| Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease CC Bell, DFG Hendriks, SML Moro, E Ellis, J Walsh, A Renblom, ... Scientific reports 6 (1), 25187, 2016 | 556 | 2016 |
| Novel 3D culture systems for studies of human liver function and assessments of the hepatotoxicity of drugs and drug candidates VM Lauschke, DFG Hendriks, CC Bell, TB Andersson, ... Chemical research in toxicology 29 (12), 1936-1955, 2016 | 218 | 2016 |
| Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing B Artegiani, D Hendriks, J Beumer, R Kok, X Zheng, I Joore, ... Nature cell biology 22 (3), 321-331, 2020 | 146 | 2020 |
| Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability DFG Hendriks, L Fredriksson Puigvert, S Messner, W Mortiz, ... Scientific reports 6 (1), 1-12, 2016 | 134 | 2016 |
| High-resolution mRNA and secretome atlas of human enteroendocrine cells J Beumer, J Puschhof, J Bauzá-Martinez, A Martínez-Silgado, ... Cell 181 (6), 1291-1306. e19, 2020 | 103 | 2020 |
| Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation VM Lauschke, SU Vorrink, SML Moro, F Rezayee, Å Nordling, ... Hepatology 64 (5), 1743-1756, 2016 | 102 | 2016 |
| Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids A Marsee, FJM Roos, MMA Verstegen, F Roos, M Verstegen, H Clevers, ... Cell Stem Cell 28 (5), 816-832, 2021 | 97 | 2021 |
| 3D primary hepatocyte culture systems for analyses of liver diseases, drug metabolism, and toxicity: emerging culture paradigms and applications VM Lauschke, RZ Shafagh, DFG Hendriks, M Ingelman‐Sundberg Biotechnology journal 14 (7), 1800347, 2019 | 97 | 2019 |
| Three-dimensional spheroid primary human hepatocytes in monoculture and coculture with nonparenchymal cells A Baze, C Parmentier, DFG Hendriks, T Hurrell, B Heyd, P Bachellier, ... Tissue Engineering Part C: Methods 24 (9), 534-545, 2018 | 76 | 2018 |
| CRISPR-Cas tools and their application in genetic engineering of human stem cells and organoids D Hendriks, H Clevers, B Artegiani Cell Stem Cell 27 (5), 705-731, 2020 | 74 | 2020 |
| Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver D Hendriks, B Artegiani, H Hu, S Chuva de Sousa Lopes, H Clevers Nature Protocols 16 (1), 182-217, 2021 | 48 | 2021 |
| New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment A Punt, H Bouwmeester, BJ Blaauboer, S Coecke, B Hakkert, ... ALTEX: Alternatives to Animal Experimentation 37 (4), 607-622, 2020 | 45 | 2020 |
| Human liver spheroids as a model to study aetiology and treatment of hepatic fibrosis T Hurrell, V Kastrinou-Lampou, A Fardellas, DFG Hendriks, Å Nordling, ... Cells 9 (4), 964, 2020 | 38 | 2020 |
| Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms CS Pridgeon, C Schlott, MW Wong, MB Heringa, T Heckel, J Leedale, ... Archives of toxicology 92, 557-569, 2018 | 38 | 2018 |
| Human NAD (P) H: quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid G Vredenburg, NS Elias, H Venkataraman, DFG Hendriks, ... Chemical research in toxicology 27 (4), 576-586, 2014 | 36 | 2014 |
| Expression and function of mARC: roles in lipogenesis and metabolic activation of ximelagatran EPA Neve, H Köfeler, DFG Hendriks, Å Nordling, V Gogvadze, ... PLoS One 10 (9), e0138487, 2015 | 29 | 2015 |
| Clinically relevant cytochrome P450 3A4 induction mechanisms and drug screening in three‐dimensional spheroid cultures of primary human hepatocytes DFG Hendriks, SU Vorrink, T Smutny, SC Sim, Å Nordling, S Ullah, ... Clinical Pharmacology & Therapeutics 108 (4), 844-855, 2020 | 26 | 2020 |
| Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent C Parmentier, DFG Hendriks, B Heyd, P Bachellier, ... Toxicology letters 295, 187-194, 2018 | 19 | 2018 |
| Mechanisms of chronic fialuridine hepatotoxicity as revealed in primary human hepatocyte spheroids DFG Hendriks, T Hurrell, J Riede, M van der Horst, S Tuovinen, ... Toxicological Sciences 171 (2), 385-395, 2019 | 16 | 2019 |
| In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed F Bonanini, D Kurek, S Previdi, A Nicolas, D Hendriks, S de Ruiter, ... Angiogenesis 25 (4), 455-470, 2022 | 9 | 2022 |
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