Insulin signaling, glucose metabolism and mitochondria: major players in Alzheimer's disease and diabetes interrelation SC Correia, RX Santos, C Carvalho, S Cardoso, E Candeias, MS Santos, ... Brain research 1441, 64-78, 2012 | 260 | 2012 |
Crosstalk between diabetes and brain: glucagon-like peptide-1 mimetics as a promising therapy against neurodegeneration AI Duarte, E Candeias, SC Correia, RX Santos, C Carvalho, S Cardoso, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1832 (4), 527-541, 2013 | 183 | 2013 |
The role of endoplasmic reticulum in amyloid precursor protein processing and trafficking: implications for Alzheimer's disease MPI Plácido AI, Pereira CM, Duarte AI, Candeias E, Correia SC, Santos RX ... Biochim Biophys Acta 1842 (9), 1444-53, 2014 | 137* | 2014 |
Insulin as a bridge between type 2 diabetes and Alzheimer disease–how anti-diabetics could be a solution for dementia I Sebastião, E Candeias, MS Santos, CR de Oliveira, PI Moreira, ... Frontiers in endocrinology 5, 2014 | 116 | 2014 |
Gut-brain connection: The neuroprotective effects of the anti-diabetic drug liraglutide EM Candeias, IC Sebastião, SM Cardoso, SC Correia, CI Carvalho, ... World journal of diabetes 6 (6), 807, 2015 | 111 | 2015 |
The impairment of insulin signaling in Alzheimer's disease E Candeias, AI Duarte, C Carvalho, SC Correia, S Cardoso, RX Santos, ... IUBMB life 64 (12), 951-957, 2012 | 108 | 2012 |
Brain GLP-1/IGF-1 signaling and autophagy mediate exendin-4 protection against apoptosis in type 2 diabetic rats E Candeias, I Sebastião, S Cardoso, C Carvalho, MS Santos, CR Oliveira, ... Molecular neurobiology 55, 4030-4050, 2018 | 87 | 2018 |
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates L Piemontese, D Tomás, A Hiremathad, V Capriati, E Candeias, ... Journal of enzyme inhibition and medicinal chemistry 33 (1), 1212-1224, 2018 | 81 | 2018 |
Liraglutide Protects Against Brain Amyloid-β1–42 Accumulation in Female Mice with Early Alzheimer’s Disease-Like Pathology by Partially Rescuing Oxidative … AI Duarte, E Candeias, IN Alves, D Mena, DF Silva, NJ Machado, ... International journal of molecular sciences 21 (5), 1746, 2020 | 66 | 2020 |
Microbial BMAA elicits mitochondrial dysfunction, innate immunity activation, and Alzheimer’s disease features in cortical neurons DF Silva, E Candeias, AR Esteves, JD Magalhães, IL Ferreira, ... Journal of Neuroinflammation 17, 1-18, 2020 | 61 | 2020 |
The role of mitochondrial disturbances in Alzheimer, Parkinson and Huntington diseases C Carvalho, SC Correia, S Cardoso, AI Placido, E Candeias, AI Duarte, ... Expert review of neurotherapeutics 15 (8), 867-884, 2015 | 54 | 2015 |
Hyperglycemia, hypoglycemia and dementia: role of mitochondria and uncoupling proteins MPI Cardoso S, Correia SC, Santos RX, Carvalho C, Candeias E, Duarte AI ... Curr Mol Med 13 (4), 586-601, 2013 | 42 | 2013 |
Footprints of a microbial toxin from the gut microbiome to mesencephalic mitochondria AR Esteves, MF Munoz-Pinto, D Nunes-Costa, E Candeias, DF Silva, ... Gut 72 (1), 73-89, 2023 | 40 | 2023 |
Middle-aged diabetic females and males present distinct susceptibility to Alzheimer disease-like pathology E Candeias, AI Duarte, I Sebastião, MA Fernandes, AI Plácido, ... Molecular Neurobiology 54, 6471-6489, 2017 | 40 | 2017 |
Alzheimer disease as a vascular disorder: Where do mitochondria fit? SC Correia, RX Santos, S Cardoso, C Carvalho, E Candeias, AI Duarte, ... Experimental gerontology 47 (11), 878-886, 2012 | 39 | 2012 |
Perspectives on mitochondrial uncoupling proteins-mediated neuroprotection S Cardoso, S Correia, C Carvalho, E Candeias, AI Plácido, AI Duarte, ... Journal of bioenergetics and biomembranes, 1-13, 2014 | 37 | 2014 |
New multitarget hybrids bearing tacrine and phenylbenzothiazole motifs as potential drug candidates for Alzheimer’s disease R Rajeshwari, K Chand, E Candeias, SM Cardoso, S Chaves, MA Santos Molecules 24 (3), 587, 2019 | 30 | 2019 |
Modulation of endoplasmic reticulum stress: an opportunity to prevent neurodegeneration? AI Placido, C MF Pereira, A I Duarte, E Candeias, S C Correia, ... CNS & Neurological Disorders-Drug Targets (Formerly Current Drug Targets-CNS …, 2015 | 30 | 2015 |
Defective HIF Signaling Pathway and Brain Response to Hypoxia in Neurodegenerative Diseases: Not an “Iffy” Question! S C Correia, C Carvalho, S Cardoso, R X Santos, A I Plácido, E Candeias, ... Current pharmaceutical design 19 (38), 6809-6822, 2013 | 30 | 2013 |
Tacrine–deferiprone hybrids as multi-target-directed metal chelators against Alzheimer's disease: a two-in-one drug K Chand, E Candeias, SM Cardoso, S Chaves, MA Santos Metallomics 10 (10), 1460-1475, 2018 | 28 | 2018 |