
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Tracking changes in SARS-CoV-2 spike: evidence that D614G increases infectivity of the COVID-19 virus
B Korber, WM Fischer, S Gnanakaran, H Yoon, J Theiler, W Abfalterer, ...
Cell 182 (4), 812-827. e19, 2020
Immunological memory to SARS-CoV-2 assessed for up to 8 months after infection
JM Dan, J Mateus, Y Kato, KM Hastie, ED Yu, CE Faliti, A Grifoni, ...
Science 371 (6529), eabf4063, 2021
Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity
CR Moderbacher, SI Ramirez, JM Dan, A Grifoni, KM Hastie, D Weiskopf, ...
Cell 183 (4), 996-1012. e19, 2020
Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design
EO Saphire, PWHI Parren, R Pantophlet, MB Zwick, GM Morris, PM Rudd, ...
science 293 (5532), 1155-1159, 2001
Broadly neutralizing antibodies targeted to the membrane-proximal external region of human immunodeficiency virus type 1 glycoprotein gp41
MB Zwick, AF Labrijn, M Wang, C Spenlehauer, EO Saphire, JM Binley, ...
Journal of virology 75 (22), 10892-10905, 2001
The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of α1→ 2 mannose residues on the outer face of gp120
CN Scanlan, R Pantophlet, MR Wormald, E Ollmann Saphire, R Stanfield, ...
Journal of virology 76 (14), 7306-7321, 2002
Structure of the Ebola virus glycoprotein bound to an antibody from a human survivor
JE Lee, ML Fusco, AJ Hessell, WB Oswald, DR Burton, EO Saphire
Nature 454 (7201), 177-182, 2008
Complement is activated by IgG hexamers assembled at the cell surface
CA Diebolder, FJ Beurskens, RN De Jong, RI Koning, K Strumane, ...
Science 343 (6176), 1260-1263, 2014
Ebola virus VP35 protein binds double-stranded RNA and inhibits alpha/beta interferon production induced by RIG-I signaling
WB Cárdenas, YM Loo, M Gale Jr, AL Hartman, CR Kimberlin, ...
Journal of virology 80 (11), 5168-5178, 2006
gp120: Biologic aspects of structural features
P Poignard, EO Saphire, PWHI Parren, DR Burton
Annual review of immunology 19 (1), 253-274, 2001
Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120
R Pantophlet, E Ollmann Saphire, P Poignard, PWHI Parren, IA Wilson, ...
Journal of virology 77 (1), 642-658, 2003
Ebolavirus glycoprotein structure and mechanism of entry
JE Lee, EO Saphire
Future virology 4 (6), 621-635, 2009
Contrasting IgG structures reveal extreme asymmetry and flexibility
EO Saphire, RL Stanfield, MDM Crispin, PWHI Parren, PM Rudd, ...
Journal of molecular biology 319 (1), 9-18, 2002
Structure of the Lassa virus nucleoprotein reveals a dsRNA-specific 3′ to 5′ exonuclease activity essential for immune suppression
KM Hastie, CR Kimberlin, MA Zandonatti, IJ MacRae, EO Saphire
Proceedings of the National Academy of Sciences 108 (6), 2396-2401, 2011
Structural rearrangement of ebola virus VP40 begets multiple functions in the virus life cycle
ZA Bornholdt, T Noda, DM Abelson, P Halfmann, MR Wood, Y Kawaoka, ...
Cell 154 (4), 763-774, 2013
Sheffield COVID-19 Genomics Group
B Korber, WM Fischer, S Gnanakaran, H Yoon, J Theiler, W Abfalterer, ...
Tracking changes in SARS-CoV-2 spike: evidence that D614G increases …, 2020
Structures of protective antibodies reveal sites of vulnerability on Ebola virus
CD Murin, ML Fusco, ZA Bornholdt, X Qiu, GG Olinger, L Zeitlin, ...
Proceedings of the National Academy of Sciences 111 (48), 17182-17187, 2014
Lassa fever in post-conflict Sierra Leone
JG Shaffer, DS Grant, JS Schieffelin, ML Boisen, A Goba, JN Hartnett, ...
PLoS neglected tropical diseases 8 (3), e2748, 2014
Isolation of potent neutralizing antibodies from a survivor of the 2014 Ebola virus outbreak
ZA Bornholdt, HL Turner, CD Murin, W Li, D Sok, CA Souders, AE Piper, ...
Science 351 (6277), 1078-1083, 2016
Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120
MB Zwick, PWHI Parren, EO Saphire, S Church, M Wang, JK Scott, ...
Journal of virology 77 (10), 5863-5876, 2003
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