| RING-type E3 ligases: master manipulators of E2 ubiquitin-conjugating enzymes and ubiquitination MB Metzger, JN Pruneda, RE Klevit, AM Weissman Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1843 (1), 47-60, 2014 | 679 | 2014 |
| Structure of an E3: E2∼ Ub complex reveals an allosteric mechanism shared among RING/U-box ligases JN Pruneda, PJ Littlefield, SE Soss, KA Nordquist, WJ Chazin, PS Brzovic, ... Molecular cell 47 (6), 933-942, 2012 | 339 | 2012 |
| Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis T Wauer, KN Swatek, JL Wagstaff, C Gladkova, JN Pruneda, MA Michel, ... The EMBO journal 34 (3), 307-325, 2015 | 325 | 2015 |
| Assembly and Specific Recognition of K29-and K33-Linked Polyubiquitin MA Michel, PR Elliott, KN Swatek, M Simicek, JN Pruneda, JL Wagstaff, ... Molecular cell 58 (1), 95-109, 2015 | 218 | 2015 |
| Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis LM Starita, JN Pruneda, RS Lo, DM Fowler, HJ Kim, JB Hiatt, J Shendure, ... Proceedings of the National Academy of Sciences 110 (14), E1263-E1272, 2013 | 211 | 2013 |
| OTUB1 co-opts Lys48-linked ubiquitin recognition to suppress E2 enzyme function YC Juang, MC Landry, M Sanches, V Vittal, CCY Leung, DF Ceccarelli, ... Molecular cell 45 (3), 384-397, 2012 | 207 | 2012 |
| Allosteric activation of the RNF146 ubiquitin ligase by a poly (ADP-ribosyl) ation signal PA DaRosa, Z Wang, X Jiang, JN Pruneda, F Cong, RE Klevit, W Xu Nature 517 (7533), 223-226, 2015 | 204 | 2015 |
| Insights into ubiquitin chain architecture using Ub-clipping KN Swatek, JL Usher, AF Kueck, C Gladkova, TET Mevissen, JN Pruneda, ... Nature 572 (7770), 533-537, 2019 | 178 | 2019 |
| Ubiquitin in motion: Structural studies of the ubiquitin-conjugating enzyme∼ ubiquitin conjugate JN Pruneda, KE Stoll, LJ Bolton, PS Brzovic, RE Klevit Biochemistry 50 (10), 1624-1633, 2011 | 158 | 2011 |
| A cascading activity-based probe sequentially targets E1-E2-E3 ubiquitin enzymes MPC Mulder, K Witting, I Berlin, JN Pruneda, KP Wu, JG Chang, R Merkx, ... Nature chemical biology 12 (7), 523-530, 2016 | 142 | 2016 |
| The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases JN Pruneda, CH Durkin, PP Geurink, H Ovaa, B Santhanam, DW Holden, ... Molecular Cell 63 (2), 261-276, 2016 | 137 | 2016 |
| Structural and functional studies on the interaction of GspC and GspD in the type II secretion system KV Korotkov, TL Johnson, MG Jobling, J Pruneda, E Pardon, A Héroux, ... PLoS pathogens 7 (9), e1002228, 2011 | 110 | 2011 |
| Structural Insights into the Conformation and Oligomerization of E2∼ Ubiquitin Conjugates RC Page, JN Pruneda, J Amick, RE Klevit, S Misra Biochemistry 51 (20), 4175-4187, 2012 | 92 | 2012 |
| E2~ Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis JN Pruneda, FD Smith, A Daurie, DL Swaney, J Villén, JD Scott, ... The EMBO journal 33 (5), 437-449, 2014 | 70 | 2014 |
| Irreversible inactivation of ISG15 by a viral leader protease enables alternative infection detection strategies KN Swatek, M Aumayr, JN Pruneda, LJ Visser, S Berryman, AF Kueck, ... Proceedings of the National Academy of Sciences 115 (10), 2371-2376, 2018 | 69 | 2018 |
| An invisible ubiquitin conformation is required for efficient phosphorylation by PINK1 C Gladkova, AF Schubert, JL Wagstaff, JN Pruneda, SMV Freund, ... The EMBO Journal 36 (24), 3555-3572, 2017 | 55 | 2017 |
| Development of Diubiquitin‐Based FRET Probes To Quantify Ubiquitin Linkage Specificity of Deubiquitinating Enzymes PP Geurink, BDM van Tol, D van Dalen, PJG Brundel, TET Mevissen, ... ChemBioChem 17 (9), 816-820, 2016 | 52 | 2016 |
| Identification and characterization of diverse OTU deubiquitinases in bacteria AF Schubert, JV Nguyen, TG Franklin, PP Geurink, CG Roberts, ... The EMBO journal 39 (15), e105127, 2020 | 50 | 2020 |
| A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation JN Pruneda, RJ Bastidas, E Bertsoulaki, KN Swatek, B Santhanam, ... Nature microbiology 3 (12), 1377-1384, 2018 | 50 | 2018 |
| The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence GJ Grabe, Y Zhang, M Przydacz, N Rolhion, Y Yang, JN Pruneda, ... Journal of Biological Chemistry 291 (50), 25853-25863, 2016 | 47 | 2016 |
