The mineralogy of terrestrial planets evolves as a consequence of a range of physical, chemical,
and biological processes. In pre-stellar molecular clouds, widely dispersed microscopic …

The tectonic evolution of Archaean granite-greenstone terranes remains controversial. Here
this subject is reviewed and illustrated with new data from the Slave craton. These data …

Advances in gene transfer approaches are enabling the possibility of applying therapeutic
antibodies using DNA. In particular gene transfer in combination with electroporation is …

Background Systemic relapses remain a major problem in locally advanced rectal cancer.
Using short-course radiotherapy followed by chemotherapy and delayed surgery, the Rectal …

CD38, a type II transmembrane glycoprotein highly expressed in hematological
malignancies including multiple myeloma (MM), represents a promising target for mAb-based …

Antibodies play a central role in immunity by forming an interface with the innate immune
system and, typically, mediate proinflammatory activity. We describe a novel posttranslational …

Neutralizing antibodies are thought to be crucial for HIV vaccine protection, but studies in
animal models suggest that high antibody concentrations are required 1 . This is a major …

Daratumumab (DARA) is a human CD38-specific IgG1 antibody that is in clinical development
for the treatment of multiple myeloma (MM). The potential for IgG1 antibodies to induce …

A Geologic Time Scale (GTS2004) is presented that integrates currently available stratigraphic
and geochronologic information. Key features of the new scale are outlined, how it was …

Precambrian supercontinents Nuna-Columbia (1.7 to 1.3 billion years ago) and Rodinia (1.1
to 0.7 billion years ago) have been proposed. However, the arrangements of crustal blocks …