|Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease|
CC Bell, DFG Hendriks, SML Moro, E Ellis, J Walsh, A Renblom, ...
Scientific reports 6 (1), 25187, 2016
|Novel 3D culture systems for studies of human liver function and assessments of the hepatotoxicity of drugs and drug candidates|
VM Lauschke, DFG Hendriks, CC Bell, TB Andersson, ...
Chemical research in toxicology 29 (12), 1936-1955, 2016
|Fast and efficient generation of knock-in human organoids using homology-independent CRISPR–Cas9 precision genome editing|
B Artegiani, D Hendriks, J Beumer, R Kok, X Zheng, I Joore, ...
Nature cell biology 22 (3), 321-331, 2020
|Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability|
DFG Hendriks, L Fredriksson Puigvert, S Messner, W Mortiz, ...
Scientific reports 6 (1), 1-12, 2016
|High-resolution mRNA and secretome atlas of human enteroendocrine cells|
J Beumer, J Puschhof, J Bauzß-Martinez, A MartÝnez-Silgado, ...
Cell 181 (6), 1291-1306. e19, 2020
|Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation|
VM Lauschke, SU Vorrink, SML Moro, F Rezayee, ┼ Nordling, ...
Hepatology 64 (5), 1743-1756, 2016
|Building consensus on definition and nomenclature of hepatic, pancreatic, and biliary organoids|
A Marsee, FJM Roos, MMA Verstegen, F Roos, M Verstegen, H Clevers, ...
Cell Stem Cell 28 (5), 816-832, 2021
|3D primary hepatocyte culture systems for analyses of liver diseases, drug metabolism, and toxicity: emerging culture paradigms and applications|
VM Lauschke, RZ Shafagh, DFG Hendriks, M Ingelman‐Sundberg
Biotechnology journal 14 (7), 1800347, 2019
|Three-dimensional spheroid primary human hepatocytes in monoculture and coculture with nonparenchymal cells|
A Baze, C Parmentier, DFG Hendriks, T Hurrell, B Heyd, P Bachellier, ...
Tissue Engineering Part C: Methods 24 (9), 534-545, 2018
|CRISPR-Cas tools and their application in genetic engineering of human stem cells and organoids|
D Hendriks, H Clevers, B Artegiani
Cell Stem Cell 27 (5), 705-731, 2020
|Establishment of human fetal hepatocyte organoids and CRISPR–Cas9-based gene knockin and knockout in organoid cultures from human liver|
D Hendriks, B Artegiani, H Hu, S Chuva de Sousa Lopes, H Clevers
Nature Protocols 16 (1), 182-217, 2021
|New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment|
A Punt, H Bouwmeester, BJ Blaauboer, S Coecke, B Hakkert, ...
ALTEX: Alternatives to Animal Experimentation 37 (4), 607-622, 2020
|Human liver spheroids as a model to study aetiology and treatment of hepatic fibrosis|
T Hurrell, V Kastrinou-Lampou, A Fardellas, DFG Hendriks, ┼ Nordling, ...
Cells 9 (4), 964, 2020
|Innovative organotypic in vitro models for safety assessment: aligning with regulatory requirements and understanding models of the heart, skin, and liver as paradigms|
CS Pridgeon, C Schlott, MW Wong, MB Heringa, T Heckel, J Leedale, ...
Archives of toxicology 92, 557-569, 2018
|Human NAD (P) H: quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid|
G Vredenburg, NS Elias, H Venkataraman, DFG Hendriks, ...
Chemical research in toxicology 27 (4), 576-586, 2014
|Expression and function of mARC: roles in lipogenesis and metabolic activation of ximelagatran|
EPA Neve, H K÷feler, DFG Hendriks, ┼ Nordling, V Gogvadze, ...
PLoS One 10 (9), e0138487, 2015
|Clinically relevant cytochrome P450 3A4 induction mechanisms and drug screening in three‐dimensional spheroid cultures of primary human hepatocytes|
DFG Hendriks, SU Vorrink, T Smutny, SC Sim, ┼ Nordling, S Ullah, ...
Clinical Pharmacology & Therapeutics 108 (4), 844-855, 2020
|Inter-individual differences in the susceptibility of primary human hepatocytes towards drug-induced cholestasis are compound and time dependent|
C Parmentier, DFG Hendriks, B Heyd, P Bachellier, ...
Toxicology letters 295, 187-194, 2018
|Mechanisms of chronic fialuridine hepatotoxicity as revealed in primary human hepatocyte spheroids|
DFG Hendriks, T Hurrell, J Riede, M van der Horst, S Tuovinen, ...
Toxicological Sciences 171 (2), 385-395, 2019
|In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed|
F Bonanini, D Kurek, S Previdi, A Nicolas, D Hendriks, S de Ruiter, ...
Angiogenesis 25 (4), 455-470, 2022