DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

Methylation of CpG dinucleotides is a reversible modification of DNA that is highly prevalent
throughout mammalian genomes. Recent advances generated genomic DNA methylation …

The observation that imprinted genes exist in clusters suggests that mechanisms to control
imprinted expression act on the chromosomal domain rather than on individual genes (Reik …

DNA methylation is an epigenetic modification associated with transcriptional repression of
promoters and is essential for mammalian development. Establishment of DNA methylation …

Epigenetic factors determine responses to internal and external stimuli in eukaryotic organisms.
Whether and how environmental conditions feed back to the epigenetic landscape is …

To gain insight into the cellular readout of DNA methylation, we established a strategy for
systematically profiling the genome-wide distribution of chromatin-interacting factors. This …

Forward genetic screens with genome-wide CRISPR libraries are powerful tools for resolving
cellular circuits and signaling pathways. Applying this technology to organoids, however, …

Histone H3 trimethylation of lysine 9 (H3K9me3) and proteins of the heterochromatin protein
1 (HP1) family are hallmarks of heterochromatin, a state of compacted DNA essential for …

Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a
unipotent fate. This process was suggested to coincide with a global increase of repressive …

Covalent modification by methylation of cytosine residues represents an important epigenetic
hallmark. While sequence analysis after bisulphite conversion allows correlative analyses …