| Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH J Yun, E Mullarky, C Lu, KN Bosch, A Kavalier, K Rivera, J Roper, IIC Chio, ... Science 350 (6266), 1391-1396, 2015 | 878 | 2015 |
| High-fat diet enhances stemness and tumorigenicity of intestinal progenitors S Beyaz, MD Mana, J Roper, D Kedrin, A Saadatpour, SJ Hong, ... Nature 531 (7592), 53-58, 2016 | 724 | 2016 |
| In vivo genome editing and organoid transplantation models of colorectal cancer and metastasis J Roper, T Tammela, NM Cetinbas, A Akkad, A Roghanian, S Rickelt, ... Nature biotechnology 35 (6), 569-576, 2017 | 307 | 2017 |
| Epithelial NOTCH signaling rewires the tumor microenvironment of colorectal cancer to drive poor-prognosis subtypes and metastasis R Jackstadt, SR van Hooff, JD Leach, X Cortes-Lavaud, JO Lohuis, ... Cancer cell 36 (3), 319-336. e7, 2019 | 302 | 2019 |
| High-fructose corn syrup enhances intestinal tumor growth in mice MD Goncalves, C Lu, J Tutnauer, TE Hartman, SK Hwang, CJ Murphy, ... Science 363 (6433), 1345-1349, 2019 | 291 | 2019 |
| WRN helicase is a synthetic lethal target in microsatellite unstable cancers EM Chan, T Shibue, JM McFarland, B Gaeta, M Ghandi, N Dumont, ... Nature 568 (7753), 551-556, 2019 | 278 | 2019 |
| Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium N Pentinmikko, S Iqbal, M Mana, S Andersson, AB Cognetta III, RM Suciu, ... Nature 571 (7765), 398-402, 2019 | 195 | 2019 |
| The dual PI3K/mTOR inhibitor NVP-BEZ235 induces tumor regression in a genetically engineered mouse model of PIK3CA wild-type colorectal cancer J Roper, MP Richardson, WV Wang, LG Richard, W Chen, EM Coffee, ... PloS one 6 (9), e25132, 2011 | 166 | 2011 |
| The effect of H. pylori eradication on meal-associated changes in plasma ghrelin and leptin F Francois, J Roper, N Joseph, Z Pei, A Chhada, JR Shak, AZO de Perez, ... BMC gastroenterology 11, 1-9, 2011 | 158 | 2011 |
| Leptin and Ghrelin in Relation to Helicobacter pylori Status in Adult Males J Roper, F Francois, PL Shue, MS Mourad, Z Pei, AZ Olivares de Perez, ... The Journal of Clinical Endocrinology & Metabolism 93 (6), 2350-2357, 2008 | 152 | 2008 |
| Parabacteroides distasonis attenuates toll‐like receptor 4 signaling and Akt activation and blocks colon tumor formation in high‐fat diet‐fed azoxymethane‐treated … GY Koh, A Kane, K Lee, Q Xu, X Wu, J Roper, JB Mason, JW Crott International journal of cancer 143 (7), 1797-1805, 2018 | 141 | 2018 |
| mTOR Inhibition Specifically Sensitizes Colorectal Cancers with KRAS or BRAF Mutations to BCL-2/BCL-XL Inhibition by Suppressing MCL-1 AC Faber, EM Coffee, C Costa, A Dastur, H Ebi, AN Hata, AT Yeo, ... Cancer discovery 4 (1), 42-52, 2014 | 141 | 2014 |
| Regenerative reprogramming of the intestinal stem cell state via hippo signaling suppresses metastatic colorectal cancer P Cheung, J Xiol, MT Dill, WC Yuan, R Panero, J Roper, FG Osorio, ... Cell stem cell 27 (4), 590-604. e9, 2020 | 124 | 2020 |
| The effect of laparoscopic gastric banding surgery on plasma levels of appetite-control, insulinotropic, and digestive hormones JR Shak, J Roper, GI Perez-Perez, C Tseng, F Francois, Z Gamagaris, ... Obesity surgery 18, 1089-1096, 2008 | 110 | 2008 |
| The association of gastric leptin with oesophageal inflammation and metaplasia F Francois, J Roper, AJ Goodman, Z Pei, M Ghumman, M Mourad, ... Gut 57 (1), 16-24, 2008 | 108 | 2008 |
| Gut organoids: mini-tissues in culture to study intestinal physiology and disease M Almeqdadi, MD Mana, J Roper, ÖH Yilmaz American Journal of Physiology-Cell Physiology 317 (3), C405-C419, 2019 | 107 | 2019 |
| Genetic editing of colonic organoids provides a molecularly distinct and orthotopic preclinical model of serrated carcinogenesis TRM Lannagan, YK Lee, T Wang, J Roper, ML Bettington, L Fennell, ... Gut 68 (4), 684-692, 2019 | 105 | 2019 |
| Colonoscopy-based colorectal cancer modeling in mice with CRISPR–Cas9 genome editing and organoid transplantation J Roper, T Tammela, A Akkad, M Almeqdadi, SB Santos, T Jacks, ... Nature protocols 13 (2), 217-234, 2018 | 101 | 2018 |
| Concomitant BRAF and PI3K/mTOR Blockade Is Required for Effective Treatment of BRAFV600E Colorectal Cancer EM Coffee, AC Faber, J Roper, MJ Sinnamon, G Goel, L Keung, ... Clinical cancer research 19 (10), 2688-2698, 2013 | 93 | 2013 |
| Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis S Beyaz, C Chung, H Mou, KE Bauer-Rowe, ME Xifaras, I Ergin, ... Cell stem cell 28 (11), 1922-1935. e5, 2021 | 76 | 2021 |
Omer YilmazMassachusetts Institute of TechnologyVerified email at mit.edu
