Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high
or even increase over time, a phenomenon named memory T-cell inflation. Besides, the …

Latent infection with cytomegalovirus (CMV) is thought to accelerate aging of the immune
system. With age, influenza vaccine responses are impaired. Although several studies …

The gut microbiota in early life, when critical immune maturation takes place, may influence
the immunogenicity of childhood vaccinations. Here we assess the association between …

Determining the optimal vaccination strategy for the protection of the elderly population against
pneumococcal disease remains a challenge. Older adults are, second to young infants, …

Night-shift workers experience disturbances of their circadian rhythm and sleep, which may
make them more susceptible to infectious diseases. Therefore, we studied whether night-…

Objectives Shift work may alter workers' leisure-time and occupational physical activity (PA)
levels, which might be one of the potential underlying mechanisms of the negative health …

CD8 + T cells play an important role in protection against viral infections. With age, changes
in the T-cell pool occur, leading to diminished responses against both new and recurring …

Klokwerk + study protocol: An observational study to the effects of night–shift work on body
weight and infection susceptibility and the mechanisms underlying these health effects | BMC …

The emergence of novel SARS-CoV-2 variants led to the recommendation of booster
vaccinations after Ad26.COV2.S priming. It was previously shown that heterologous booster …

Background Kidney transplant recipients (KTRs) have an impaired immune response after
vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Iron …