| C-type lectin DC-SIGN modulates Toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-κB SI Gringhuis, J den Dunnen, M Litjens, B van Het Hof, Y van Kooyk, ... Immunity 26 (5), 605-616, 2007 | 744 | 2007 |
| Dectin-1 directs T helper cell differentiation by controlling noncanonical NF-κB activation through Raf-1 and Syk SI Gringhuis, J Den Dunnen, M Litjens, M Van Der Vlist, B Wevers, ... Nature immunology 10 (2), 203-213, 2009 | 595 | 2009 |
| Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori SI Gringhuis, J Den Dunnen, M Litjens, M Van Der Vlist, TBH Geijtenbeek Nature immunology 10 (10), 1081-1088, 2009 | 524 | 2009 |
| HIV-1 exploits innate signaling by TLR8 and DC-SIGN for productive infection of dendritic cells SI Gringhuis, M Van Der Vlist, LM Van Den Berg, J Den Dunnen, M Litjens, ... Nature immunology 11 (5), 419-426, 2010 | 329 | 2010 |
| Afucosylated IgG characterizes enveloped viral responses and correlates with COVID-19 severity MD Larsen, EL de Graaf, ME Sonneveld, HR Plomp, J Nouta, W Hoepel, ... Science 371 (6532), eabc8378, 2021 | 304 | 2021 |
| Innate signaling and regulation of dendritic cell immunity SJ Van Vliet, J den Dunnen, SI Gringhuis, TBH Geijtenbeek, Y van Kooyk Current opinion in immunology 19 (4), 435-440, 2007 | 222 | 2007 |
| High titers and low fucosylation of early human anti–SARS-CoV-2 IgG promote inflammation by alveolar macrophages W Hoepel, HJ Chen, CE Geyer, S Allahverdiyeva, XD Manz, SW de Taeye, ... Science translational medicine 13 (596), eabf8654, 2021 | 221* | 2021 |
| Salp15 binding to DC-SIGN inhibits cytokine expression by impairing both nucleosome remodeling and mRNA stabilization JWR Hovius, MAWP de Jong, J den Dunnen, M Litjens, E Fikrig, ... PLoS pathogens 4 (2), e31, 2008 | 217 | 2008 |
| Innate signaling by the C-type lectin DC-SIGN dictates immune responses J Den Dunnen, SI Gringhuis, TBH Geijtenbeek Cancer Immunology, Immunotherapy 58, 1149-1157, 2009 | 208 | 2009 |
| Control of cytokine production by human fc gamma receptors: implications for pathogen defense and autoimmunity LTC Vogelpoel, DLP Baeten, EC de Jong, J Den Dunnen Frontiers in immunology 6, 79, 2015 | 165 | 2015 |
| Fc gamma receptor-TLR cross-talk elicits pro-inflammatory cytokine production by human M2 macrophages LTC Vogelpoel, IS Hansen, T Rispens, FJM Muller, TMM Van Capel, ... Nature communications 5 (1), 5444, 2014 | 165 | 2014 |
| The mannose cap of mycobacterial lipoarabinomannan does not dominate the Mycobacterium–host interaction BJ Appelmelk, J Den Dunnen, NN Driessen, R Ummels, M Pak, J Nigou, ... Cellular microbiology 10 (4), 930-944, 2008 | 146 | 2008 |
| The inflammatory function of human IgA IS Hansen, DLP Baeten, J den Dunnen Cellular and molecular life sciences 76 (6), 1041-1055, 2019 | 135 | 2019 |
| Pathogen recognition by DC-SIGN shapes adaptive immunity TBH Geijtenbeek, J Den Dunnen, SI Gringhuis Future microbiology 4 (7), 879-890, 2009 | 107 | 2009 |
| IgG opsonization of bacteria promotes Th17 responses via synergy between TLRs and FcγRIIa in human dendritic cells J Den Dunnen, LTC Vogelpoel, T Wypych, FJM Muller, L de Boer, ... Blood, The Journal of the American Society of Hematology 120 (1), 112-121, 2012 | 92 | 2012 |
| Aberrant glycosylation of anti-SARS-CoV-2 spike IgG is a prothrombotic stimulus for platelets AP Bye, W Hoepel, JL Mitchell, S Jégouic, S Loureiro, T Sage, ... Blood, The Journal of the American Society of Hematology 138 (16), 1481-1489, 2021 | 81 | 2021 |
| Serum IgA immune complexes promote proinflammatory cytokine production by human macrophages, monocytes, and Kupffer cells through FcαRI–TLR cross-talk IS Hansen, W Hoepel, SAJ Zaat, DLP Baeten, J den Dunnen The Journal of Immunology 199 (12), 4124-4131, 2017 | 71 | 2017 |
| FcγRIIa cross-talk with TLRs, IL-1R, and IFNγR selectively modulates cytokine production in human myeloid cells LTC Vogelpoel, IS Hansen, MW Visser, SQ Nagelkerke, TW Kuijpers, ... Immunobiology 220 (2), 193-199, 2015 | 67 | 2015 |
| Mice lacking SIGNR1 have stronger T helper 1 responses to Mycobacterium tuberculosis CW Wieland, EA Koppel, J den Dunnen, S Florquin, ANJ McKenzie, ... Microbes and infection 9 (2), 134-141, 2007 | 65 | 2007 |
| FcαRI co-stimulation converts human intestinal CD103+ dendritic cells into pro-inflammatory cells through glycolytic reprogramming IS Hansen, L Krabbendam, JH Bernink, F Loayza-Puch, W Hoepel, ... Nature communications 9 (1), 863, 2018 | 51 | 2018 |
Sonja GringhuisAssociate professor, Amsterdam University Medical CenterVerified email at amsterdamumc.nl
