Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies. …

Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology. …

Therapies for patients with cancer have changed gradually over the past decade, moving
away from the administration of broadly acting cytotoxic drugs towards the use of more-specific …

RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic
screens in lower organisms and can greatly facilitate the identification of components of …

A large-scale RNA interference screen to discover genes involved in trastuzumab resistance
in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants …

Mammalian genetic approaches to study gene function have been hampered by the lack of
tools to generate stable loss-of-function phenotypes efficiently. We report here a new vector …

Breast cancer patients with the same stage of disease can have markedly different treatment
responses and overall outcome. The strongest predictors for metastases (for example, …

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and
drug responses. To resolve inconsistencies among the reported gene expression–based CRC …

The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that
their effects can be observed when they are introduced into non-malignant cells 1–4 . There …

Background A more accurate means of prognostication in breast cancer will improve the
selection of patients for adjuvant systemic therapy. Methods Using microarray analysis to …