|Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans|
K Linke, PD Mace, CA Smith, DL Vaux, J Silke, CL Day
Cell death & differentiation 15 (5), 841-848, 2008
|TRAF2 must bind to cellular inhibitors of apoptosis for tumor necrosis factor (TNF) to efficiently activate NF-κB and to prevent TNF-induced apoptosis|
JE Vince, D Pantaki, R Feltham, PD Mace, SM Cordier, AC Schmukle, ...
Journal of Biological Chemistry 284 (51), 35906, 2009
|Structures of the cIAP2 RING domain reveal conformational changes associated with ubiquitin-conjugating enzyme (E2) recruitment|
PD Mace, K Linke, R Feltham, FR Schumacher, CA Smith, DL Vaux, ...
Journal of Biological Chemistry 283 (46), 31633-31640, 2008
|The CARD plays a critical role in ASC foci formation and inflammasome signalling|
M Proell, M Gerlic, PD Mace, JC Reed, SJ Riedl
Biochemical Journal 449 (3), 613-621, 2013
|Smac mimetics activate the E3 ligase activity of cIAP1 protein by promoting RING domain dimerization|
R Feltham, B Bettjeman, R Budhidarmo, PD Mace, S Shirley, SM Condon, ...
Journal of Biological Chemistry 286 (19), 17015-17028, 2011
|Structure of a HOIP/E2~ ubiquitin complex reveals RBR E3 ligase mechanism and regulation|
BC Lechtenberg, A Rajput, R Sanishvili, MK Dobaczewska, CF Ware, ...
Nature 529 (7587), 546-550, 2016
|Assembling the building blocks: structure and function of inhibitor of apoptosis proteins|
PD Mace, S Shirley, CL Day
Cell Death & Differentiation 17 (1), 46-53, 2010
|Structural mechanisms in NLR inflammasome signaling|
BC Lechtenberg, PD Mace, SJ Riedl
Current opinion in structural biology 29, 17-25, 2014
|Molecular mechanism of CCAAT-enhancer binding protein recruitment by the TRIB1 pseudokinase|
JM Murphy, Y Nakatani, SA Jamieson, W Dai, IS Lucet, PD Mace
Structure 23 (11), 2111-2121, 2015
|Molecular cell death platforms and assemblies|
PD Mace, SJ Riedl
Current opinion in cell biology 22 (6), 828-836, 2010
|Live and let die: insights into pseudoenzyme mechanisms from structure|
JM Murphy, PD Mace, PA Eyers
Current opinion in structural biology 47, 95-104, 2017
|Activation and specificity of human caspase-10|
K Wachmann, C Pop, BJ van Raam, M Drag, PD Mace, SJ Snipas, ...
Biochemistry 49 (38), 8307-8315, 2010
|Asymmetric recruitment of cIAPs by TRAF2|
PD Mace, C Smits, DL Vaux, J Silke, CL Day
Journal of molecular biology 400 (1), 8-15, 2010
|Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK|
PD Mace, Y Wallez, MF Egger, MK Dobaczewska, H Robinson, ...
Nature communications 4 (1), 1681, 2013
|High resolution structures of the bone morphogenetic protein type II receptor in two crystal forms: implications for ligand binding|
PD Mace, JF Cutfield, SM Cutfield
Biochemical and biophysical research communications 351 (4), 831-838, 2006
|Identification of highly selective covalent inhibitors by phage display|
S Chen, S Lovell, S Lee, M Fellner, PD Mace, M Bogyo
Nature biotechnology 39 (4), 490-498, 2021
|When worlds collide—mechanisms at the interface between phosphorylation and ubiquitination|
P Filipčík, JR Curry, PD Mace
Journal of molecular biology 429 (8), 1097-1113, 2017
|Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP|
M Vamos, K Welsh, D Finlay, PS Lee, PD Mace, SJ Snipas, ML Gonzalez, ...
ACS chemical biology 8 (4), 725-732, 2013
|Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1|
SA Jamieson, Z Ruan, AE Burgess, JR Curry, HD McMillan, JL Brewster, ...
Science signaling 11 (549), eaau0597, 2018
|Secondary ubiquitin-RING docking enhances Arkadia and Ark2C E3 ligase activity|
JD Wright, PD Mace, CL Day
Nature structural & molecular biology 23 (1), 45-52, 2016