Affective and non-affective psychoses are severe and frequent psychiatric disorders.
Amongst others, they not only have a profound impact on affected individuals through their …

Schizophrenia has a heritability of 60–80% 1 , much of which is attributable to common risk
alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with …

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …

Polygenic risk scores have shown great promise in predicting complex disease risk and will
become more accurate as training sample sizes increase. The standard approach for …

Background Imaging studies of patients with schizophrenia have demonstrated that brain
abnormalities are largely confined to decreases in gray matter volume and enlargement of the …

Copy number variants (CNVs) have been strongly implicated in the genetic etiology of
schizophrenia (SCZ). However, genome-wide investigation of the contribution of CNV to risk has …

Background The profile of cortical neuroanatomical abnormalities in schizophrenia is not
fully understood, despite hundreds of published structural brain imaging studies. This study …

Although structural brain alterations in schizophrenia have been demonstrated extensively,
their quantitative distribution has not been studied over the last 14 years despite advances in …

Regulatory and coding variants are known to be enriched with associations identified by
genome-wide association studies (GWASs) of complex disease, but their contributions to trait …

The regional distribution of white matter (WM) abnormalities in schizophrenia remains poorly
understood, and reported disease effects on the brain vary widely between studies. In an …