Posttranslational modification of proteins by the small molecule ubiquitin is a key regulatory
event, and the enzymes catalyzing these modifications have been the focus of many studies. …

Senescence is a cellular response to a variety of stress signals that is characterized by a
stable withdrawal from the cell cycle and major changes in cell morphology and physiology. …

The serine/threonine protein phosphatase (PP2A) is a trimeric holoenzyme that plays an
integral role in the regulation of a number of major signaling pathways whose deregulation can …

RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic
screens in lower organisms and can greatly facilitate the identification of components of …

A large-scale RNA interference screen to discover genes involved in trastuzumab resistance
in breast cancer identified only PTEN as a modulator of drug sensitivity. Oncogenic mutants …

Mammalian genetic approaches to study gene function have been hampered by the lack of
tools to generate stable loss-of-function phenotypes efficiently. We report here a new vector …

The genomes of various tumour cells contain mutant oncogenes that act dominantly, in that
their effects can be observed when they are introduced into non-malignant cells 1–4 . There …

Protein modification by the conjugation of ubiquitin moieties—ubiquitination—plays a major
part in many biological processes, including cell cycle and apoptosis 1 . The enzymes that …

Breast cancer patients with the same stage of disease can have markedly different treatment
responses and overall outcome. The strongest predictors for metastases (for example, …

Colorectal cancer (CRC) is a frequently lethal disease with heterogeneous outcomes and
drug responses. To resolve inconsistencies among the reported gene expression–based CRC …