Upon cytomegalovirus (CMV) infection, large T-cell responses are elicited that remain high
or even increase over time, a phenomenon named memory T-cell inflation. Besides, the …

Latent infection with cytomegalovirus (CMV) is thought to accelerate aging of the immune
system. With age, influenza vaccine responses are impaired. Although several studies …

The gut microbiota in early life, when critical immune maturation takes place, may influence
the immunogenicity of childhood vaccinations. Here we assess the association between …

Objectives Shift work may alter workers' leisure-time and occupational physical activity (PA)
levels, which might be one of the potential underlying mechanisms of the negative health …

Night-shift workers experience disturbances of their circadian rhythm and sleep, which may
make them more susceptible to infectious diseases. Therefore, we studied whether night-…

CD8 + T cells play an important role in protection against viral infections. With age, changes
in the T-cell pool occur, leading to diminished responses against both new and recurring …

Klokwerk + study protocol: An observational study to the effects of night–shift work on body
weight and infection susceptibility and the mechanisms underlying these health effects | BMC …

T cells recognize pathogens by their highly specific T-cell receptor (TCR), which can bind
small fragments of an antigen presented on the Major Histocompatibility Complex (MHC). …

Aging leads to alterations in the immune system that result in ineffective responsiveness
against pathogens. Features of this process, collectively known as immunosenescence, …

Background Kidney transplant recipients (KTRs) have an impaired immune response after
vaccination against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Iron …