Het vak fysiologie verschaft belangrijke basiskennis aan uiteenlopende medische
beroepsgroepen. Omdat het vak zich razendsnel ontwikkelt, is het leerboek Medische fysiologie …

In isolated preparations of the rabbit sinus node, we have investigated the fine structure of
the tissue at many sites which had been electrophysiologically identified by means of …

AUTHORS' SYNOPSIS Carotid sinus nerve stimulation (CSNS) was applied in seven angina
pectoris patients for periods of 1–2 min, using a modified Angistat (Medtronic) stimulator at …

Loss of parkin function is responsible for the majority of autosomal recessive parkinsonism.
Here, we show that parkin is not only a stress-protective, but also a stress-inducible protein. …

In isolated right atria of the rabbit heart, we studied the activation pattern within the sinus
node, using the microelectrode technique. After the electrophysiological experiments, the …

Loss-of-function mutations in the parkin gene (PARK2) and PINK1 gene (PARK6) are
associated with autosomal recessive parkinsonism. PINK1 deficiency was recently linked to …

Mutations in the parkin gene are a major cause of autosomal recessive Parkinson's disease.
Here we show that the E3 ubiquitin ligase parkin activates signaling through the IκB kinase (…

The shortening of the RR interval in response to voluntary and electrically induced isometric
muscle contractions of short duration was investigated in 15 volunteers. In some of those …

Objective: The sinoatrial (SA) node consists of a relatively small number of poorly coupled
cells. It is not well understood how these pacemaker cells drive the surrounding atrium and at …

Background—In the sinoatrial node (SAN) the course of the action potential gradually
changes from the primary pacemaker region toward the atrium. It is not known whether this …