This report summarizes the documented cases of homozygous protein C deficiency in the
United States and Europe. Procedures for diagnosing and treating this disorder (both initially …

To analyze the clinical manifestations of protein S deficiency, we evaluated 136 members of
12 families with the disorder. Seventy-one persons were found to be heterozygous for …

Protein C is the zymogen of a vitamin K–dependent serine protease involved in blood
coagulation. In the absence of protein C the inactivation of activated factors V and VIIIC is impaired…

The report by one of us (VH) of a patient who developed skin necrosis not only during the
initial phase of oral anticoagulant therapy, but also at the onset of cholestatic vitamin K …

A rabbit antibody against human protein C was used for the quantitative estimation of protein
C in plasma. In healthy individuals protein C antigen ranged from 0.65-1.45 U/ml. Plasma …

OBJECTIVE: The purpose of this study was to determine if fear of an increased risk of
attempted suicide in placebo groups participating in placebo-controlled studies is an argument …

Advanced therapy medicinal products (ATMPs) hold promise as treatments for previously
untreatable and high-burden diseases. Expectations are high and active company pipelines …

Protein C is a vitamin K dependent protein involved in blood coagulation. A congenital
deficiency in protein C antigen - which inherits as an autosomal dominant disorder - has been …

Protein S, a vitamin K-dependent coagulation factor, is involved in the regulation of the
anticoagulant activity of activated protein C. Using an immunoradiometric assay for total protein S …

Objective: To investigate differences in attitudes, knowledge and actual use of economic
evaluations in different groups of decision-makers, and to compare the results from the …