John Creemers
John Creemers
Professor of biochemical neuroendocrinology, KU Leuven
Verified email at - Homepage
Cited by
Cited by
Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
RS Jackson, JWM Creemers, S Ohagi, ML Raffin-Sanson, L Sanders, ...
Nature genetics 16 (3), 303-306, 1997
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
D Scheuner, D Vander Mierde, B Song, D Flamez, JWM Creemers, ...
Nature medicine 11 (7), 757-764, 2005
Small-intestinal dysfunction accompanies the complex endocrinopathy of human proprotein convertase 1 deficiency
RS Jackson, JWM Creemers, IS Farooqi, ML Raffin-Sanson, A Varro, ...
The Journal of clinical investigation 112 (10), 1550-1560, 2003
A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular …
BG Challis, LE Pritchard, JWM Creemers, J Delplanque, JM Keogh, ...
Human molecular genetics 11 (17), 1997-2004, 2002
Common nonsynonymous variants in PCSK1 confer risk of obesity
M Benzinou, JWM Creemers, H Choquet, S Lobbens, C Dina, E Durand, ...
Nature genetics 40 (8), 943-945, 2008
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice
K Lemaire, MA Ravier, A Schraenen, JWM Creemers, R Van de Plas, ...
Proceedings of the National Academy of Sciences 106 (35), 14872-14877, 2009
Curbing activation: proprotein convertases in homeostasis and pathology
NA Taylor, WJM Van De Ven, JWM Creemers
The FASEB journal 17 (10), 1215-1227, 2003
Processing of β-secretase by furin and other members of the proprotein convertase family
JWM Creemers, DI Dominguez, E Plets, L Serneels, NA Taylor, ...
Journal of Biological Chemistry 276 (6), 4211-4217, 2001
Hyperphagia and early-onset obesity due to a novel homozygous missense mutation in prohormone convertase 1/3
IS Farooqi, K Volders, R Stanhope, R Heuschkel, A White, E Lank, ...
The Journal of Clinical Endocrinology & Metabolism 92 (9), 3369-3373, 2007
T-cell-expressed proprotein convertase furin is essential for maintenance of peripheral immune tolerance
M Pesu, WT Watford, L Wei, L Xu, I Fuss, W Strober, J Andersson, ...
Nature 455 (7210), 246-250, 2008
Processing by proprotein convertases is required for glypican-3 modulation of cell survival, Wnt signaling, and gastrulation movements
B De Cat, SY Muyldermans, C Coomans, G Degeest, B Vanderschueren, ...
The Journal of cell biology 163 (3), 625-635, 2003
Constitutive α‐secretase cleavage of the β‐amyloid precursor protein in the furin‐deficient LoVo cell line: involvement of the pro‐hormone convertase 7 and the disintegrin …
E Lopez‐Perez, Y Zhang, SJ Frank, J Creemers, N Seidah, F Checler
Journal of neurochemistry 76 (5), 1532-1539, 2001
Modulation of furin-mediated proprotein processing activity by site-directed mutagenesis.
JW Creemers, RJ Siezen, AJ Roebroek, TA Ayoubi, D Huylebroeck, ...
Journal of Biological Chemistry 268 (29), 21826-21834, 1993
Proteolytic maturation and activation of autotaxin (NPP2), a secreted metastasis-enhancing lysophospholipase D
S Jansen, C Stefan, JWM Creemers, E Waelkens, A Van Eynde, ...
Journal of cell science 118 (14), 3081-3089, 2005
In vivo evidence that furin from hepatocytes inactivates PCSK9
R Essalmani, D Susan-Resiga, A Chamberland, M Abifadel, ...
Journal of Biological Chemistry 286 (6), 4257-4263, 2011
Limited redundancy of the proprotein convertase furin in mouse liver
AJM Roebroek, NA Taylor, E Louagie, I Pauli, L Smeijers, A Snellinx, ...
Journal of Biological Chemistry 279 (51), 53442-53450, 2004
Impaired islet function in commonly used transgenic mouse lines due to human growth hormone minigene expression
B Brouwers, G de Faudeur, AB Osipovich, L Goyvaerts, K Lemaire, ...
Cell metabolism 20 (6), 979-990, 2014
Endoproteolytic Cleavage of Its Propeptide Is a Prerequisite for Efficient Transport of Furin Out of the Endoplasmic Reticulum (∗)
JWM Creemers, M Vey, W Schäfer, TAY Ayoubi, AJM Roebroek, ...
Journal of Biological Chemistry 270 (6), 2695-2702, 1995
Agouti-related protein is posttranslationally cleaved by proprotein convertase 1 to generate agouti-related protein (AGRP) 83–132: interaction between AGRP83–132 and …
JWM Creemers, LE Pritchard, A Gyte, P Le Rouzic, S Meulemans, ...
Endocrinology 147 (4), 1621-1631, 2006
Regulation of the expression of GARP/latent TGF-β1 complexes on mouse T cells and their role in regulatory T cell and Th17 differentiation
JP Edwards, H Fujii, AX Zhou, J Creemers, D Unutmaz, EM Shevach
The Journal of Immunology 190 (11), 5506-5515, 2013
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