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Seng H. Cheng
Seng H. Cheng
Alexion, AstraZeneca Rare Disease
Geverifieerd e-mailadres voor alexion.com
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Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis
SH Cheng, RJ Gregory, J Marshall, S Paul, DW Souza, GA White, ...
Cell 63 (4), 827-834, 1990
21601990
Sustained therapeutic reversal of Huntington's disease by transient repression of huntingtin synthesis
HB Kordasiewicz, LM Stanek, EV Wancewicz, C Mazur, MM McAlonis, ...
Neuron 74 (6), 1031-1044, 2012
8322012
Expression of cystic fibrosis transmembrane conductance regulator corrects defective chloride channel regulation in cystic fibrosis airway epithelial cells
DP Rich, MP Anderson, RJ Gregory, SH Cheng, S Paul, DM Jefferson, ...
Nature 347 (6291), 358-363, 1990
8181990
Phosphorylation of the R domain by cAMP-dependent protein kinase regulates the CFTR chloride channel
SH Cheng, DP Rich, J Marshall, RJ Gregory, MJ Welsh, AE Smith
Cell 66 (5), 1027-1036, 1991
8011991
Nomenclature for synthetic gene delivery systems
PL Felgner, Y Barenholz, JP Behr, SH Cheng, P Cullis, L Huang, ...
Human gene therapy 8 (5), 511-512, 1997
6491997
Detailed analysis of structures and formulations of cationic lipids for efficient gene transfer to the lung
ER Lee, J Marshall, CS Siegel, C Jiang, NS Yew, MR Nichols, ...
Human gene therapy 7 (14), 1701-1717, 1996
6201996
Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src
H Piwnica-Worms, KB Saunders, TM Roberts, AE Smith, SH Cheng
Cell 49 (1), 75-82, 1987
6131987
Cationic lipid-mediated CFTR gene transfer to the lungs and nose of patients with cystic fibrosis: a double-blind placebo-controlled trial
E Alton, M Stern, R Farley, A Jaffe, SL Chadwick, J Phillips, J Davies, ...
The Lancet 353 (9157), 947-954, 1999
5631999
Antisense oligonucleotides delivered to the mouse CNS ameliorate symptoms of severe spinal muscular atrophy
MA Passini, J Bu, AM Richards, C Kinnecom, SP Sardi, LM Stanek, Y Hua, ...
Science translational medicine 3 (72), 72ra18-72ra18, 2011
5602011
Targeting nuclear RNA for in vivo correction of myotonic dystrophy
TM Wheeler, AJ Leger, SK Pandey, AR MacLeod, M Nakamori, SH Cheng, ...
Nature 488 (7409), 111-115, 2012
5212012
Repeated nebulisation of non-viral CFTR gene therapy in patients with cystic fibrosis: a randomised, double-blind, placebo-controlled, phase 2b trial
EWFW Alton, DK Armstrong, D Ashby, KJ Bayfield, D Bilton, ...
The Lancet Respiratory Medicine 3 (9), 684-691, 2015
5032015
Expression and characterization of the cystic fibrosis transmembrane conductance regulator
RJ Gregory, SH Cheng, DP Rich, J Marshall, S Paul, K Hehir, ...
Nature 347 (6291), 382-386, 1990
4701990
Hypoxia-inducible factor-1 mediates activation of cultured vascular endothelial cells by inducing multiple angiogenic factors
M Yamakawa, LX Liu, T Date, AJ Belanger, KA Vincent, GY Akita, ...
Circulation research 93 (7), 664-673, 2003
4622003
A novel cationic lipid greatly enhances plasmid DNA delivery and expression in mouse lung.
CJ Wheeler, PL Felgner, YJ Tsai, J Marshall, L Sukhu, SG Doh, J Hartikka, ...
Proceedings of the National Academy of Sciences 93 (21), 11454-11459, 1996
4001996
CpG-free plasmids confer reduced inflammation and sustained pulmonary gene expression
SC Hyde, IA Pringle, S Abdullah, AE Lawton, LA Davies, A Varathalingam, ...
Nature biotechnology 26 (5), 549-551, 2008
3712008
Acid β‐glucosidase mutants linked to Gaucher disease, Parkinson disease, and Lewy body dementia alter α‐synuclein processing
V Cullen, SP Sardi, J Ng, YH Xu, Y Sun, JJ Tomlinson, P Kolodziej, I Kahn, ...
Annals of neurology 69 (6), 940-953, 2011
3542011
Improved cationic lipid formulations for in vivo gene therapy.
PL Felgner, YJ Tsai, L Sukhu, CJ Wheeler, M Manthorpe, J Marshall, ...
Annals of the New York Academy of Sciences 772, 126-139, 1995
3541995
Biophysical characterization of cationic lipid: DNA complexes
SJ Eastman, C Siegel, J Tousignant, AE Smith, SH Cheng, RK Scheule
Biochimica et Biophysica Acta (BBA)-Biomembranes 1325 (1), 41-62, 1997
3491997
CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy
MA Passini, J Bu, EM Roskelley, AM Richards, SP Sardi, CR O’Riordan, ...
The Journal of clinical investigation 120 (4), 1253-1264, 2010
3442010
CNS expression of glucocerebrosidase corrects α-synuclein pathology and memory in a mouse model of Gaucher-related synucleinopathy
SP Sardi, J Clarke, C Kinnecom, TJ Tamsett, L Li, LM Stanek, MA Passini, ...
Proceedings of the National Academy of Sciences 108 (29), 12101-12106, 2011
3392011
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Artikelen 1–20