cAMP antagonizes p21ras‐directed activation of extracellular signal‐regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.
BM Burgering, GJ Pronk, PC van Weeren… - The EMBO …, 1993 - embopress.org
In fibroblasts, stimulation of receptor tyrosine kinases results in the activation of the extracellular
signal‐regulated kinase 2 (ERK2). The major signalling pathway employed by these …
signal‐regulated kinase 2 (ERK2). The major signalling pathway employed by these …
Activation of p70/p85 S6 kinase by a pathway independent of p21fi ras
XF Ming, BMT Burgering, S Wennstrom… - Nature, 1994 - nature.com
THE enzymes p70 s6k and p85 s6k are two isoforms of the same kinase 1,2 and are important
in mitogenesis 2–4 . Both isoforms are activated by a complex phosphorylation event5 …
in mitogenesis 2–4 . Both isoforms are activated by a complex phosphorylation event5 …
Direct control of the Forkhead transcription factor AFX by protein kinase B
GJPL Kops, ND Ruiter, AMM De Vries-Smits… - Nature, 1999 - nature.com
The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B ( 1 , 2 ) regulates
certain insulin-responsive genes 3 , 4 , but the transcription factors regulated by protein kinase …
certain insulin-responsive genes 3 , 4 , but the transcription factors regulated by protein kinase …
The Role of Small GTPases in Signal Transduction
Small GTPases are proteins of about 21kD that cycle between an active GTP-bound state
and an inactive GDP-bound state. They can be considered as molecular switches in a variety …
and an inactive GDP-bound state. They can be considered as molecular switches in a variety …
Mdm2 induces mono-ubiquitination of FOXO4
AB Brenkman, PLJ de Keizer, NJF van den Broek… - PloS one, 2008 - journals.plos.org
Background The Forkhead box O (FOXO) class of transcription factors are involved in the
regulation of several cellular responses including cell cycle progression and apoptosis. …
regulation of several cellular responses including cell cycle progression and apoptosis. …
c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to cAMP inhibition in T lymphocytes
The molecular mechanism underlying the cAMP inhibition of nuclear activation events in T
lymphocytes is unknown. Recently, the activation of fibroblasts and muscle cells are shown to …
lymphocytes is unknown. Recently, the activation of fibroblasts and muscle cells are shown to …
The role of glycogen synthase kinase 3β in insulin-stimulated glucose metabolism
SA Summers, AW Kao, AD Kohn, GS Backus… - Journal of Biological …, 1999 - ASBMB
To characterize the contribution of glycogen synthase kinase 3β (GSK3β) inactivation to
insulin-stimulated glucose metabolism, wild-type (WT-GSK), catalytically inactive (KM-GSK), and …
insulin-stimulated glucose metabolism, wild-type (WT-GSK), catalytically inactive (KM-GSK), and …
High affinity binding of inositol phosphates and phosphoinositides to the pleckstrin homology domain of RAC/protein kinase B and their influence on kinase activity
M Frech, M Andjelkovic, E Ingley, KK Reddy… - Journal of Biological …, 1997 - ASBMB
The influence of inositol phosphates and phosphoinositides on the α isoform of the RAC-protein
kinase B (RAC/PKB) was studied using purified wild type and mutant kinase …
kinase B (RAC/PKB) was studied using purified wild type and mutant kinase …
Inhibition of glycogen-synthase kinase 3 stimulates glycogen synthase and glucose transport by distinct mechanisms in 3T3-L1 adipocytes
SJ Oreña, AJ Torchia, RS Garofalo - Journal of Biological Chemistry, 2000 - ASBMB
The role of glycogen-synthase kinase 3 (GSK3) in insulin-stimulated glucose transport and
glycogen synthase activation was investigated in 3T3-L1 adipocytes. GSK3 protein was …
glycogen synthase activation was investigated in 3T3-L1 adipocytes. GSK3 protein was …
Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes: a putative …
A Tirosh, R Potashnik, N Bashan, A Rudich - Journal of Biological …, 1999 - ASBMB
In a recent study we have demonstrated that 3T3-L1 adipocytes exposed to low micromolar
H 2 O 2 concentrations display impaired insulin stimulated GLUT4 translocation from internal …
H 2 O 2 concentrations display impaired insulin stimulated GLUT4 translocation from internal …