Methods of in vitro toxicology
G Eisenbrand, B Pool-Zobel, V Baker, M Balls… - Food and chemical …, 2002 - Elsevier
In vitro methods are common and widely used for screening and ranking chemicals, and have
also been taken into account sporadically for risk assessment purposes in the case of food …
also been taken into account sporadically for risk assessment purposes in the case of food …
Practical Aspects of the Validation of Toxicity Test Procedures: The Report and Recommendations of ECVAM Workshop 5,
M Balls, BJ Blaauboer, JH Fentem… - Alternatives to …, 1995 - journals.sagepub.com
This is the report of the fifth of a series of workshops organised by the European Centre for
the Validation of Alternative Methods (ECV AM). ECV AM's main goal, as defined in 1993 by …
the Validation of Alternative Methods (ECV AM). ECV AM's main goal, as defined in 1993 by …
Dose metric considerations in in vitro assays to improve quantitative in vitro–in vivo dose extrapolations
FA Groothuis, MB Heringa, B Nicol, JLM Hermens… - Toxicology, 2015 - Elsevier
Challenges to improve toxicological risk assessment to meet the demands of the EU
chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have …
chemical's legislation, REACH, and the EU 7th Amendment of the Cosmetics Directive have …
Metabolism: A Bottleneck in In Vitro Toxicological Test Development: The Report and Recommendations of ECVAM Workshop 54
S Coecke, H Ahr, BJ Blaauboer… - Alternatives to …, 2006 - journals.sagepub.com
This is the 54th report of a series of workshops organised by the European Centre for the
Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 …
Validation of Alternative Methods (ECVAM). The main objective of ECVAM, as defined in 1993 …
Structure elucidation of acid reaction products of indole-3-carbinol: detection in vivo and enzyme induction in vitro
CA De Kruif, JW Marsman, JC Venekamp… - Chemico-biological …, 1991 - Elsevier
The potency of indole-3-carbinol (I3C) to form condensation products under acidic aqueous
conditions was studied. After identifying a known dimer, 3,3′-diindolylmethane (DIM), we …
conditions was studied. After identifying a known dimer, 3,3′-diindolylmethane (DIM), we …
Mechanism-based testing strategy using in vitro approaches for identification of thyroid hormone disrupting chemicals
ATJ Murk, E Rijntjes, BJ Blaauboer, R Clewell… - Toxicology in vitro, 2013 - Elsevier
The thyroid hormone (TH) system is involved in several important physiological processes,
including regulation of energy metabolism, growth and differentiation, development and …
including regulation of energy metabolism, growth and differentiation, development and …
[HTML][HTML] Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress
High content omic techniques in combination with stable human in vitro cell culture systems
have the potential to improve on current pre-clinical safety regimes by providing detailed …
have the potential to improve on current pre-clinical safety regimes by providing detailed …
Biokinetic Modeling and in Vitro–in Vivo Extrapolations
BJ Blaauboer - Journal of Toxicology and Environmental Health …, 2010 - Taylor & Francis
The introduction of in vitro methodologies in the toxicological risk assessment process requires
a number of prerequisites regarding both the toxicodynamics and the biokinetics of the …
a number of prerequisites regarding both the toxicodynamics and the biokinetics of the …
Solid Phase Microextraction as a Tool To Determine Membrane/Water Partition Coefficients and Bioavailable Concentrations in in Vitro Systems
WHJ Vaes, E Urrestarazu Ramos… - Chemical research in …, 1997 - ACS Publications
Solid phase microextraction (SPME) is an extraction technique that uses a polymer-coated
fiber as the extraction device. After extraction, the compound of interest can be desorbed from …
fiber as the extraction device. After extraction, the compound of interest can be desorbed from …
The Use of In Vitro Toxicity Data and Physiologically Based Kinetic Modeling to Predict Dose-Response Curves for In Vivo Developmental Toxicity of Glycol Ethers in …
J Louisse, E de Jong, JJM van de Sandt… - Toxicological …, 2010 - academic.oup.com
At present, regulatory assessment of systemic toxicity is almost solely carried out using
animal models. The European Commission’s REACH legislation stimulates the use of animal-…
animal models. The European Commission’s REACH legislation stimulates the use of animal-…
