Doxil®, the first FDA-approved nano-drug (1995), is based on three unrelated principles: (i)
prolonged drug circulation time and avoidance of the RES due to the use of PEGylated nano-…

In the last decade a series of biophysical methods were introduced into the fields of biological
membranes. The studies on structure and dynamics of the membrane lipid matrix were …

Liposomes are now in the marketplace as cosmeticeuticals and, more important,
pharmaceuticals. Three major achievements of liposome application: steric stabilization, remote …

A new method is described for the preparation of homogeneously sized, single-lamellar
phospholipid vesicles. This method, which is based on differential high-speed ultra-…

340 DOV LICHTENBERG AND YECHEZKEL BARENHOLZ edited by Gregoriadis (1984),
and most recently in a special issue of Chemistry and Physics of Lipids entitled “Liposomes”(…

130 standing the structure and properties of phosphoglycerides and cholesterol, until recently
relatively little effort has been expended on sphingolipids. Sphingomyelins (N-acyl. spl~ …

The appearance of “membrane-active sterols” in biological membranes of eukaryocytes is
one of the major steps in membrane evolution. This is exemplified best by membrane-active …

In preclinical studies, a doxorubicin liposome formulation containing polyethylene-glycol (Doxil)
shows a long circulation time in plasma, enhanced accumulation in murine tumors, and …

Physical properties of the hydrocarbon region in lipid bilayers were studied in a series of
liposomes of lecithin and sphingomyelin containing different concentrations of dicetylphosphate…

First published in 1996, liposomes have become an important model in fundamental
biomembrane research, including biophysical, biochemical, and cell biological studies of …