A drawback of the current mRNA-lipid nanoparticle (LNP) COVID-19 vaccines is that they
have to be stored at (ultra)low temperatures. Understanding the root cause of the instability of …

As more recombinant human proteins become available on the market, the incidence of
immunogenicity problems is rising. The antibodies formed against a therapeutic protein can …

In the first part of this article, chemical and physical stability of aqueous liposome dispersions
have been addressed. Chemical stability of phospholipids has been considered in two …

Formaldehyde is a well known cross-linking agent that can inactivate, stabilize, or immobilize
proteins. The purpose of this study was to map the chemical modifications occurring on …

Therapeutic protein products provide unique and effective treatments for numerous human
diseases and medical conditions. In many cases, these treatments are used chronically to …

As mRNA vaccines became the frontrunners in late-stage clinical trials to fight the COVID-19
pandemic, challenges surrounding their formulation and stability became readily apparent. …

The present paper reports on the results of a systematic study on liposome variables
potentially affecting lymphatic disposition and biodistribution of liposomes after sc injection. …

Purpose. The aim of this study was to gain insight into the relation between the physical
characteristics of particles formed by a plasmid and a synthetic cationic polymer (poly(2-…

Liposomes have matured as a delivery system for therapeutic agents. It has taken two
decades to develop the liposome carrier concept to a pharmaceutical product level, but …

Nanotechnology is a rapidly expanding multidisciplinary field in which highly sophisticated
nanoscale devices are constructed from atoms, molecules or (macro)molecular assemblies. …