A molecular basis for bidirectional communication between the immune and neuroendocrine systems.
JE Blalock - Physiological reviews, 1989 - journals.physiology.org
2 J. EDWIN BLALOCK Vdume 69 systems, which we term neuroimmunoendocrinology(73).
Although this field was, in part, defined in 1977 (13), its origins are much earlier and may …
Although this field was, in part, defined in 1977 (13), its origins are much earlier and may …
The syntax of immune-neuroendocrine communication
JE Blalock - Immunology today, 1994 - cell.com
There is nou, overwhelming evtdence that cytokines, peptide hormones and neurotransmitters,
as well as their receptors, are endogenous to the brain, endocrine and immune systems. …
as well as their receptors, are endogenous to the brain, endocrine and immune systems. …
The immune system as the sixth sense
JE Blalock - Journal of internal medicine, 2005 - Wiley Online Library
One of the truly remarkable discoveries in modern biology is the finding that the nervous
system and immune system use a common chemical language for intra‐ and inter‐system …
system and immune system use a common chemical language for intra‐ and inter‐system …
Human leukocyte interferon: structural and biological relatedness to adrenocorticotropic hormone and endorphins.
JE Blalock, EM Smith - … of the National Academy of Sciences, 1980 - National Acad Sciences
Anti-alpha-corticotropin [anti-ACTH alpha (1-13)](also alpha-melanotropin) and anti-gamma-endorphin
antisera neutralized human leukocyte interferon activity but not fibroblast …
antisera neutralized human leukocyte interferon activity but not fibroblast …
A novel peptide CXCR ligand derived from extracellular matrix degradation during airway inflammation
NM Weathington, AH Van Houwelingen… - Nature medicine, 2006 - nature.com
We describe the tripeptide neutrophil chemoattractant N-acetyl Pro-Gly-Pro (PGP), derived
from the breakdown of extracellular matrix (ECM), which shares sequence and structural …
from the breakdown of extracellular matrix (ECM), which shares sequence and structural …
[HTML][HTML] Activated PMN exosomes: pathogenic entities causing matrix destruction and disease in the lung
KR Genschmer, DW Russell, C Lal, T Szul, PE Bratcher… - Cell, 2019 - cell.com
Here, we describe a novel pathogenic entity, the activated PMN (polymorphonuclear leukocyte,
ie, neutrophil)-derived exosome. These CD63 + /CD66b + nanovesicles acquire surface-…
ie, neutrophil)-derived exosome. These CD63 + /CD66b + nanovesicles acquire surface-…
Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.
EM Smith, JE Blalock - … of the National Academy of Sciences, 1981 - National Acad Sciences
Human leukocyte interferon (hIFN-alpha) preparations contain immunologically and
biologically recognizable endorphin and corticotropin-like (ACTH-like) activities. The ACTH …
biologically recognizable endorphin and corticotropin-like (ACTH-like) activities. The ACTH …
Conceptual development of the immune system as a sixth sense
JE Blalock, EM Smith - Brain, behavior, and immunity, 2007 - Elsevier
Understanding how and why the immune and nervous systems communicate in a bidirectional
pathway has been fundamental to the development of the psychoneuroimmunology (PNI) …
pathway has been fundamental to the development of the psychoneuroimmunology (PNI) …
A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation
RJ Snelgrove, PL Jackson, MT Hardison, BD Noerager… - Science, 2010 - science.org
Leukotriene A 4 hydrolase (LTA 4 H) is a proinflammatory enzyme that generates the
inflammatory mediator leukotriene B 4 (LTB 4 ). LTA 4 H also possesses aminopeptidase activity …
inflammatory mediator leukotriene B 4 (LTB 4 ). LTA 4 H also possesses aminopeptidase activity …
[PDF][PDF] Peptide hormones shared by the neuroendocrine and immunologic systems
JE Blalock, D Harbour-McMenamin, EM Smith - 1985 - m.pnei-it.com
While numerous studies have demonstrated that the neuroendocrine system can control
immune functions, it is only now becoming apparent that the control is reciprocal in that the …
immune functions, it is only now becoming apparent that the control is reciprocal in that the …
