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| Histone recognition and large-scale structural analysis of the human bromodomain family P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ... Cell 149 (1), 214-231, 2012 | 1334 | 2012 |
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| The promise and peril of chemical probes CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ... Nature chemical biology 11 (8), 536-541, 2015 | 651 | 2015 |
| Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty, ... Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006 | 651 | 2006 |
| A suite of triple resonance NMR experiments for the backbone assignment of 15N, 13C, 2H labeled proteins with high sensitivity T Yamazaki, W Lee, CH Arrowsmith, DR Muhandiram, LE Kay Journal of the American Chemical Society 116 (26), 11655-11666, 1994 | 634 | 1994 |
| Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ... Blood, The Journal of the American Society of Hematology 117 (8), 2451-2459, 2011 | 601 | 2011 |
| ATM‐dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post‐translational activation of p53 protein involving poly (ADP‐ribose) polymerase H Vaziri, MD West, RC Allsopp, TS Davison, YS Wu, CH Arrowsmith, ... The EMBO journal 16 (19), 6018-6033, 1997 | 497 | 1997 |
| Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell–and patient-derived tumor organoids L Huang, A Holtzinger, I Jagan, M BeGora, I Lohse, N Ngai, C Nostro, ... Nature medicine 21 (11), 1364-1371, 2015 | 491 | 2015 |
| A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ... Nature chemical biology 7 (8), 566-574, 2011 | 480 | 2011 |
| Self-renewal as a therapeutic target in human colorectal cancer A Kreso, P Van Galen, NM Pedley, E Lima-Fernandes, C Frelin, T Davis, ... Nature medicine 20 (1), 29-36, 2014 | 469 | 2014 |
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| Structural proteomics of an archaeon D Christendat, A Yee, A Dharamsi, Y Kluger, A Savchenko, JR Cort, ... Nature structural biology 7 (10), 903-909, 2000 | 407 | 2000 |
| An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1 KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ... ACS chemical biology 8 (6), 1324-1334, 2013 | 404 | 2013 |
| Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1: implications for EBV-mediated immortalization V Saridakis, Y Sheng, F Sarkari, MN Holowaty, K Shire, T Nguyen, ... Molecular cell 18 (1), 25-36, 2005 | 393 | 2005 |
| Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth J Zhu, MA Sammons, G Donahue, Z Dou, M Vedadi, M Getlik, ... Nature 525 (7568), 206-211, 2015 | 391 | 2015 |
| Latent and active p53 are identical in conformation A Ayed, FAA Mulder, GS Yi, Y Lu, LE Kay, CH Arrowsmith Nature structural biology 8 (9), 756-760, 2001 | 333 | 2001 |
| Solution structure of the tetrameric minimum transforming domain of p53 W Lee, TS Harvey, Y Yin, P Yau, D Litchfield, CH Arrowsmith Nature structural biology 1 (12), 877-890, 1994 | 332 | 1994 |
| Placental transforming growth factor-β is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression PX Li, J Wong, A Ayed, D Ngo, AM Brade, C Arrowsmith, RC Austin, ... Journal of Biological Chemistry 275 (26), 20127-20135, 2000 | 330 | 2000 |
