In fibroblasts, stimulation of receptor tyrosine kinases results in the activation of the extracellular
signal‐regulated kinase 2 (ERK2). The major signalling pathway employed by these …

THE enzymes p70 s6k and p85 s6k are two isoforms of the same kinase 1,2 and are important
in mitogenesis 2–4 . Both isoforms are activated by a complex phosphorylation event5 …

The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B ( 1 , 2 ) regulates
certain insulin-responsive genes 3 , 4 , but the transcription factors regulated by protein kinase …

Small GTPases are proteins of about 21kD that cycle between an active GTP-bound state
and an inactive GDP-bound state. They can be considered as molecular switches in a variety …

Background The Forkhead box O (FOXO) class of transcription factors are involved in the
regulation of several cellular responses including cell cycle progression and apoptosis. …

The molecular mechanism underlying the cAMP inhibition of nuclear activation events in T
lymphocytes is unknown. Recently, the activation of fibroblasts and muscle cells are shown to …

To characterize the contribution of glycogen synthase kinase 3β (GSK3β) inactivation to
insulin-stimulated glucose metabolism, wild-type (WT-GSK), catalytically inactive (KM-GSK), and …

The influence of inositol phosphates and phosphoinositides on the α isoform of the RAC-protein
kinase B (RAC/PKB) was studied using purified wild type and mutant kinase …

The role of glycogen-synthase kinase 3 (GSK3) in insulin-stimulated glucose transport and
glycogen synthase activation was investigated in 3T3-L1 adipocytes. GSK3 protein was …

In a recent study we have demonstrated that 3T3-L1 adipocytes exposed to low micromolar
H 2 O 2 concentrations display impaired insulin stimulated GLUT4 translocation from internal …