Alejandra Bruna
Alejandra Bruna
Associate Scientist
Adresse e-mail validée de cruk.cam.ac.uk
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Dynamics of genomic clones in breast cancer patient xenografts at single-cell resolution
P Eirew, A Steif, J Khattra, G Ha, D Yap, H Farahani, K Gelmon, S Chia, ...
Nature 518 (7539), 422-426, 2015
5392015
Progesterone receptor modulates ERα action in breast cancer
H Mohammed, IA Russell, R Stark, OM Rueda, TE Hickey, GA Tarulli, ...
Nature 523 (7560), 313-317, 2015
5182015
High TGFβ-Smad activity confers poor prognosis in glioma patients and promotes cell proliferation depending on the methylation of the PDGF-B gene
A Bruna, RS Darken, F Rojo, A Ocaña, S Peñuelas, A Arias, R Paris, ...
Cancer cell 11 (2), 147-160, 2007
5032007
Interrogating open issues in cancer precision medicine with patient-derived xenografts
AT Byrne, DG Alférez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ...
Nature Reviews Cancer 17 (4), 254-268, 2017
3982017
Interrogating open issues in cancer precision medicine with patient-derived xenografts
AT Byrne, DG Alférez, F Amant, D Annibali, J Arribas, AV Biankin, A Bruna, ...
Nature Reviews Cancer 17 (4), 254-268, 2017
3982017
A biobank of breast cancer explants with preserved intra-tumor heterogeneity to screen anticancer compounds
A Bruna, OM Rueda, W Greenwood, AS Batra, M Callari, RN Batra, ...
Cell 167 (1), 260-274. e22, 2016
3002016
Maintaining tumor heterogeneity in patient-derived tumor xenografts
JW Cassidy, C Caldas, A Bruna
Cancer research 75 (15), 2963-2968, 2015
2442015
Shieldin complex promotes DNA end-joining and counters homologous recombination in BRCA1-null cells
H Dev, TWW Chiang, C Lescale, I de Krijger, AG Martin, D Pilger, ...
Nature cell biology 20 (8), 954-965, 2018
1692018
RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer
C Cruz, M Castroviejo-Bermejo, S Gutiérrez-Enríquez, A Llop-Guevara, ...
Annals of Oncology 29 (5), 1203-1210, 2018
1522018
Glucocorticoid receptor–JNK interaction mediates inhibition of the JNK pathway by glucocorticoids
A Bruna, M Nicolàs, A Muñoz, JM Kyriakis, C Caelles
The EMBO journal 22 (22), 6035-6044, 2003
1502003
Dynamics of breast-cancer relapse reveal late-recurring ER-positive genomic subgroups
OM Rueda, SJ Sammut, JA Seoane, SF Chin, JL Caswell-Jin, M Callari, ...
Nature 567 (7748), 399-404, 2019
1142019
ZNF703 is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium
DG Holland, A Burleigh, A Git, MA Goldgraben, PA Perez‐Mancera, ...
EMBO molecular medicine 3 (3), 167-180, 2011
1142011
TGFβ induces the formation of tumour-initiating cells in claudin low breast cancer
A Bruna, W Greenwood, J Le Quesne, A Teschendorff, ...
Nature communications 3 (1), 1-12, 2012
982012
A RAD 51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation
M Castroviejo‐Bermejo, C Cruz, A Llop‐Guevara, S Gutiérrez‐Enríquez, ...
EMBO molecular medicine 10 (12), e9172, 2018
862018
PDX-MI: minimal information for patient-derived tumor xenograft models
TF Meehan, N Conte, T Goldstein, G Inghirami, MA Murakami, S Brabetz, ...
Cancer research 77 (21), e62-e66, 2017
682017
MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models
Z Xue, DJ Vis, A Bruna, T Sustic, S van Wageningen, AS Batra, ...
Cell research 28 (7), 719-729, 2018
632018
Clonal decomposition and DNA replication states defined by scaled single-cell genome sequencing
E Laks, A McPherson, H Zahn, D Lai, A Steif, J Brimhall, J Biele, B Wang, ...
Cell 179 (5), 1207-1221. e22, 2019
622019
Neuroprotective action of flavopiridol, a cyclin-dependent kinase inhibitor, in colchicine-induced apoptosis
EG Jorda, E Verdaguer, AM Canudas, A Jiménez, A Bruna, C Caelles, ...
Neuropharmacology 45 (5), 672-683, 2003
562003
ARID1A influences HDAC1/BRD4 activity, intrinsic proliferative capacity and breast cancer treatment response
S Nagarajan, SV Rao, J Sutton, D Cheeseman, S Dunn, EK Papachristou, ...
Nature genetics 52 (2), 187-197, 2020
432020
BRCA 1 and BRCA 2 tumor suppressors protect against endogenous acetaldehyde toxicity
EMC Tacconi, X Lai, C Folio, M Porru, G Zonderland, S Badie, J Michl, ...
EMBO molecular medicine 9 (10), 1398-1414, 2017
392017
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