Some of the most important structures in the immune system are the receptors for the Fc
domain of antibodies. These provide an essential feedback between the humoral and the cell-…

The complex family of human IgG Fc receptors show a wide cellular distribution and a strong
functional heterogeneity. To date, eight different genes that are transcribed into at least 12 …

The family of receptors for IgG (FcγR) plays an essential role in antibody-mediated effector
functions of the immune system. However, the specific contribution of each of the FcγR …

XERODERM A pigmentosum patients with a defect in the nucleotide-excision repair gene
XPA are characterized by, for example, a > 1,000-fold higher risk of developing sunlight-…

Previously, we have demonstrated that phagocytosis of IgG1-coated particles by macrophages
in vitro is impaired by deletion of FcγRIII in mice, suggesting that IgG1 may interact …

… Warmerdam PAM, van de Winkel JGJ, Gosselin EJ, Capel PJA: Molecular basis for a
polymorphism of human Fcy receptor I1 (CD32). J Exp Med 172:1!3-25, 1990 Parren PWHI, …

It has recently been described that monoclonal antibody OKT 3, that reacts with the T3
determinant on all peripheral T lymphocytes in man, is also mitogenic for T cells 1,2 . We have …

FcR γ chain has previously been shown to interact with the TCR-CD3 complex, the IgE Fc
receptor I (Fc∊RI), and the class I and IIIA IgG receptors (FcγRI and FcγRIIIa). Here, we …

… Warmerdam PAM, van de Winkel JGJ, Gosselin EJ, Capel PJA. Molecular basis for a …
van de Winkel JGJ, Capel PJA. Human IgG Fe receptor heterogeneity: molecular aspects …

Islet amyloid polypeptide (“amylin”) is the major protein component of amyloid deposits in
pancreatic islets of type 2 (non‐insulin‐dependent) diabetic patients. Islet amyloid polypeptide …