Jatin Roper
Jatin Roper
Assistant Professor of Medicine, Duke University
Verified email at duke.edu
Cited by
Cited by
Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH
J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ...
Science 350 (6266), 1391-1396, 2015
High-fat diet enhances stemness and tumorigenicity of intestinal progenitors
S Beyaz, MD Mana, J Roper, D Kedrin, A Saadatpour, SJ Hong, ...
Nature 531 (7592), 53-58, 2016
In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis
J Roper, T Tammela, NM Cetinbas, A Akkad, A Roghanian, S Rickelt, ...
Nature biotechnology 35 (6), 569-576, 2017
The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer
J Roper, MP Richardson, WV Wang, LG Richard, W Chen, EM Coffee, ...
PloS one 6 (9), e25132, 2011
High-fructose corn syrup enhances intestinal tumor growth in mice
MD Goncalves, C Lu, J Tutnauer, TE Hartman, SK Hwang, CJ Murphy, ...
Science 363 (6433), 1345-1349, 2019
The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin
F Francois, J Roper, N Joseph, Z Pei, A Chhada, JR Shak, AZO de Perez, ...
BMC gastroenterology 11 (1), 1-9, 2011
mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1
AC Faber, EM Coffee, C Costa, A Dastur, H Ebi, AN Hata, AT Yeo, ...
Cancer discovery 4 (1), 42-52, 2014
Leptin and Ghrelin in Relation to Helicobacter pylori Status in Adult Males
J Roper, F Francois, PL Shue, MS Mourad, Z Pei, AZ Olivares de Perez, ...
The Journal of Clinical Endocrinology & Metabolism 93 (6), 2350-2357, 2008
WRN helicase is a synthetic lethal target in microsatellite unstable cancers
EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ...
Nature 568 (7753), 551-556, 2019
Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis
R Jackstadt, SR van Hooff, JD Leach, X Cortes-Lavaud, JO Lohuis, ...
Cancer cell 36 (3), 319-336. e7, 2019
The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones
JR Shak, J Roper, GI Perez-Perez, C Tseng, F Francois, Z Gamagaris, ...
Obesity surgery 18 (9), 1089-1096, 2008
The association of gastric leptin with oesophageal inflammation and metaplasia
F Francois, J Roper, AJ Goodman, Z Pei, M Ghumman, M Mourad, ...
Gut 57 (1), 16-24, 2008
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAFV600E colorectal cancer
EM Coffee, AC Faber, J Roper, MJ Sinnamon, G Goel, L Keung, ...
Clinical cancer research 19 (10), 2688-2698, 2013
Helicobacter pylori stimulates gastric epithelial cell MMP-1 secretion via CagA-dependent and-independent ERK activation
MH Pillinger, N Marjanovic, SY Kim, YC Lee, JU Scher, J Roper, ...
Journal of Biological Chemistry 282 (26), 18722-18731, 2007
Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium
N Pentinmikko, S Iqbal, M Mana, S Andersson, AB Cognetta, RM Suciu, ...
Nature 571 (7765), 398-402, 2019
Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated …
GY Koh, A Kane, K Lee, Q Xu, X Wu, J Roper, JB Mason, JW Crott
International journal of cancer 143 (7), 1797-1805, 2018
Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation
J Roper, T Tammela, A Akkad, M Almeqdadi, SB Santos, T Jacks, ...
Nature protocols 13 (2), 217-234, 2018
Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer
J Roper, MJ Sinnamon, EM Coffee, P Belmont, L Keung, ...
Cancer letters 347 (2), 204-211, 2014
Priceless GEMMs: genetically engineered mouse models for colorectal cancer drug development
J Roper, KE Hung
Trends in pharmacological sciences 33 (8), 449-455, 2012
Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis
TRM Lannagan, YK Lee, T Wang, J Roper, ML Bettington, L Fennell, ...
Gut 68 (4), 684-692, 2019
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