Lachlan Whitehead
Lachlan Whitehead
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BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis
K McArthur, LW Whitehead, JM Heddleston, L Li, BS Padman, V Oorschot, ...
Science 359 (6378), eaao6047, 2018
Active MLKL triggers the NLRP3 inflammasome in a cell-intrinsic manner
SA Conos, KW Chen, D De Nardo, H Hara, L Whitehead, G Nez, ...
Proceedings of the National Academy of Sciences 114 (6), E961-E969, 2017
RANK ligand as a potential target for breast cancer prevention in BRCA1-mutation carriers
E Nolan, F Vaillant, D Branstetter, B Pal, G Giner, L Whitehead, SW Lok, ...
Nature medicine 22 (8), 933-939, 2016
Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes
JC Volz, A Yap, X Sisquella, JK Thompson, NTY Lim, LW Whitehead, ...
Cell host & microbe 20 (1), 60-71, 2016
Diffractive imaging using partially coherent x rays
LW Whitehead, GJ Williams, HM Quiney, DJ Vine, RA Dilanian, S Flewett, ...
Physical review letters 103 (24), 243902, 2009
MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis
AL Samson, Y Zhang, ND Geoghegan, XJ Gavin, KA Davies, ...
Nature communications 11 (1), 3151, 2020
Embryogenesis and adult life in the absence of intrinsic apoptosis effectors BAX, BAK, and BOK
FFS Ke, HK Vanyai, AD Cowan, ARD Delbridge, L Whitehead, S Grabow, ...
Cell 173 (5), 1217-1230. e17, 2018
Lensless imaging using broadband X-ray sources
B Abbey, LW Whitehead, HM Quiney, DJ Vine, GA Cadenazzi, ...
Nature Photonics 5 (7), 420-424, 2011
TgCDPK3 Regulates Calcium-Dependent Egress of Toxoplasma gondii from Host Cells
JM McCoy, L Whitehead, GG van Dooren, CJ Tonkin
PLoS Pathogens 8 (12), e1003066, 2012
IL-18 production from the NLRP1 inflammasome prevents obesity and metabolic syndrome
AJ Murphy, MJ Kraakman, HL Kammoun, D Dragoljevic, MKS Lee, ...
Cell metabolism 23 (1), 155-164, 2016
Inhibition of Plasmepsin V activity demonstrates its essential role in protein export, PfEMP1 display, and survival of malaria parasites
BE Sleebs, S Lopaticki, DS Marapana, MT O'Neill, P Rajasekaran, ...
PLoS biology 12 (7), e1001897, 2014
Intraclonal plasticity in mammary tumors revealed through large-scale single-cell resolution 3D imaging
AC Rios, BD Capaldo, F Vaillant, B Pal, R van Ineveld, CA Dawson, ...
Cancer cell 35 (4), 618-632. e6, 2019
The neuropeptide VIP confers anticipatory mucosal immunity by regulating ILC3 activity
C Seillet, K Luong, J Tellier, N Jacquelot, RD Shen, P Hickey, VC Wimmer, ...
Nature immunology 21 (2), 168-177, 2020
SIDT2 transports extracellular dsRNA into the cytoplasm for innate immune recognition
TA Nguyen, BRC Smith, MD Tate, GT Belz, MH Barrios, KD Elgass, ...
Immunity 47 (3), 498-509. e6, 2017
Monosodium urate crystals generate nuclease-resistant neutrophil extracellular traps via a distinct molecular pathway
SM Chatfield, K Grebe, LW Whitehead, KL Rogers, T Nebl, JM Murphy, ...
The Journal of Immunology 200 (5), 1802-1816, 2018
Essential role for a novel population of binucleated mammary epithelial cells in lactation
AC Rios, NY Fu, PR Jamieson, B Pal, L Whitehead, KR Nicholas, ...
Nature communications 7 (1), 11400, 2016
A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo
KS Potts, TJ Sargeant, JF Markham, W Shi, C Biben, EC Josefsson, ...
Blood, The Journal of the American Society of Hematology 124 (17), 2725-2729, 2014
Plasmodium falciparum ligand binding to erythrocytes induce alterations in deformability essential for invasion
X Sisquella, T Nebl, JK Thompson, L Whitehead, BM Malpede, ...
Elife 6, e21083, 2017
Inhibition of hematopoietic cell kinase activity suppresses myeloid cell-mediated colon cancer progression
AR Poh, CG Love, F Masson, A Preaudet, C Tsui, L Whitehead, S Monard, ...
Cancer Cell 31 (4), 563-575. e5, 2017
Protein O-fucosylation in Plasmodium falciparum ensures efficient infection of mosquito and vertebrate hosts
S Lopaticki, ASP Yang, A John, NE Scott, JP Lingford, MT O’Neill, ...
Nature communications 8 (1), 561, 2017
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