We performed RNA-seq and high-resolution mass spectrometry on 128 blood samples from
COVID-19-positive and COVID-19-negative patients with diverse disease severities and …

Mass spectrometry has played an integral role in the identification of proteins and their post-translational
modifications (PTM). However, analysis of some PTMs, such as phosphorylation…

Clinical proteomics has yielded some early positive results—the identification of potential
disease biomarkers—indicating the promise for this analytical approach to improve the current …

Sparked by the article from Lescuyer and colleagues in a recent issue, we aim here to further
encourage interest in and discussion of clinically relevant biomarker research. We express …

Peptide sequence analysis using a combination of gas-phase ion/ion chemistry and tandem
mass spectrometry (MS/MS) is demonstrated. Singly charged anthracene anions transfer an …

Selected reaction monitoring on a triple quadrupole mass spectrometer is currently experiencing
a renaissance within the proteomics community for its, as yet, unparalleled ability to …

Lignin is a heterogeneous aromatic biopolymer that accounts for nearly 30% of the organic
carbon on Earth 1 and is one of the few renewable sources of aromatic chemicals 2 . As the …

Calorie restriction (CR) extends life span in diverse species. Mitochondria play a key role in
CR adaptation; however, the molecular details remain elusive. We developed and applied a …

We present a strategy for the analysis of the yeast phosphoproteome that uses endo-Lys C
as the proteolytic enzyme, immobilized metal affinity chromatography for phosphopeptide …

We describe the comprehensive analysis of the yeast proteome in just over one hour of
optimized analysis. We achieve this expedited proteome characterization with improved sample …