Prader-Willi syndrome is a genetic disorder occurring in 1 in 10,000–16,000 live-born infants.
In the general population, approximately 60 people in every 1,000,000 are affected. The …

Background Pituitary tumours are common and easily treated by surgery or medical treatment
in most cases. However, a small subset of pituitary tumours does not respond to standard …

Context: Dopamine agonists are the treatment of choice for prolactinomas and symptomatic
idiopathic hyperprolactinemia. However, the optimal treatment strategy and treatment …

We examined the effect of GH supplementation on the psychological capacity and sense of
well-being in 36 patients with adult-onset GH deficiency (GHD). Recombinant human GH …

PD-1 blockade unleashes CD8 T cells 1 , including those specific for mutation-associated
neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell …

Thirty-six patients with adult-onset GH deficiency (GHD) were examined before and after 9
months of treatment with recombinant GH. The study was conducted as a double blind, …

Abstract Concepts of v-fold cross validation and repeated learning-testing methods have
been introduced here. In many problems, these methods are computationally much less …

Objective To describe clinical and pathological characteristics and treatment outcomes in a
large cohort of aggressive pituitary tumours (APT)/pituitary carcinomas (PC). Design …

Context: Patients with treated adrenal insufficiency (AI) have increased morbidity and
mortality rate. Our goal was to improve outcome by developing a once-daily (OD) oral …

Context: Patients with hypopituitarism have an increased standardized mortality rate. The
basis for this has not been fully clarified. Objective: To investigate in detail the cause of death …