In the early 1960s, shortly after the introduction of oral contraceptives, the first case reports
appeared describing venous thrombosis and pulmonary emboli in women using this method …

… von dem Borne PA, Meijers JC, Bouma BN. Feedback activation of factor XI by thrombin
in plasma results in additional formation of thrombin that protects fibrin clots from fibrinolysis. …

Recently, a new inhibitor of fibrinolysis was described, which downregulated fibrinolysis
after it was activated by thrombin, and was therefore named TAFI (thrombin-activatable …

Background Factor XI, a component of the intrinsic pathway of coagulation, contributes to
the generation of thrombin, which is involved in both the formation of fibrin and protection …

… Derksen RHWM, Bouma BN, Kater L The striking association between lupus anticoagulant
and fetal loss in systemic lupus erythematosus. Arthritis Rheum 29:695, 1986 5. Lechner K, …

MATERIALS AND METHODS All chemicals obtained from commercial sources were the best
grade available. Human Factor XII (80 clotting units/mg) was purified on DEAE-Sephadex A…

… Mosnier LO, von dem Borne PAKr, Meijers JCM, Bouma BN. Plasma TAFI levels influence the
… de Swart CAM, Nijmeyer B, Andersson LO, Holmer E, Sixma JJ, Bouma BN. Elimination of …

… van 't Veer C, Hackeng TM, Delahaye C, Sixma JJ, Bouma BN: Activated factor X and
thrombin formation triggered by tissue factor on endothelial cell matrix in a flow model: Effect of …

When blood is exposed to negatively charged surface materials such as glass, an enzymatic
cascade known as the contact system becomes activated. This cascade is initiated by …

The use of oral contraceptives (OC) causes disturbances of the procoagulant, anticoagulant
and fibrinolytic pathways of blood coagulation which may contribute to the increased risk of …