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Michael DiGruccio
Michael DiGruccio
M6P Therapeutics
Verified email at m6ptherapeutics.com
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Year
Comprehensive alpha, beta and delta cell transcriptomes reveal that ghrelin selectively activates delta cells and promotes somatostatin release from pancreatic islets
MR DiGruccio, AM Mawla, CJ Donaldson, GM Noguchi, J Vaughan, ...
Molecular metabolism 5 (7), 449-458, 2016
3242016
NMR structure and peptide hormone binding site of the first extracellular domain of a type B1 G protein-coupled receptor
CRR Grace, MH Perrin, MR DiGruccio, CL Miller, JE Rivier, WW Vale, ...
Proceedings of the National Academy of Sciences 101 (35), 12836-12841, 2004
2492004
Virgin beta cells persist throughout life at a neogenic niche within pancreatic islets
T van der Meulen, AM Mawla, MR DiGruccio, MW Adams, V Nies, ...
Cell metabolism 25 (4), 911-926. e6, 2017
2092017
Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists
J Rivier, J Gulyas, D Kirby, W Low, MH Perrin, K Kunitake, M DiGruccio, ...
Journal of medicinal chemistry 45 (21), 4737-4747, 2002
1902002
The abolishment of anesthesia-induced cognitive impairment by timely protection of mitochondria in the developing rat brain: the importance of free oxygen radicals and …
A Boscolo, JA Starr, V Sanchez, N Lunardi, MR DiGruccio, C Ori, A Erisir, ...
Neurobiology of disease 45 (3), 1031-1041, 2012
1792012
Structure of the N-terminal domain of a type B1 G protein-coupled receptor in complex with a peptide ligand
CRR Grace, MH Perrin, J Gulyas, MR DiGruccio, JP Cantle, JE Rivier, ...
Proceedings of the National Academy of Sciences 104 (12), 4858-4863, 2007
1602007
A soluble mouse brain splice variant of type 2α corticotropin-releasing factor (CRF) receptor binds ligands and modulates their activity
AM Chen, MH Perrin, MR DiGruccio, JM Vaughan, BK Brar, CM Arias, ...
Proceedings of the National Academy of Sciences 102 (7), 2620-2625, 2005
1332005
Reversal of Neuropathic Pain in Diabetes by Targeting Glycosylation of Cav3.2 T-Type Calcium Channels
P Orestes, HP Osuru, WE McIntire, MO Jacus, R Salajegheh, MM Jagodic, ...
Diabetes 62 (11), 3828-3838, 2013
1202013
General anesthesia causes epigenetic histone modulation of c-Fos and brain-derived neurotrophic factor, target genes important for neuronal development in the immature rat …
L Dalla Massara, HP Osuru, A Oklopcic, D Milanovic, SM Joksimovic, ...
Anesthesiology 124 (6), 1311-1327, 2016
792016
A soluble form of the first extracellular domain of mouse type 2β corticotropin-releasing factor receptor reveals differential ligand specificity
MH Perrin, MR DiGruccio, SC Koerber, JE Rivier, KS Kunitake, DL Bain, ...
Journal of Biological Chemistry 278 (18), 15595-15600, 2003
752003
Primary cilia control glucose homeostasis via islet paracrine interactions
JW Hughes, JH Cho, HE Conway, MR DiGruccio, XW Ng, HF Roseman, ...
Proceedings of the National Academy of Sciences 117 (16), 8912-8923, 2020
642020
Stressin1-A, a Potent Corticotropin Releasing Factor Receptor 1 (CRF1)-Selective Peptide Agonist
J Rivier, J Gulyas, K Kunitake, M DiGruccio, JP Cantle, MH Perrin, ...
Journal of medicinal chemistry 50 (7), 1668-1674, 2007
532007
Type 2 corticotropin-releasing factor receptor in the ventromedial nucleus of hypothalamus is critical in regulating feeding and lipid metabolism in white adipose tissue
H Chao, M Digruccio, P Chen, C Li
Endocrinology 153 (1), 166-176, 2012
502012
Free radical signalling underlies inhibition of CaV3.2 T‐type calcium channels by nitrous oxide in the pain pathway
P Orestes, D Bojadzic, JH Lee, E Leach, R Salajegheh, MR DiGruccio, ...
The Journal of physiology 589 (1), 135-148, 2011
482011
Inhibition of T-type calcium current in rat thalamocortical neurons by isoflurane
VS Eckle, MR DiGruccio, VN Uebele, JJ Renger, SM Todorovic
Neuropharmacology 63 (2), 266-273, 2012
392012
Hyperexcitability of rat thalamocortical networks after exposure to general anesthesia during brain development
MR DiGruccio, S Joksimovic, PM Joksovic, N Lunardi, R Salajegheh, ...
Journal of Neuroscience 35 (4), 1481-1492, 2015
372015
The role of T‐type calcium channels in the subiculum: to burst or not to burst?
SM Joksimovic, P Eggan, Y Izumi, SL Joksimovic, V Tesic, RM Dietz, ...
The Journal of physiology 595 (19), 6327-6348, 2017
322017
Inhibition of CaV3. 2 T-type calcium channels in peripheral sensory neurons contributes to analgesic properties of epipregnanolone
C Ayoola, SM Hwang, SJ Hong, KE Rose, C Boyd, N Bozic, JY Park, ...
Psychopharmacology 231, 3503-3515, 2014
262014
Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled …
MH Perrin, CRR Grace, MR DiGruccio, WH Fischer, SK Maji, JP Cantle, ...
Journal of biological chemistry 282 (52), 37529-37536, 2007
212007
MALDI-MS analysis of peptides modified with photolabile arylazido groups
W Low, J Kang, M DiGruccio, D Kirby, M Perrin, WH Fischer
Journal of the American Society for Mass Spectrometry 15 (8), 1156-1160, 2004
192004
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